Intracellular third loops in AT1 and AT2 receptors determine subtype specificity

Life Sciences

Volumn 69, Issue 5, 2001, Pages 509-516

  Daviet, Laurent ^a,c   Lehtonen, Jukka Y A ^a,d   Hayashida, Wataru ^a,e   Dzau, Victor J ^a   Horiuchi, Masatsugu ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c INSTITUT PASTEUR   (France)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

Angiotensin; Apoptosis; Extracellular signal regulated kinase; Receptor

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INTRACELLULAR THIRD LOOP; PROTEIN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHIMERA; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; MOLECULAR CLONING; NONHUMAN; PROTEIN INTERACTION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; GENE TRANSFER TECHNIQUES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; RECOMBINANT FUSION PROTEINS;

EID: 0035933471     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01144-4     Document Type: Article

References (11)

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7. Identification of a domain in the angiotensin II type 1 receptor determining Gq coupling by the use of receptor chimeras
8. Intracellular third loop domain of angiotensin II type 2 receptor: Role in the cellular signal transduction and functional expression
9. Analysis of functinal domains of angtiotensin II type 2 receptor involved in apoptosis
10. The novel angiotensin II type 2 receptor mediates programmed cell death
11. Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis