Doxycycline-induced inhibition of prolidase activity in human skin fibroblasts and its involvement in impaired collagen biosynthesis

European Journal of Pharmacology

Volumn 430, Issue 1, 2001, Pages 25-31

  Karna, Ewa ^a   Palka, Jerzy ^a   Wolczyński, Slawomir ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Collagen; Doxycycline; Fibroblast; Prolidase

Indexed keywords

BETA1 INTEGRIN; COLLAGEN; DIPEPTIDE; DOXYCYCLINE; EXOPEPTIDASE; INTEGRIN RECEPTOR; MANGANESE; PROLINE; PROLINE DIPEPTIDASE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL VIABILITY; COLLAGEN METABOLISM; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SKIN FIBROBLAST;

ANTI-BACTERIAL AGENTS; ANTIGENS, CD29; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN; DIPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; ENZYME INHIBITORS; FIBROBLASTS; GELATIN; HUMANS; SKIN; TIME FACTORS;

EID: 0035955353     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01372-3     Document Type: Article

References (35)

1. Extracellular matrix degradation
2. Prolidase deficiency. Biochemical classification of alleles
3. Expression of activated gelatinase in human invasive breast carcinoma
4. Evaluation of a tetrazolinum-based semiautomated colorimetric assay: Assessment of chemosensitivity testing
5. Collagen biosynthetic anomalies in prolidase deficiency: Effect of glycyl-L-proline on the degradation of newly synthesized collagen
6. Photometric estimation of proline and ornithine
7. Doxycycline disrupts chondrocyte differentiation and inhibits cartilage matrix degradation
8. Doxycycline inhibits type X collagen synthesis in avian hypertrophic chondrocyte cultures
9. Primary structure and gene localization of human prolidase
10. Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs
11. Host modulation with tetracyclines and their chemically modified analogues
12. A syndrome resembling lathyrism associated with iminodipeptiduria
13. A 13C nuclear magnetic resonance analysis of the metal binding site in tetracycline
14. Iminopeptiduria. A genetic defect in recycling collagen: A method for determining prolidase in red blood cells
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Protein measurement with the Folin phenol reagent
17. Growth-dependent modulation of type I collagen production and mRNA levels in cultured human skin fibroblasts
18. Inhibition of prolidase activity by non-steroid anti-inflammatory drugs in cultured human skin fibroblasts
19. The mechanism for antracycline-induced inhibiton of collagen biosynthesis
20. Optimal conditions for prolidase assay by proline colorimetric determination: Application to imidodipeptiduria
21. A cell density affects prolidase and prolinase activity and intracellular amino acid levels in cultured human cells
22. 4 administration inducing liver cytolysis and fibrosis in rat
23. Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis
24. Scorbutic and fasted guinea pig sera contain an insulin-like growth factor-I reversible inhibitor of proteoglycan and collagen synthesis in chick embryo chondrocytes and adult human skin fibroblasts
25. Prolidase activity in fibroblasts is regulated by interaction of extracellular matrix with cell surface integrin receptors
26. Modulation of prolidase activity during in vitro aging of human skin fibroblasts. The role of extracellular matrix collagen
27. Fibroblast chemotaxis and prolidase activity modulation by insulin-like growth factor II and mannose 6-phosphate
28. Determination of collagen synthesis in tissue and cell culture system
29. Disorders of proline and hydroxyproline metabolism
30. Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage
31. Mechanism of collagen degradation by collagenase: A transition process of the collagen molecule from collagenase substrate to gelatinase substrate
32. Reorganization of polymerized actin: A possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels
33. A proton nuclear magnetic resonance study of the site of metal binding in tetracycline
34. Proline-dependent structural and biological properties of peptides and proteins
35. Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline