Peptide and recombinant antigens for protection against bacterial middle ear infection

Vaccine

Volumn 19, Issue 17-19, 2001, Pages 2323-2328

  Bakaletz, Lauren O ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Adhesin; Chinchilla; Nontypeable Haemophilus influenzae

Indexed keywords

ADHESIN; ANTISERUM; BACTERIAL ANTIGEN; HAEMOPHILUS INFLUENZAE ANTISERUM; HAEMOPHILUS VACCINE; HYBRID PROTEIN; LB1 ANTIGEN; LIPOPROTEIN D LB1 (F) FUSION PROTEIN; PROTEIN P5 FIMBRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; BACTERIUM ISOLATE; CHINCHILLA; CLINICAL FEATURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; EAR PROTECTION; ERADICATION THERAPY; HAEMOPHILUS INFLUENZAE; MORBIDITY; NASOPHARYNX; NONHUMAN; OTITIS MEDIA; PASSIVE IMMUNIZATION; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; CHINCHILLA; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS VACCINES; HUMANS; IMMUNIZATION, PASSIVE; NASOPHARYNX; OTITIS MEDIA; PEPTIDES; RECOMBINANT PROTEINS;

EID: 0035925683     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00522-3     Document Type: Conference Paper

References (19)

1. Frequency of fimbriation of nontypable Haemophilus influenzae and its ability to adhere to chinchilla and human respiratory epithelium
2. Purification and partial characterization of outer membrane proteins P5 and P6 from Haemophilus influenzae type b
3. Molecular cloning and sequence of the gene for outer membrane protein P5 of Haemophilus influenzae
4. Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A
5. Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin
6. Middle ear mucin glycoprotein: Purification and interaction with nontypable Haemophilus influenzae and Moraxella catarrhalis
7. Selective adherence of non-typeable Haemophilus influenzae (NTHi) to mucus or epithelial cells in the chinchilla eustachian tube and middle ear
8. Fimbria-mediated enhanced attachment of nontypeable Haemophilus influenzae to respiratory syncytial virus-infected respiratory epithelial cells
9. Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla
10. Protection against development of otitis media induced by nontypeable Haemophilus influenzae by both active and passive immunization in a chinchilla model of virus-bacterium superinfection
11. Mapping of conformational B cell epitopes within alpha-helical coiled coil proteins
12. Protein D, the glycerophosphodiester phosphodiesterase from Haemophilus influenzae with affinity for human immunoglobulin D, influences virulence in a rat otitis model
13. Immunization with outer membrane protein P6 from nontypeable Haemophilus influenzae induces bactericidal antibody and affords protection in the chinchilla model of otitis media
14. Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media
15. Protection by serum antibodies in experimental nontypable Haemophilus influenzae otitis media
16. Tympanometric configurations and middle ear findings in experimental otitis media
17. Tympanometric evaluation of middle ear function in children with otitis media
18. Nasopharyngeal colonization with nontypeable Haemophilus influenzae in chinchillas
19. Immunological responsiveness of chinchillas to outer membrane and isolated fimbrial proteins of nontypeable Haemophilus influenzae