Differential regulation of forebrain glutamic acid decarboxylase mRNA expression by aging and stress

Brain Research

Volumn 912, Issue 1, 2001, Pages 60-66

  Herman, James P ^a,b   Larson, Benjamin R ^b  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Aging; Bed nucleus of the stria terminalis; Chronic stress; GABA; Preoptic area

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; ISOENZYME; MESSENGER RNA;

AGING; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; FOREBRAIN; MALE; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRESS; STRIA TERMINALIS;

AGING; ANIMALS; GLUTAMATE DECARBOXYLASE; HIPPOCAMPUS; MALE; NEURAL PATHWAYS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PREOPTIC AREA; PROSENCEPHALON; RATS; RATS, INBRED F344; RNA, MESSENGER; SEPTAL NUCLEI; STRESS;

EID: 0035979851     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02641-5     Document Type: Article

References (33)

1. Effects of age and gender on pituitary-adrenocortical responsiveness in humans
2. Region-specific regulation of glutamic acid decarboxylase (GAD) mRNA expression in central stress circuits
3. Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age
4. Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis
5. Aging and photoperiod regulate glutamic acid decarboxylase(67) messenger RNA expression
6. Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms
7. 67 mRNAs suggest that the two glutamate decarboxylases play distinctive functional roles
8. Neuroendocrine correlates of the aging brain in humans
9. Antiandrogen microimplants into the rostral medial preoptic area decrease gamma-aminobutyric acidergic neuronal activity and increase luteinizing hormone secretion in the intact male rat
10. The Brown Norway rat as a model of male reproductive aging: Evidence for both primary and secondary testicular failure
11. Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats
12. Ventral subiculum coordinates situation-specific neuroendocrine and behavioral stress responses
13. Hypothalamo-pituitary-adrenocortical dysregulation in aging F344/Brown-Norway F1 hybrid rats
14. Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis
15. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats
16. Changes in brain corticotropin-releasing factor messenger RNA expression in aged Fischer 344 rats
17. Increased glutamic acid decarboxylase (GAD) mRNA and GAD activity in cerebellar Purkinje cells following lesion-induced increases in cell firing
18. Regulatory properties of brain glutamate decarboxylase (GAD): The apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain
19. The role of the hippocampal mineralocorticoid and glucocorticoid receptors in the hypothalamo-pituitary-adrenal axis of the aged Fischer rat
20. Anatomical interactions between the central amygdaloid nucleus and the hypothalamic paraventricular nucleus of the rat: A dual tract-tracing analysis
21. Age-related changes in the dog hypothalamic-pituitary-adrenocortical system: Neuroendocrine activity and corticosteroid receptors
22. Do glucocorticoid concentrations rise with age in the rat?
23. The adrenocortical stress response in the aged rat: Impairment of recovery from stress
24. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis
25. Inhibition of glucocorticoid secretion by the hippocampal formation in the primate
26. Analysis of recurrent inhibitory circuit in rat thalamus: Neurophysiology of the thalamic reticular nucleus
27. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study
28. Rat central amygdaloid nucleus projections to the bed nucleus of the stria terminalis
29. Age-related reduction in pituitary corticotropin-releasing hormone receptors in two rat strains
30. Adrenocortical hyporesponsiveness and glucocorticoid feedback resistance in old male brown Norway rats
31. Spontaneous and glucocorticoid-inhibited adrenocorticotropic hormone and cortisol secretion are similar in healthy young and old men
32. Cross-sectional and longitudinal analysis of age-associated changes in body composition of male Brown Norway rats: Association of serum leptin levels with peripheral adiposity