Differential display reveals downregulation of the phospholipid transfer protein (PLTP) at the mRNA level in brains of patients with Down syndrome

Life Sciences

Volumn 68, Issue 18, 2001, Pages 2169-2179

  Krapfenbauer, K ^a   Yoo, B C ^a   Kim, S H ^a   Cairns, N ^b   Lubec, G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; Cerebellum; Differential Display; Down syndrome; Phospholipid transfer protein

Indexed keywords

MESSENGER RNA; MYELIN; PHOSPHOLIPID TRANSFER PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BIOGENESIS; BRAIN; CELL METABOLISM; CEREBELLUM; CONTROLLED STUDY; DOWN SYNDROME; GENE SEQUENCE; HUMAN; HUMAN TISSUE; MALE; MOLECULAR CLONING; PATHOLOGY; SYNAPTOSOME;

ALZHEIMER DISEASE; BASE SEQUENCE; CARRIER PROTEINS; CEREBELLUM; CLONING, MOLECULAR; DNA PRIMERS; DOWN SYNDROME; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION PROFILING; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PHOSPHOLIPID TRANSFER PROTEINS; PHOSPHOLIPIDS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ALIGNMENT;

EID: 0035937411     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01026-8     Document Type: Article

References (31)

1. Molecular cloning and functional expression of cDNA encoding the pig plasma phospholipid transfer protein
2. Functional expression of human and mouse plasma phospholipid transfer protein: Effect of recombinant and plasma PLTP on HDL subspecies
3. Increased prebeta-high density lipoprotein, apolipoprotein A1 and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein A1 transgenes
4. Transgenic mice expressing human phospholipid transfer protein have increased HDL, non-HDL cholesterol ratio
5. Plasma phospholipid transfer: Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipo-protein (HDL) and enhanced hepatic uptake of phsopholipids and cholesteryl esters from HDL
6. Adenovirus mediated overexpression of human phospholipid transfer protein alters HDL levels in mice
7. Acyl-chain and headgroup specificity of human plasma phospholipid transfer protein
8. Molecular and macromolecular specificity of human plasma phospholipid transfer protein
9. Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein
10. Human plasma phospholipid transfer protein accelerates exchange / transfer of alpha-tocopherol between lipoproteins and cells
11. Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins
12. Complete cDNA encoding human phospholipid transfer protein from human endothelial cells
13. Structure and phospho-lipid transfer activity of human PLTP: Analysis by molecular modeling and site-directed mutagenesis
14. Organization of human phospholipid transfer protein gene
15. Localization of the human phospholipid transfer protein to chromosome 20q12-q13.1
16. Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome
17. Fatty Acid Composition of lipids in cerebral myelin and synaptosomes in phenylketonuria and Down Syndrome
18. Transfer properties of the bovine brain phospholipid transfer protein. Effect of charged phospholipids and of phosphatidylcholine fatty acid composition
19. Transfer properties of the bovine phospholipid transfer protein. Specificity towards phosphatidylcholine analogs and the inhibitory effect of Sphyngomyelin
20. Biochemical studies on myelin isolated from the brains of patients with Down's syndrome
21. Evidence for a membrane defect in Alzheimer disease brain
22. Lipid abnormalities in the brain of adult Down's syndrome and Alzhe-imer's disease
23. Ubiquitin-immunoreactive neuritews in Down's syndrome brains
24. Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down Syndrome and Alzheimer's disease
25. Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization
26. Functional characterization of the promotor region of the human phospho-lipid transfer protein gene
27. Decreased transcription factor junD in brains of patients with Down Syndrome
28. Increased steady state levels of DNA repair genes XRCC1, ERCC2, ERCC3 in brain of patients with Down Syndrome
29. Evidence against the current hypothesis of Gene dosage effects of trisomy 21: Ets2, encoded on chromosome 21 is not overexpressed in hearts of patients with Down Syndrome
30. Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia