Transient disruption of spermatogenesis by deregulated expression of neurturin in testis

Molecular and Cellular Endocrinology

Volumn 184, Issue 1-2, 2001, Pages 33-39

  Meng, Xiaojuan ^a   Pata, Illar ^a,b   Pedrono, Eric ^a   Popsueva, Anna ^a   De Rooij, Dirk G ^c   Jänne, Marja ^d   Rauvala, Heikki ^d   Sariola, Hannu ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TARTU   (Estonia)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

GDNF family receptor ; Glial cell line derived neurotrophic factor; Neurturin; Ret receptor tyrosine kinase; Spermatogenesis

Indexed keywords

COMPLEMENTARY DNA; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIC FACTOR; NEURTURIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GERM CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM;

ANIMALS; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; MALE; MICE; MICE, TRANSGENIC; NERVE GROWTH FACTORS; NEURTURIN; PHENOTYPE; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, MESSENGER; SPERMATOGENESIS; SPERMATOGONIA; TESTIS;

EID: 0035955869     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00649-9     Document Type: Article

References (26)

1. GDNF family neurotrophic factor signalling: Four masters, one servant?
2. Growth factors as autocrine and paracrine modulators of male gonadal functions
3. Differential localisation of fibroblast growth factor receptor-1, -2, -3 and -4 in fetal, immature, and adult rat testes
4. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
5. Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia
6. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons
7. A role for oestrogens in the male reproductive system
8. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor
9. Neurturin, a relative of glial-cell-line-derived neurotrophic factor
10. A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
11. Regulation of cell fate decision of undifferentiated spermatogonia by GDNF
12. Promotion of seminomatous tumors by targeted overexpression of GDNF in mouse testis
13. pEF-BOS, a powerful mammalian expression vector
14. Multicomponent receptors for the GDNF/Neurturin protein family
15. Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR2, a functional neurturin receptor
16. GDNF triggers a novel Ret-independent Src kinase family-coupled signaling via a GPI-liked GDNF receptor α1
17. Other neurotrophic factors: Glial cell line-derived neurotrophic factor (GDNF)
18. Ret-dependent and independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
19. Glial cell line-derived neurotrophic factor and neurturin can act as paracrine growth factors stimulating DNA synthesis of Ret-expressing spermatogonia
20. Neurturin and glial cell line-derived neurotrophic factor receptor α (GDNFRα), novel proteins related to GDNF and GDNFR-α with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs
21. Neurturin, RET, GFRα-1 and GFRα-2, but not GFRα-3, mRNA are expressed in mice gonads
22. In situ hybridisation and the three-dimensional reconstruction of serial sections
23. The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse
24. Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and in the integrity of the epididymis