Association of maspin expression with the malignancy grade and tumor vascularization in breast cancer tissues

Cancer Letters

Volumn 171, Issue 1, 2001, Pages 103-110

  Hojo, Takashi ^a,b   Akiyama, Yasuto ^a   Nagasaki, Koichi ^c   Maruyama, Kouji ^a   Kikuchi, Kiyoshi ^d   Ikeda, Tadashi ^b   Kitajima, Masaki ^b   Yamaguchi, Ken ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF KIEL   (Germany)

^d Tokyo Denryoku Hospital   (Japan)

Author keywords

Angiogenesis; Breast cancer; Maspin; Myoepithelial cell; Tumor suppression

Indexed keywords

MASPIN; VON WILLEBRAND FACTOR;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CANCER INFILTRATION; CANCER TISSUE; CLINICAL ARTICLE; CLINICAL FEATURE; DISEASE ASSOCIATION; FEMALE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MYOEPITHELIUM CELL; ONCOGENE NEU; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TUMOR VASCULARIZATION;

BREAST NEOPLASMS; CARCINOMA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN BIOSYNTHESIS; PROTEINS; RECEPTOR, ERBB-2; SERPINS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; VON WILLEBRAND FACTOR;

EID: 0035964452     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00569-9     Document Type: Article

References (20)

1. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells
2. Production, purification, and characterization of recombinant maspin proteins
3. Immunohistochemical detection of maspin is a useful adjunct in distinguishing radical sclerosing lesion from tubular carcinoma of the breast
4. Function of maspin
5. Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells
6. Maspin suppresses the invasive phenotype of human breast carcinoma
7. The human myoepithelial cell is a natural tumor suppressor
8. p53 regulates the expression of the tumor suppressor gene maspin
9. Maspin is an angiogenesis inhibitor
10. The human myoepithelial cell exerts antiproliferative effects on breast carcinoma cells characterized by p21WAF1/CIP1 induction, G2/M arrest, and apoptosis
11. Breast cancer
12. Tumor angiogenesis in chronic pancreatitis and pancreatic adenocarcinoma: Impact of K-ras mutations
13. Maspin plays an important role in mammary gland development
14. Maspin is an intracellular serpin that partitions into secretary vesicles and is present at the cell surface
15. Characterizations of the extracellular matrix and proteinase inhibitor content of human myoepithelial tumors
16. Epigenetic silencing of maspin gene expression in human breast cancers
17. Concordance between p53 protein overexpression and gene mutation in larger series of common human carcinomas
18. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma