T-1032, a novel specific phosphodiesterase type 5 inhibitor, increases venous compliance in anesthetized rats

European Journal of Pharmacology

Volumn 422, Issue 1-3, 2001, Pages 109-114

  Inoue, Hirotaka ^a   Yano, Koji ^a   Ikeo, Tomihiro ^a   Noto, Tsunehisa ^a   Kikkawa, Kohei ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Mean circulatory filling pressure; Phosphodiesterase type 5; Unstressed volume; Vascular compliance

Indexed keywords

2 (4 AMINOPHENYL) 1,2 DIHYDRO 1 OXO 7 (2 PYRIDINYLMETHOXY) 4 (3,4,5 TRIMETHOXYPHENYL) 3 ISOQUINOLINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; GLYCERYL TRINITRATE; MECAMYLAMINE; METHYL 2 (4 AMINOPHENYL) 1,2 DIHYDRO 1 OXO 7 (2 PYRIDINYLMETHOXY) 4 (3,4,5 TRIMETHOXYPHENYL) 3 ISOQUINOLINE CARBOXYLATE SULFATE; NITRIC OXIDE DONOR; NORADRENALIN; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD VOLUME; CAPACITANCE BLOOD VESSEL; CIRCULATION; CONTROLLED STUDY; DRUG EFFECT; DRUG INFUSION; DRUG MECHANISM; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSURE; PRIORITY JOURNAL; RAT; VASODILATATION; VEIN COMPLIANCE;

ANESTHESIA; ANIMALS; BLOOD PRESSURE; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIONIC BLOCKERS; HEART RATE; ISOQUINOLINES; MALE; MECAMYLAMINE; NITROGLYCERIN; NOREPINEPHRINE; PHOSPHODIESTERASE INHIBITORS; PYRIDINES; RATS; RATS, WISTAR; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS; VENOUS PRESSURE;

EID: 0035933429     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01044-5     Document Type: Article

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