Structural and functional properties of aldose xylose reductase from the D-xylose-metabolizing yeast Candida tenuis

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 583-595

  Nidetzky, Bernd ^a   Mayr, Peter ^a   Neuhauser, Wilfried ^a   Puchberger, Michael ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

Aldo keto reductase; Specificity; Stereochemistry; Xylose metabolism

Indexed keywords

ALDEHYDE REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; XYLOSE;

AMINO ACID SEQUENCE; BINDING AFFINITY; CANDIDA; COENZYME; CONFERENCE PAPER; DISSOCIATION; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN FAMILY;

ALDEHYDE REDUCTASE; ALDEHYDES; AMINO ACID SEQUENCE; BINDING SITES; CANDIDA; CATALYTIC DOMAIN; HUMANS; HYDROGEN BONDING; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; NADP; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; XYLOSE;

CANDIDA TENUIS;

EID: 0035969838     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00285-4     Document Type: Conference Paper

References (37)

1. Microbial pentose utilization
2. Dual relationships of xylitol and alcohol dehydrogenases in families of two protein types
3. Structural and functional properties of a yeast xylitol dehydrogenase, a zinc-containing metalloenzyme similar to medium-chain sorbitol dehydrogenases
4. The structure and function of yeast xylose (aldose) reductases
5. Purification and partial characterization of an aldo-keto reductase from Saccharomyces cerevisiae
6. Comparative anatomy of the aldo-keto reductase superfamily
7. The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases
8. Short-chain dehydrogenases/reductases (SDR)
9. NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis
10. Xylose utilisation: Cloning and characterisation of the xylose reductase from Candida tenuis
11. Aldose reductase: Model for a new paradigm of enzymic perfection in detoxification catalysts
12. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications
13. Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: Enzyme kinetics and crystal structure of the Y48H mutant enzyme
14. Human aldose reductase: Rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme
15. Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110
16. Mutagenesis of 3α-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases
17. Molecular endocrinology of hydroxysteroid dehydrogenases
18. Overexpression and mutagenesis of the cDNA for rat liver 3α-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis
19. The crystal structure of the aldose reductase.NADPH binary complex
20. Three-dimensional structure of rat liver 3α-hydroxysteroid/dihydrodiol dehydrogenase: A member of the aldo-keto reductase superfamily
21. Human aldose reductase: Subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme
22. Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5′-phosphate and pyridoxal 5′-diphospho-5′-adenosine
23. Aldose reductase as a target for drug design: Molecular modeling calculations on the binding of acyclic sugar substrates to the enzyme
24. Refined 1.8 Å structure of human aldose reductase complexed with the potent inhibitor zopolrestat
25. Structural and kinetic determinants of aldehyde reduction by aldose reductase
26. Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain
27. 1.7 Å structure of FR-1, a fibroblast growth factor-induced member of the aldo-keto reductase family, complexed with coenzyme and inhibitor
28. Using high field NMR to determine dehydrogenase stereospecificity with respect to NADH
29. Mechanism of transfer of reduced nicotinamide adenine dinucleotide among dehydrogenases. Transfer rates and equilibria with enzyme-enzyme complexes
30. A heterologous reductase affects the redox balance of recombinant Saccharomyces cerevisiae
31. Noncovalent enzyme/substrate interactions in the catalytic mechanism of yeast aldose reductase
32. The use of fluoro- and deoxy-substrate analogs to examine binding specificity and catalysis in the enzymes of the sorbitol pathway
33. Hydrogen bonding and specificity. Fluorodeoxy sugars as probes of hydrogen bonding in the glycogen phosphorylase-glucose complex
34. Substrate specificity of human aldose reductase: Identification of 4-hydroxynonenal as an endogenous substrate
35. Binding energy, specificity, and enzymic catalysis
36. A new nomenclature for the aldo-keto reductase superfamily