Cyclic hexapeptides with free carboxylate groups as new receptors for monosaccharides

Organic Letters

Volumn 3, Issue 17, 2001, Pages 2637-2640

  Bitta, Joachim ^a   Kubik, Stefan ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; CARRIER PROTEIN; CELL SURFACE RECEPTOR; CYCLOPEPTIDE; MONOSACCHARIDE; SACCHARIDE BINDING PROTEINS; SACCHARIDE-BINDING PROTEINS;

ARTICLE; CHEMISTRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING;

CARBOXYLIC ACIDS; CARRIER PROTEINS; MONOSACCHARIDES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

EID: 0035940105     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol016158l     Document Type: Article

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23. We determined a 1:1 complex stoichiometry also for other receptor/ monosaccharide combinations, e.g., 2b and β-D-methylglucopyranoside. In addition, the excellent agreement of the saturation curves obtained experimentally in our NMR titrations with the ones calculated on the basis of 1:1 complex formation indicates that this stoichiometry holds for all complexes investigated (see Supporting Information).
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