The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice

Chemico-Biological Interactions

Volumn 138, Issue 2, 2001, Pages 125-135

  Brown, Buddy G ^a   Richter, Elmar ^b   Tricker, Anthony R ^c   Ayres, Paul H ^a   Doolittle, David J ^a  

^a R J REYNOLDS TOBACCO COMPANY   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c Philip Morris Products SA   (Switzerland)

Author keywords

Cigarette smoke; Tobacco specific nitrosamine

Indexed keywords

4 (3 PYRIDYL) 4 HYDROXYBUTANOIC ACID; 4 (3 PYRIDYL) 4 OXOBUTANOIC ACID; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; 6 O METHYLGUANINE; BUTYRIC ACID; CIGARETTE SMOKE CONDENSATE; NITROSAMINE; PYRIDINE 1 OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CHEMICAL STRUCTURE; CIGARETTE SMOKING; CONTROLLED STUDY; FEMALE; GLUCURONIDATION; HYDROXYLATION; LUNG ADENOMA; METABOLIC ACTIVATION; MOUSE; NONHUMAN; OXIDATION; PARTICULATE MATTER; PROTO ONCOGENE; STATISTICAL ANALYSIS; TOBACCO;

ANIMALS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA; DNA ADDUCTS; DRUG INTERACTIONS; FEMALE; GUANINE; HYDROXYLATION; INJECTIONS, INTRAPERITONEAL; LIVER; LUNG; MICE; MICE, INBRED STRAINS; NITROSAMINES; TOBACCO SMOKE POLLUTION;

NICOTIANA TABACUM;

EID: 0035965553     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(01)00265-4     Document Type: Article

References (24)

1. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
2. Nitrosamines derived from nicotine and other tobacco alkaloids
3. Rapid single-dose model for lung tumor induction in A/J mice by 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet
4. 6-Methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung
5. G to A transitions and G-T transversions in codon 12 of the K-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents
6. 6-methylguanine DNA adduct levels and K-ras activation in lung tumors from resistant and susceptible mouse strains
7. Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse
8. Six-month exposure of strain A/J mice to cigarette sidestream smoke: Cell kinetics and lung tumor data
9. Tobacco smoke as a mouse lung carcinogen
10. 6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
11. Modernization of nose-only smoking machines for use in animal inhalation studies
12. Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats
13. Biliary excretion of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the rat
14. Characterization of a glucuronide metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats
15. Inhibition of mutagenicity of N-nitrosamines by tobacco smoke and its constituents
16. Effect of nicotine and tobacco-specific nitrosamines on the metabolism of N′-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by rat oral tissue
17. Effect of nicotine or cotinine on metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in isolated rat lung and liver
18. Effects of nicotine and cotinine on NNK metabolism in rats
19. Modulation of the uptake and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by nicotine in hamster lung
20. Modulation of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by hamster lung microsomes to protein alkylating species
21. Use of precision-cut tissue slices in organ culture to study metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by hamster lung, liver and kidney
22. Induction or respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation
23. The carcinogenicity of environmental tobacco smoke