Pharmacokinetics of MDL 26479, a novel benzodiazepine inverse agonist, in normal volunteers

Biopharmaceutics and Drug Disposition

Volumn 18, Issue 4, 1997, Pages 325-334

  Robbins, Doris K ^a,b   Hutcheson, Sam J ^a   Miller, Terry D ^a   Green, Victor I ^a   Bhargava, Vijay O ^a   Weir, Scott J ^a  

^a Hoechst Marion Roussel   (United States)

^b SANOFI   (France)

Author keywords

healthy volunteer; MDL 26479; multiple dose; pharmacokinetics; single dose

Indexed keywords

BENZODIAZEPINE RECEPTOR STIMULATING AGENT; PLACEBO; SURITOZOLE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; RANDOMIZED CONTROLLED TRIAL; VOLUNTEER;

ADMINISTRATION, ORAL; ADULT; ANTIDEPRESSIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; MIDDLE AGED; RECEPTORS, GABA-A; REFERENCE VALUES; TRIAZOLES;

EID: 0030947140     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199705)18:4<325::AID-BDD21>3.0.CO;2-1     Document Type: Article

References (5)

1. J. A. Miller, M. W. Dudley, J. H. Kehne, S. M. Sorensen, D. L. Wenstrup and J. M. Kane, MDL 26,479. Drugs Future, 17, 21-23 (1992).
2. J. A. Miller, M. W. Dudley, J. H. Kehne, S. M. Sorensen and J. M. Kane, MDL 26,479: a potential cognition enhancer with benzodiazepine inverse agonist-like properties. Br. J. Pharmacol., 107, 78-86 (1992).
3. A receptor complex. Brain Res., 569, 156-158 (1992).
4. Data on file with Hoechst Marion Roussel, Internal Report, 1991.
5. M. Gibaldi and D. Perrier, Pharmacokinetics, 2nd edn, Dekker, New York, 1982.