Modulation of antigenicity related to changes in antibody flexibility upon lyophilization

Journal of Molecular Biology

Volumn 310, Issue 1, 2001, Pages 169-179

  Taschner, Nicole ^a   Müller, Shirley A ^a   Alumella, Venkateshwar R ^a   Goldie, Kenneth N ^b   Drake, Alex F ^c   Aebi, Ueli ^a   Arvinte, Tudor ^d  

^a UNIVERSITY OF BASEL   (Switzerland)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antibody flexibility; Lyophilization effects; Scanning transmission electron microscopy

Indexed keywords

ANTIBODY; ANTIGEN; ANTIIDIOTYPIC ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; TRYPTOPHAN;

ANISOTROPY; ANTIGENICITY; ARTICLE; CIRCULAR DICHROISM; DENATURATION; DRUG HALF LIFE; FLUORESCENCE; FREEZE DRYING; IMMUNOGENICITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TEMPERATURE DEPENDENCE;

EID: 0035967884     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4736     Document Type: Article

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