Orphanin-FQ/nociceptin inhibits kindling epileptogenesis and enhances hippocampal feed-forward inhibition

Neuroscience

Volumn 105, Issue 2, 2001, Pages 325-333

  Gutierrez R ^a   Leff, P ^b   Romo Parra, H ^a   Acevedo, R ^b   Anton B ^b  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUTO NACIONAL DE PSIQUIATRÍA RAMÓN DE LA FUENTE MUÑIZ   (Mexico)

Author keywords

Epilepsy; Feed forward inhibition; Immunohistochemistry; Kindling; Limbic system; Orphanin FQ nociceptin

Indexed keywords

NALOXONE; NOCICEPTIN; NOCICEPTIN DERIVATIVE; OPIATE ANTAGONIST; RABBIT ANTISERUM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ELECTROSTIMULATION; EPILEPSY; EPILEPTOGENESIS; EXCITABILITY; GRAND MAL SEIZURE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KINDLING; LIMBIC CORTEX; NEGATIVE FEEDBACK; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRIFORM CORTEX; RAT; SYNAPTIC TRANSMISSION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EPILEPSY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; KINDLING, NEUROLOGIC; NALOXONE; NARCOTIC ANTAGONISTS; NEURAL INHIBITION; NEURONS; OLFACTORY PATHWAYS; OPIOID PEPTIDES; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; SYNAPTIC TRANSMISSION;

EID: 0035958654     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00196-8     Document Type: Article

References (35)

1. Orphanin FQ-induced outward current in rat hippocampus
2. Immunohistochemical localization of ORL-1 in the central nervous system of the rat
3. Feed-forward inhibition in the hippocampal formation
4. Termination of epileptic afterdischarge in the hippocampus
5. Interictal behavioral disturbances: A search for molecular substrates
6. Naloxone facilitates sensory precipitation of focal and generalized seizures. Evoked potentials and power spectral analysis in the cat
7. Endogenous opioids may mediate post-ictal behavioral depression in amygdaloid-kindled rats
8. A new selective antagonist of the nociceptin receptor
9. Seizures induce simultaneous GABAergic and glutamatergic neurotransmission in the dentate gyrus-CA3 system
10. Is excitation by enkephalins of hippocampal neurones in the rat due to presynaptic facilitation or to disinhibition?
11. The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ
12. Selected methods for antibody and nucleic acid probes
13. Structure and regional distribution of nociceptin/orphanin FQ precursor
14. A comprehensive immunohistochemical mapping of nociceptin-/orphanin FQ peptide in the CNS of the rat
15. Peptide detection in single cells using dot immunoblot assay
16. Differential effects of mu- and delta-receptor selective opioid agonists on feedforward and feedback GABAergic inhibition in hippocampal brain slices
17. Nociceptin augments K(+) currents in hippocampal CA1 neurons by both ORL-1 and opiate receptor mechanisms
18. Localization of endomorphin-2-like immunoreactivity in the rat medulla and spinal cord
19. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene
20. Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]-orphanin FQ binding
21. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
22. On the potassium conductance increased by opioids in rat locus coeruleus neurones
23. Primary structure and tissue distribution of the orphanin FQ precursor
24. Repeated tetanic stimulation in piriform cortex in vitro: Epileptogenesis and pharmacology
25. Epileptogenesis and hypertonic post-ictal phenomena induced by naloxone in intact cats
26. Modification of seizure activity by electrical stimulation. II. Motor seizure
27. Endogenous opioid peptides and epilepsy
28. Role of the hippocampus in epilepsy
29. Morphine and enkephalin: Analgesic and epileptic properties
30. Brain content of leu5- and met5-enkephalin changes independently during the development of kindling in the rat
31. Opioid peptides selective for mu- and delta-opiate receptors reduce calcium-dependent action potential duration by increasing potassium conductance
32. Orphanin FQ/nociceptin inhibits synaptic transmission and long-term potentiation in rat dentate gyrus through postsynaptic mechanisms
33. Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus