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0343930698
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For the preparation of the starting amino-protected butyraldehyde, see Supporting Information
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(c) Carretero, J. C.; Gómez Arrayás, R.; Storch de Gracia, I. Tetrahedron Lett. 1996, 37, 3379. For the preparation of the starting amino-protected butyraldehyde, see Supporting Information.
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26
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0041793724
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note
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In all cases similar results were obtained by using methyl iodide or methyl triflate as alkylating agents. A large excess of these reagents (5 or 2 equiv, respectively) was required in order to ensure the complete methylation of the starting amine.
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27
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49549126692
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Trost, B. M.; Arndt, H. C.; Strege, P. E.; Verhoeven, T. R. Tetrahedron Lett. 1976, 3477.
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28
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0042795848
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note
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3).
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