Modelling and simulation of variability and uncertainty in toxicokinetics and pharmacokinetics

Toxicology Letters

Volumn 120, Issue 1-3, 2001, Pages 411-420

  Nestorov, Ivan ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Fuzzy; Monte Carlo; Simulation; Uncertainty; Variability

Indexed keywords

CONFERENCE PAPER; HUMAN; INFORMATION; MODEL; MULTIVARIATE ANALYSIS; NONHUMAN; POPULATION; PRIORITY JOURNAL; SAMPLE; SAMPLING; SIMULATION; STATISTICS; SYSTEM ANALYSIS; TOXICOKINETICS;

ANIMALS; HUMANS; MODELS, BIOLOGICAL; PHARMACOKINETICS; TOXICOLOGY;

EID: 0035977911     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00273-9     Document Type: Conference Paper

References (38)

1. Physiological modeling of Cyclosporine kinetics in rat and man
2. Quantitative structure pharmacokinetic relationships I. Development of whole body physiologically based pharmacokinetic model to characterise changes in pharmacokinetics across a homologous series of barbiturates in the rat
3. Comparison of three physiologically based pharmacokinetic models of benzene disposition
4. Analysis of PBPK models for risk characterization
5. Modeling human interindividual variability in metabolism and risk: The example of 4-Aminobiphenyl
6. Precision and sensitivity of pharmacokinetic models for cancer risk assessment: Tetrachlorethylene in mice, rats, and humans
7. Correlated inputs in quantitative risk assessment: The effects of distributional shape
8. Constructing membership functions using statistical data
9. Physiological parameters in laboratory animals and humans
10. Distribution of cardiac output during diurnal changes of activity in rats
11. Unfair coins and necessity measures: Towards a possibilistic interpretation of histograms
12. Evaluation of uncertainty in input parameters to pharmacokinetic models and the resulting uncertainty in output
13. Uncertainties in pharmacokinetic modeling of perchloroethylene. I. Comparison of model structure, parameters, and predictions for low-dose metabolism rates for models derived by different authors
14. Simulation in drug development: Good practices
15. Ventricular volumes and body weight in mammals
16. An approach to modelling and simulation of uncertain dynamical systems
17. Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model
18. Uncertainty, variability, and sensitivity analysis in physiological pharmacokinetic models
19. Regional blood flow in conscious resting rats determined by microsphere distribution
20. Adrenoreceptor effects on rat muscle blood flow during treadmill exercise
21. Suggested reference values for regional blood volumes in humans
22. Roles of cardiac output and peripheral resistance in mediating blood pressure response to stress in rats
23. Physiologically based pharmacokinetic modelling of a homologous series of barbiturates in the rat: A sensitivity analysis
24. Incorporating measures of variability and uncertainty into the prediction of in vivo hepatic clearance from in vitro systems
25. Measurement of the distribution of cardiac output in unanesthetized rats
26. Parameter variability and the interpretation of physiologically based pharmacokinetic modelling results
27. Scaling of respiratory variables in mammals
28. Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans
29. Structure and parameterization of pharmacokinetic models: Their impact on model predictions
30. Interspecies extrapolation of physiological pharmacokinetic parameter distributions
31. Cardiac output related to body weight in small mammals
32. Reference values for resting blood flow to organs of man
33. Uncertainty modelling and fuzzy sets