Direct inhibition of voltage-dependent Ca2+ fluxes by ethanol and higher alcohols in rabbit T-tubule membranes

European Journal of Pharmacology

Volumn 418, Issue 3, 2001, Pages 169-176

  Oz, Murat ^c   Tchugunova, Yulia B ^a   Dunn, Susan M J ^b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Alcohol; Ca2+ channel; Ethanol; Skeletal muscle

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; ALCOHOL; BUTANOL; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM ION; DECANOL; DIHYDROPYRIDINE DERIVATIVE; HEXANOL; LANTHANUM; LAURYL ALCOHOL; NIFEDIPINE; OCTANOL; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; UNDECANOL;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; INHIBITION KINETICS; LIGAND BINDING; MUSCLE FIBER MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RABBIT; REGULATORY MECHANISM; SKELETAL MUSCLE; TRANSVERSE TUBULAR SYSTEM;

ALCOHOLS; ANIMALS; BINDING, COMPETITIVE; BUTANOLS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM RADIOISOTOPES; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ETHANOL; HEXANOLS; ISRADIPINE; LANTHANUM; NIFEDIPINE; OCTANOLS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035957705     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00945-1     Document Type: Article

References (37)

1. Abdel-Latif A.A. Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers. Pharmacol. Rev. 38:1986;227-272.
2. Canda A., Yu B.H., Sze P.Y. Biochemical characterization of ethanol actions on dihydropyridine-sensitive calcium channels in brain synaptosomes. Biochem. Pharmacol. 50:1995;1711-1718.
3. 2+ channels. Science. 242:1988;50-61.
4. Cofan M., Nicolas J.M., Fernandez-Sola J., Robert J., Tobias E., Sacanella E., Estruch R., Urbano-Marquez A. Acute ethanol treatment decreases intracellular calcium-ion transients in mouse single skeletal muscle fibers in vitro. Alcohol Alcohol. 35:2000;134-138.
5. Coronado R. Planer bilayer reconstitution of calcium channels: lipid effects on single-channel kinetics. Circ. Res. 61:1987;I46-I52.
6. Dirksen R.T., Beam K.G. Single calcium channel behavior in native skeletal muscle. J. Gen. Physiol. 105:1995;227-247.
7. Dunn S.M.J. Voltage-dependent calcium channels in skeletal muscle transverse tubules: measurements of calcium efflux in membrane vesicles. J. Biol. Chem. 264:1989;11053-11060.
8. Dunn S.M.J., Bhat M., Oz M. The molecular structure and gating of calcium channels. Foa P., Walsh M. Ion Channels and Ion Transport. 1994;1-18 Springer-Verlag, New York, NY.
9. 2+ current of skeletal muscle. Pfluegers Arch. 425:1993;54-61.
10. Flockerzi V., Oeken H.J., Hofmann F., Pelzer D., Cavalie A., Trautwein W. Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional channel. Nature. 323:1986;66-68.
11. 3H]Nitrendipine receptors in skeletal muscle: properties and preferential localization in transverse tubules. J. Biol. Chem. 10:1983;6086-6092.
12. Franks N.P., Lieb W.R. Mapping of general anaesthetic target sites provides a molecular basis for cut-off effects. Nature. 316:1985;349-351.
13. Franks N.P., Lieb W.R. Molecular and cellular mechanisms of general anaesthesia. Nature. 367:1994;607-614.
14. 2+ channels in frog skeletal muscle (Rana pipiens). Pfluegers Arch. 408:1987;646-648.
15. 3H]nitrendipine binding to calcium channels in brain membranes. Alcohol.: Clin. Exp. Res. 8:1984;568-571.
16. + currents in the guinea-pig heart. Eur. J. Pharmacol. 292:1995;143-149.
17. 2+ channels. Eur. J. Pharmacol. 229:1992;143-148.
18. Lamb G.D., Walsh T. Calcium currents, charge movement and dihydropyridine binding in fast- and slow-twitch muscle of rat and rabbit. J. Physiol. (London). 393:1987;595-617.
19. Lovinger D.M. Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;267-282.
20. Mlinar B., Enyeart J.J. Block of current through T-type calcium channels by trivalent metal cations and nickel in neuronal rat and human cells. J. Physiol. (London). 469:1993;639-652.
21. Nicolas J.M., Antunez E., Thomas A.P., Fernandez-Sola J., Tobias E., Estruch R., Urbano-Marquez A. Ethanol acutely decreases calcium transients in cultured human myotubes. Alcohol.: Clin. Exp. Res. 22:1998;1086-1092.
22. Ohnishi S.T., Flick J.L., Rubin E. Ethanol increases calcium permeability of heavy sarcoplasmic reticulum of skeletal muscle. Arch. Biochem. Biophys. 233:1984;588-594.
23. Oz M., Frank G.B. Decrease in the size of tetanic responses by nitrendipine or by extracellular calcium ion removal without blocking twitches or action potentials in skeletal muscle. J. Pharmacol. Exp. Ther. 257:1991;575-581.
24. Oz M., Frank G.B. Frequency-dependent effect of ethanol on action potentials of frog skeletal muscle fibers. Methods Find. Exp. Clin. Pharmacol. 17:1995;295-298.
25. 45Ca efflux studies in rabbit t-tubule membrane preparations in the range of late after potentials during contractions. Frank G.B., Bianchi C.P., ter Keurs H.E.D.J. Excitation-Contraction Coupling in Skeletal, Cardiac and Smooth Muscle. 1992;419-421 Plenum, New York, NY.
26. Oz M., Frank G.B., Dunn S.M.J. Voltage-dependent calcium flux across rabbit skeletal muscle transverse tubule membranes in the range of late after potentials. Can. J. Physiol. Pharmacol. 71:1993;518-521.
27. 2+ sensors. Mol. Pharmacol. 54:1998;1106-1112.
28. Pagala M., Ravindran K., Amaladevi B., Namba T., Grob D. Effect of ethanol in function of the rat heart and skeletal muscle. Alcohol.: Clin. Exp. Res. 19:1995;676-684.
29. Peoples R.W., Chaoying L., Weight F.F. Lipid vs protein theories of alcohol action in the nervous system. Annu. Rev. Pharmacol. Toxicol. 36:1996;185-201.
30. Rabe C.S., Weight F.F. Effects of ethanol on neurotransmitter release and intracellular free calcium in PC12 cells. J. Pharmacol. Exp. Ther. 244:1988;417-422.
31. Requena J., Velaz M.E., Guerrero J.R., Medina J.D. Isomers of long-chain alkane derivatives and nervous impulse blockade. J. Membr. Biol. 84:1985;229-238.
32. Rodriguez N., Villegas R., Requena J. The interaction of homologous series of alkanols with sodium channels in nerve membrane vesicles. J. Membr. Biol. 104:1988;139-146.
33. Rosemblatt M.S., Scales D.J. Morphological, immunological and biochemical characterization of purified transverse tubule membranes isolated from rabbit skeletal muscle. Mol. Cell. Biochem. 87:1989;57-69.
34. 2+ channel inactivation. J. Biol. Chem. 273:1998;957-963.
35. Wafford K.A., Dunwiddie T.V., Harris R.A. Calcium-dependent chloride currents elicited by injection of ethanol into Xenopus oocytes. Brain Res. 505:1989;215-219.
36. Walter H.J., Messing R.O. Regulation of neuronal voltage-gated calcium channels by ethanol. Neurochem. Int. 35:1999;95-101.
37. Weight F.F. Cellular and molecular physiology of alcohol actions in the nervous system. Int. Rev. Neurobiol. 33:1992;289-348.