Truncation of the human adenovirus type 5 L4 33-kDa protein: Evidence for an essential role of the carboxy-terminus in the viral infectious cycle

Virology

Volumn 289, Issue 2, 2001, Pages 388-399

  Finnen, Renée L ^a   Biddle, Jennifer F ^a   Flint, Jane ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN L4; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ADENOVIRUS 5; ARTICLE; CARBOXY TERMINAL SEQUENCE; HUMAN; HUMAN CELL; LETHALITY; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSCRIPTION REGULATION; VIRION; VIRUS ASSEMBLY; VIRUS INFECTION; VIRUS MUTANT;

ADENOVIRIDAE; HUMAN ADENOVIRUS; HUMAN ADENOVIRUS TYPE 5; SUBGROUP C;

EID: 0035950604     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.1130     Document Type: Article

References (83)

1. Adenovirus 5 DNA sequences present and RNA sequences transcribed in transformed human embryo kidney cells (HEK-Ad-5 or 293)
2. Processing of adenovirus 2-induced proteins
3. Phosphoproteins of adenovirus 2
4. Nuclear organization of replication and gene expression in adenovirus-infected cells
5. Sequence and transcriptional analysis of terminal regions of the fowl adenovirus type 8 genome
6. Principles of virion structure, function, and assembly
7. Control mechanisms in dsDNA bacteriophage assembly
8. Sequence of the mouse adenovirus type-1 DNA encoding the 100-kDa, 33-kDa and DNA-binding proteins
9. Immunoprecipitation with two-dimensional pools as a hybridoma screening technique: Production and characterization of monoclonal antibodies against adenovirus 2 proteins
10. Assembly of adenovirus major capsid protein is mediated by a nonvirion protein
11. Analysis of Ad5 hexon and 100K ts mutants using conformation-specific monoclonal antibodies
12. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli
13. The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2
14. Genomic sequencing
15. The DNA sequence of adenovirus type 40
16. Virus assembly
17. Adenovirus type 2 assembly analyzed by reversible cross-linking of labile intermediates
18. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
19. Superimposed promoter sequences of the adenoviral E2E RNA polymerase III and RNA polymerase II transcription units
20. Intermediates in adenovirus assembly
21. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
22. The role of the L4 33K gene in adenovirus infection
23. Regulation of adenovirus mRNA formation
24. Comparison of viral RNA sequences in adenovirus 2-transformed and lytically infected cells
25. Late nonstructural 100,000- and 33,000-dalton proteins of adenovirus type 2. I. Subcellular localization during the course of infection
26. Late nonstructural 100,000- and 33,000-dalton proteins of adenovirus type 2. II. Immunological and protein chemical analysis
27. Site-directed mutation affecting polyomavirus capsid self-assembly in vitro
28. A new technique for the assay of infectivity of human adenovirus 5 DNA
29. 2 gene product during infection
30. Encapsidation of viral DNA requires the adenovirus L1 52/55-kilodalton protein
31. Encapsidation of adenovirus 16 DNA is directed by small DNA sequence at the left end of the genome
32. Monoclonal antibodies specific for adenovirus early region 1A proteins: Extensive heterogeneity in early region 1A products
33. Adenovirus L1 52-and 55-kilodalton proteins are present within assembling virions and colocalize with nuclear structures distinct from replication centers
34. Adenovirus L1 52- and 55-kilodalton proteins are required for assembly of virions
35. The origin of adenovirus DNA replication: Minimal DNA sequence requirement in vivo
36. The adenovirus L4 100-kilodalton protein is necessary for efficient translation of viral late mRNA species
37. Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome
38. The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element
39. Selective extraction of polyoma DNA from infected mouse cell cultures
40. In vivo transcription from the adenovirus E2 early promoter by RNA polymerase III
41. The polypeptides of adenovirus. V. Young virions, structural intermediates between top components and aged virions
42. Morphogenesis of poliovirus. I. Association of the viral RNA with coat protein
43. Transcriptional modulation by the adenovirus E1A gene
44. Anatomy of an unusual RNA polymerase II promoter containing a downstream TATA element
45. The procapsid-to-capsid transition in double-stranded DNA bacteriophages
46. The structure of replicating adenovirus 2 DNA molecules
47. Specific transcription of an adenoviral gene that possesses no TATA sequence homology in extracts of HeLa cells
48. High level transcription from the adenovirus major late promoter requires downstream binding sites for late-phase-specific factors
49. 2 gene product, an effector of late phase-dependent activation of the major late promoter
50. The polypeptides of adenovirus II. Soluble proteins, cores, top components and structure of the virion
51. Downstream sequences affect transcription initiation from the adenovirus major late promoter
52. Electron microscopy of adenovirus 12 replication. I. Fine structural changes in the nucleus of infected KB cells
53. Electron microscopy of adenovirus 12 replication. II. High-resolution autoradiography of infected KB cells labeled with tritiated thymidine
54. Localization of simian adenovirus 7 (SA7) transcription and replication in lytic Infection: An ultracytochemical and autoradiographical study
55. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
56. RNA binding properties of poliovirus subviral particles
57. Identification of the in vitro translation products of adenovirus mRNA by immunoprecipitation
58. Polypeptide structure and encoding location of the adenovirus serotype 2 late, non-structural 33K protein
59. Characterization of two temperature-sensitive mutants of type 5 adenovirus with mutations in the 100,000-dalton protein gene
60. Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: Association with nuclear viral inclusions requires the early region 4 34-kilodalton protein
61. A maturation protein in adenovirus morphogenesis
62. Structural proteins of adenoviruses. III. Characterization of incomplete particles of adenovirus type 3
63. Specific transcription from the adenovirus E2E promoter by RNA polymerase III requires a subpopulation of TFIID
64. Monoclonal antibodies which recognize native and denatured forms of the adenovius DNA-binding protein
65. Incomplete particles of adenovirus II. Kinetics of formation and polypeptide composition of adenovirus type 2
66. Polypeptide phosphorylation in adenovirus-infected cells
67. A monoclonal antibody detecting the adenovirus type 5-E1b-58Kd tumor antigen: Characterization of the E1b-58Kd tumor antigen in adenovirus-infected and -transformed cells
68. Transcripts from the adenovirus-2 major late promoter yield a single early family of 3′ co-terminal mRNAs and five late families
69. Adenoviridae and their replication
70. Transcriptional and transforming activities of the adenovirus E1A proteins
71. Nucleotide sequence of the region coding for 100K and 33K proteins of human enteric adenovirus type 41 (Tak)
72. Herpesvirus capsid assembly and envelopment
73. Immunofluorescence study of the adenovirus type 2 single-stranded DNA binding protein in infected and transformed cells
74. Assembly of adenoviruses
75. 2 is a transcription activator of the major late promoter
76. Adenovirus DNA replication
77. Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA
78. Identification of two nuclear subclasses of the adenovirus type 5-encoded DNA-binding protein
79. Sequence of ovine adenovirus homologs for 100K hexon assembly, 33K, pVIII, and fiber genes: Early region E3 is not in the expected location
80. Regulation of p53-dependent apoptosis by E1A and E1B
81. 2
82. Immune responses to adenoviruses: Viral evasion mechanisms and their implications for the clinic
83. 2 protein with viral packaging sequences