Synthesis and antiretroviral evaluation of new alkoxy and aryloxy phosphate derivatives of 3'-azido-3'-deoxythymidine

Journal of Medicinal Chemistry

Volumn 39, Issue 17, 1996, Pages 3418-3422

  Tsotinis, Andrew ^a   Calogeropoulou, Theodora ^b   Koufaki, Maria ^b   Souli, Charikleia ^b   Balzarini, Jan ^c   De Clercq, Erik ^c   Makriyannis, Alexandros ^d  

^a UNIVERSITY OF ATHENS   (Greece)

^b INSTITUTE OF BIOLOGY   (Greece)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ZIDOVUDINE DERIVATIVE;

ARTICLE; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN;

ALKYLATION; ANTIVIRAL AGENTS; CELL LINE; HIV-1; HIV-2; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPIDS; RETROVIRIDAE; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; ZIDOVUDINE;

EID: 0029761595     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950777g     Document Type: Article

References (16)

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16. 50 (50% cytotoxic concentration) is the concentration of compound which causes a 50% reduction in cell viability. The SI (selectivity index) is the ratio of 50% cytotoxic concentration to 50% antivirally effective concentration. For full details, see ref 15.