Process development of potassium channel opener, TCV-295, based on convenient ring formation of 2H-1,3-benzoxazine and selective N-oxidation of the pyridyl moiety

Tetrahedron

Volumn 57, Issue 35, 2001, Pages 7501-7506

  Mizufune, Hideya ^a   Irie, Hiroyuki ^a   Katsube, Susumu ^a   Okada, Tadataka ^a   Mizuno, Yukio ^a   Arita, Miichiro ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Amines; Ammonium salts; Benzoxazines; Dioxiranes; N oxides

Indexed keywords

2 (6 BROMO 7 CHLORO 2,2 DIMETHYL 2H 1,3 BENZOXAZIN 4 YL)PYRIDINE 1 OXIDE; 2 HYDROXYBENZOYLPYRIDINE; 2 HYDROXYPHENYLKETONE DERIVATIVE; 2,2 DIMETHOXYPROPANE; 2H 1,3 BENZOXAZINE; 2H 1,3 BENZOXAZINE DERIVATIVE; 4 (2 PYRIDYL) 2H 1,3 BENZOXAZINE DERIVATIVE; AMINE; AMMONIUM HALIDE; AMMONIUM IODIDE; BENZALDEHYDE; DIMETHYLDIOXIRANE; HALIDE; IODINE DERIVATIVE; KETONE DERIVATIVE; PIPERIDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; PYRIDINE DERIVATIVE; TCV 295; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0035959458     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(01)00728-1     Document Type: Article

References (16)