Surface modification of continuously extruded contrast-carrying liposomes: Effect on their physical properties

International Journal of Pharmaceutics

Volumn 132, Issue 1-2, 1996, Pages 9-21

  Schneider, T ^a,b   Sachse, A ^a   Leike, J ^a   Roßling G ^a   Schmidtgen, M ^b   Drechsler, M ^b   Brandl, M ^b  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Amphipathic polymer; CHOLHS PEG; Continuous extrusion; Contrast agent; DSPE PEG; Liposome; Surface modification

Indexed keywords

CHOLESTEROL HYDROGEN SUCCINATE; CONTRAST MEDIUM; DISTEAROYLPHOSPHATIDYLCHOLINE; GADOLINIUM PENTETATE; IOPROMIDE; LIPOSOME; MACROGOL; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPID; POLYMER;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG STABILITY; DRUG STORAGE; ENCAPSULATION; GEL FILTRATION; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE PROPERTY;

EID: 0029996614     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04247-4     Document Type: Article

References (27)

1. Allen, T.M., Interactions of liposomes and other drug carriers with the mononuclear phagocyte system. In Gregoriadis, G. (Ed.), Liposomes as Drug Carriers, John Wiley and Sons Ltd., Chichester, New York, Brisbane, Toronto, Singapore, 1988, pp. 37-50.
2. Allen, T.M., Stealth-liposomes: five years on. J. Liposome Res., 2 (1992) 289-305.
3. Allen, T.M., The use of glycolipids and hydrophilic polymers in avoiding rapid uptake of liposomes by the mononuclear phagocyte system. Adv. Drug Deliv. Rev., 13 (1994) 285-309.
4. Allen, T.M. and Chonn, A., Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett., 223 (1987) 42-46.
5. Blume, G. and Cevc, G., Liposomes for the sustained drug release in vivo. Biochim. Biophys. Acta, 1029 (1990) 91-97.
6. Chonn, A. and Cullis, P.R., Ganglioside GM1 and hydrophilic polymers increase liposome circulation times by inhibiting the association of blood proteins. J. Liposome Res., 2 (1992) 397-410.
7. Delgado, C., Patel, J.N., Francis, G.E. and Fisher, D., Coupling of poly(ethylene glycol) to albumin under very mild conditions by activation with tresyl chloride: Characterization of the conjugate by partitioning in aqueous two-phase systems. Biotech. Appl. Biochem., 12 (1990) 119-128.
8. Havron, A., Seltzer, S.E., Davis, M.A. and Shulkin, P., Radio-paque liposomes: a promising new contrast material for computed tomography of the spleen. Radiology, 140 (1981) 507-511.
9. Henze, A., Freise, J., Magerstedt, P. and Majewski, A., Radio-opaque liposomes for the improved visualisation of focal liver disease by computerized tomography. Comp. Med. Imag. Graph., 13 (1989) 455-462.
10. Kabalka, G., Buonocore, E., Hubner, K., Moss, T., Norley, N. and Huang, L., Gadolinium-labeled liposomes: targeted MR contrast agents for the liver and spleen Radiology, 163 (1987) 255-258.
11. Kaufmann, L., Deconinck, F., Price, D.C., Guesry, P., Wilson, C.J., Hruska, B., Swann, S.J., Camp, D.C., Voegele, A.L., Friesen, R.D. and Nelson, J.A., An automated fluorescent excitation analysis system for medical applications. Invest. Radiol., 11 (1976) 210-215.
12. Klibanov, A., Maruyama, K., Torchilin, V.P. and Huang, L., Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett., 268 (1990) 235-237.
13. Klibanov, A.L., Maruyama, K., Beckerleg, A.M., Torchilin, V.P. and Huang, L., Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim. Biophys. Acta. 1062 (1991) 142-148.
14. Lasic, D.D., Martin, F.J., Gabizon, A., Huang, S.K. and Papahadjopoulos, D., Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times, Biochim. Biophys. Acta. 1070 (1991) 187-192.
15. Needham, D., Hristova, K., McIntosh, T.J., Dewhirst, M., Wu, N. and Lasic, D.D., Polymer-grafted liposomes: physical basis for the 'stealth' property. J. Liposome Res., 2 (1992) 411-430.
16. Papahadjopoulos, D., Allen, T.M., Gabizon, A., Mayhew, E., Matthay, K., Huang, S.K., Lee, K.-D., Woodle, M.C., Lasic, D.D., Redemann, C. and Martin, F.J., Sterically stabilized liposomes: improvement in pharmacokinetics and antitumor therapeutic efficiency. Proc. Natl. Acad. Sci. USA, 88 (1991) 11460-11464.
17. Ryan, P.J., Davis, M.A. and Melchior, D.I., The preparation and characterisation of liposomes containing x-ray contrast agents. Biochim. Biophys. Acta, 756 (1983) 106-110.
18. Sachse, A., Leike, J.U., Rößling, G.L., Wagner, S.E. and Krause, W., Preparation and evaluation of lyophilized iopromide-carrying liposomes for liver tumor detection. Invest. Radiol., 28 (1993) 838-844.
19. Schneider, T., Sachse, A., Rößling, G. and Brandl, M., Large-scale production of liposomes of defined size by a new continuous high pressure extrusion device. Drug Dev. Ind. Pharm., 20 (1994) 2787-2807.
20. Schneider, T., Sachse, A., Rößling, G. and Brandi, M., Generation of contrast-carrying liposomes of defined size with a new continuous high pressure extrusion method. Int. J. Pharm., 117 (1995) 1-12.
21. Senior, J., Fate and behaviour of liposomes in vivo: a review of controlling factors. CRC Crit. Rev. Ther. Drug Carrier Syst., 3 (1987) 123-193.
22. Senior, J., Delgado, C., Fisher, D., Tilcock, C. and Gregoriadis, G., Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim. Biophys. Acta, 1062 (1991) 77-82.
23. Speck, U., X-ray contrast media: overview, use and pharmaceutical aspects. Product information, Schering AG, Berlin, Germany (1987).
24. Torchilin, V.P., Klibanov, A.L., Huang, L., O'Donnell, S., Nossif, N.D. and Khaw, B.A., Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J., 6 (1992) 2716-2719.
25. Weinmann, H.-J., Brasch, R.C., Press, W.-R. and Wesbey, G.E., Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. Am. J. Radiol., 142 (1984), 619-624.
26. Woodle, M.C., Storm, G., Newman, M.S., Jekot, J.J., Collins, L.R., Martin, F.J. and Szoka, F.C., Prolonged systemic delivery of peptide drugs by long-circulating liposomes: illustrated with vasopressin in the brattleboro rat. Pharm. Res., 9 (1992) 260-265.
27. Wu, N.Z., Da, D., Rudoll, T.L., Needham, D., Whorton, A.R. and Dewhirst, M.W., Increased microvascular permeability contributes to preferential accumulation of stealth liposomes in tumor tissues, Cancer Res., 53 (1993) 3765-3770.