Up-regulation of spinal μ-opioid receptor function to activate G-protein by chronic naloxone treatment

Brain Research

Volumn 913, Issue 2, 2001, Pages 170-173

  Narita, Minoru ^a,b   Mizoguchi, Hirokazu ^b   Nagase, Hiroshi ^c   Suzuki, Tsutomu ^a   Tseng, Leon F ^b  

^a HOSHI UNIVERSITY   (Japan)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c TORAY INDUSTRIES INC   (Japan)

Author keywords

Opioid receptor; 35 GTP S binding; G Proteins; Naloxone; Spinal cord; Up regulation

Indexed keywords

ENDOMORPHIN 1; ENDOMORPHIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALOXONE; PROTEIN G; SULFUR 35; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR OCCUPANCY; RECEPTOR UPREGULATION; SPINAL CORD;

ANALGESICS, OPIOID; ANIMALS; BINDING SITES; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MICE; NALOXONE; NARCOTIC ANTAGONISTS; NEURONS; OLIGOPEPTIDES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; SPINAL CORD; SULFUR RADIOISOTOPES; UP-REGULATION;

EID: 0035929507     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02785-8     Document Type: Article

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