Filter extrusion of liposomes using different devices: Comparison of liposome size, encapsulation efficiency, and process characteristics

International Journal of Pharmaceutics

Volumn 223, Issue 1-2, 2001, Pages 55-68

  Berger, N ^a,b   Sachse, A ^a   Bender, J ^b   Schubert, R ^b   Brandl, M ^b,c  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Extrusion; Filter; Liposome; Particle size; Phosphatidylcholine; Vesicle

Indexed keywords

CALCEIN; LIPOSOME; PHOSPHATIDYLCHOLINE;

ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; DISPERSION; ENCAPSULATION; FILTRATION; FLOW RATE; LIPID MEMBRANE; PARTICLE SIZE; PRIORITY JOURNAL; TECHNIQUE; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0035979414     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00721-9     Document Type: Article

References (24)

1. Evaluation of a new extrusion device for the production of stable oligolamellar liposomes in a litre scale
2. Effects of solute concentration of the entrapment of solutes in phospholipid vesicles prepared by freeze-thaw extrusion
3. Comparison of particle size encapsulation parameters of three liposomal preparations
4. 31P NMR
5. The effect of aging on the physical stability of liposome dispersions
6. Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
7. Reduction of liposome size and preparation of unilamellar vesicles by extrusion techniques
8. Characterization of liposomes. The influence of extrusion of multilamellar vesicles through polycarbonate membranes on particle size, particle size distribution and number of bilayers
9. Size analysis and stability study of lipid vesicles by high-performance gel exclusion chromatography, turbidity and dynamic light scattering
10. Small volume extrusion apparatus for preparation of large unilamellar vesicles
11. Vesicles of variable sizes produced by a rapid extrusion procedure
12. Generation of large unilamellar vesicles from long-chain saturated phosphatidylcholines by extrusion technique
13. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes
14. Large-scale production of liposomes by continuous high pressure extrusion
15. Large-scale production of liposomes of defined size by a new continuous high pressure extrusion device
16. Generation of contrast-carrying liposomes of defined size with a new continuous high pressure extrusion method
17. Surface modification of continuously extruded contrast-carrying liposomes: Effect on their physical properties
18. Loading of preformed liposomes with high trapping efficiency by detergent-induced formation of transient membrane holes
19. Preparation of unilamellar liposomes of intermediate size (0.1-0.2 μm) by a combination of reverse phase evaporation and extrusion through polycarbonate membranes
20. The design of liposomal paramagnetic MR agents: Effect of vesicle size upon the relaxivity of surface-incorporated lipophilic chelates
21. Fast-protein liquid chromatography system as a tool for liposome preparation by the extrusion procedure