Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721

Tetrahedron Letters

Volumn 42, Issue 22, 2001, Pages 3681-3684

  Madar, David J ^a   Kopecka, Hana ^a   Pireh, Daisy ^a   Pease, Jonathan ^a   Pliushchev, Marina ^a   Sciotti, Richard J ^a   Wiedeman, Paul E ^a   Djuric, Stevan W ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; HYDROXYMETHYL 2 OXALIDINONE; N [[3 (4 ACETYLPHENYL) 2 OXO 5 OXAZOLIDINYL]METHYL]ACETAMIDE; OXAZOLIDINE DERIVATIVE; PALLADIUM; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 0035963004     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(01)00559-7     Document Type: Article

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10. +. This procedure has been run on a 'process scale' with 145 g of 7 in 64% yield. DMF was a more convenient solvent for the reaction.
11. Urea 17 was formed in high yield from the displacement of the tosylate derived from 5 with 2,4-dimethoxybenzylamine in DMSO at 40°C, followed by treatment with acetic anhydride/pyridine.
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