Plate-based dormancy culture system for Mycobacterium smegmatis and isolation of metronidazole-resistant mutants

FEMS Microbiology Letters

Volumn 200, Issue 2, 2001, Pages 215-219

  Lim, Amanda ^a   Dick, Thomas ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

Dormancy; Drug resistance; Metronidazole

Indexed keywords

METRONIDAZOLE;

ANAEROBIC BACTERIUM; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATION; BACTERIUM MUTANT; DRUG EFFECT; GENETIC ANALYSIS; HALF LIFE TIME; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL; SURVIVAL;

ANTI-BACTERIAL AGENTS; CULTURE MEDIA; DRUG RESISTANCE, MICROBIAL; METRONIDAZOLE; MUTATION; MYCOBACTERIUM SMEGMATIS; SELECTION (GENETICS);

EID: 0035948223     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(01)00231-2     Document Type: Article

References (11)

1. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
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3. Oxygen depletion induced dormancy in Mycobacterium smegmatis
4. Dormant tubercle bacilli: The key to more effective TB chemotherapy?
5. Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis
6. Metronidazole therapy in mice infected with tuberculosis
7. Why metronidazole is active against both bacteria and parasites
8. Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis
9. Stimulation of transposition of the insertion sequence IS6110 by exposure to a microaerobic environment
10. Genetic antagonism and hypermutability in Mycobacterium smegmatis
11. Insertional mutagenesis by electroporation of released Tn5 transposition complex