The metabolism and bioactivation of agaritine and of other mushroom hydrazines by whole mushroom homogenate and by mushroom tyrosinase

Toxicology

Volumn 161, Issue 3, 2001, Pages 165-177

  Walton, Kim ^a   Coombs, Maurice M ^a   Walker, Ron ^a   Ioannides, Costas ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Agaricus bisporus; Agaritine; Hydrazines; Mushroom; Tyrosinase bioactivation

Indexed keywords

4 (HYDROXYMETHYL)PHENYLHYDRAZINE; AGARITINE; DRUG METABOLITE; GAMMA GLUTAMYLTRANSFERASE; HYDRAZINE AGARITINE; HYDRAZINE DERIVATIVE; MONOPHENOL MONOOXYGENASE; N' ACETYL 4 (HYDROXYMETHYL)PHENYLHYDRAZINE; UNCLASSIFIED DRUG;

AGARICUS BISPORUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVATION; ENZYME METABOLISM; GENOTOXICITY; MOUSE; MUSHROOM; MUSHROOM POISONING; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; TOXIN ANALYSIS;

AGARICALES; BIOTRANSFORMATION; HYDRAZINES; MONOPHENOL MONOOXYGENASE; MUTAGENICITY TESTS; MUTAGENS; PHENYLHYDRAZINES;

AGARICUS BISPORUS; BASIDIOMYCOTA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0035961953     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00430-3     Document Type: Article

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3. Mammalian tyrosinase-the critical regulatory control point in melanocyte pigmentation
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6. Agaritine content of fresh and processed mushrooms [Agaricus bisporus (Lange) Imbach]
7. Protein determination with the Folin phenol reagent
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13. Tyrosinase: A comprehensive review of its mechanism
14. Laccase, and not tyrosinase is the enzyme responsible for quinone methide production from 2,6-dimetnoxy-4-allyl phenol
15. Toxicities of hydrazines: A review
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18. Carcinogenesis by the cultivated baked Agaricus bisporus mushroom in mice
19. An improved synthesis of agaritine
20. Attempted tumor induction with agaritine in mice
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22. An improved synthesis of agaritine
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24. Bioactivation of the mushroom hydrazine, agaritine, to intermediates that bind covalently to proteins and induce mutations in the Ames test
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26. The fate of the mushroom hydrazine, agaritine, in the rat and mouse