Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 8, 2001, Pages 969-972

  Foley, Louise H ^a   Palermo, Robert ^a   Dunten, Pete ^a   Wang, Ping ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; PYRIMIDINE 2,4,6 TRIONE DERIVATIVE; STROMELYSIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; SEDATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; HUMANS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; MICE; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035938352     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00104-4     Document Type: Article

References (15)