Reduction in mortality from heartwater in cattle, sheep and goats exposed to field challenge using an inactivated vaccine

Veterinary Parasitology

Volumn 97, Issue 4, 2001, Pages 295-308

  Mahan, Suman M ^a,b   Smith, Gillian E ^a   Kumbula, David ^a   Burridge, Michael J ^b   Barbet, Anthony F ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b University of Florida College of Veterinary Medicine   (United States)

Author keywords

Amblyomma hebraeum; Amblyomma variegatum; Cattle; Cowdria ruminantium; Field trials; Goats; Heartwater; Inactivated vaccine; Sheep; Southern Africa

Indexed keywords

INACTIVATED VACCINE;

AMBLYOMMA; ANIMAL EXPERIMENT; ANIMAL HUSBANDRY; ANIMAL MODEL; ARTICLE; CATTLE; CONTROLLED STUDY; GOAT; HEARTWATER DISEASE; MORTALITY; NONHUMAN; SHEEP; SURVIVAL; TREATMENT OUTCOME;

ACARI; AMBLYOMMA; AMBLYOMMA HEBRAEUM; AMBLYOMMA VARIEGATUM; ANIMALIA; BOS TAURUS; CAPRA HIRCUS; EHRLICHIA; EHRLICHIA RUMINANTIUM; OVIS ARIES;

EID: 0035963611     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4017(01)00437-X     Document Type: Article

References (26)

1. Improved culture conditions for Cowdria ruminantium (Rickettsiales), the agent of heartwater disease of domestic ruminants
2. In vitro isolation of Cowdria ruminantium from plasma of infected ruminants
3. Heartwater in angora goats. I. Immunity subsequent to artificial infection and treatment
4. Antigenic differences between stocks of Cowdria ruminantium
5. Antigenic diversity of Cowdria ruminantium isolates determined by cross-immunity
6. The effects of the war on the control of diseases of livestock in Rhodesia (Zimbabwe)
7. Protein measurement with the Folin phenol reagent
8. An immunoblotting diagnostic assay for heartwater based on the immunodominant 32 kD protein of Cowdria ruminantium detects false positives in field sera
9. Conconavalin a-stimulated bovine T-cell supernatants inhibit growth of Cowdria ruminantium in bovine endothelial cells in vitro
10. Immunization of sheep with inactivated Cowdria ruminantium provides protection against heartwater
11. The inactivated Cowdria ruminantium vaccine for heartwater protects against heterologous strains and against laboratory and field tick challenge
12. Protection of goats against heartwater acquired by immunisation with inactivated elementary bodies of Cowdria ruminantium
13. Comparative efficacy of Freund's and Montanide ISA50 adjuvants for the immunisation of goats against heartwater with inactivated Cowdria ruminantium
14. An assessment of the economic impact of heartwater (Cowdria ruminantium infection) and its control in Zimbabwe
15. The distribution of heartwater in the highveld of Zimbabwe, 1980-1997
16. Distributions of the vectors of heartwater, Amblyomma hebraeum and Amblyomma variegatum (Acari: Ixodidae), in Zimbabwe
17. Prevalence of Cowdria ruminantium infection in Amblyomma hebraeum ticks from heartwater-endemic areas of Zimbabwe
18. Detection of the agent of heartwater, Cowdria ruminantium, in Amblyomma ticks by PCR: Validation and application of the assay to field ticks
19. A simple and rapid method for demonstrating Rickettsia ruminantium (Cowdry, 1925) in heartwater brains
20. Evidence to show that an agent that cross-reacts serologically with Cowdria ruminantium in Zimbabwe is transmitted by ticks
21. Analysis of T-cell responses in cattle immunised against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium
22. Heartwater (Cowdria ruminantium infection): Current status
23. Use of a specific immunogenic region on the Cowdria ruminantium MAP1 protein in a serological assay
24. Heartwater: Cross immunity studies with strains of Cowdria ruminantium isolated in west and South Africa
25. The tick vectors of Cowdria ruminantium (Ixodoidea, Ixodidae, genus Amblyomma) and their distribution