Amino acid substitution(s) in the stem-anchor region of langat virus envelope protein attenuates mouse neurovirulence

Virology

Volumn 286, Issue 1, 2001, Pages 54-61

  Holbrook, Michael R ^a   Ni, Haolin ^a   Shope, Robert E ^a   Barrett, Alan D T ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Attenuation; Langat; Membrane receptor; Stem anchor region

Indexed keywords

MEMBRANE PROTEIN; MEMBRANE RECEPTOR; VIRUS ENVELOPE PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; FLAVIVIRUS; HUMAN; JAPANESE ENCEPHALITIS VIRUS; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR BINDING; STRAIN DIFFERENCE; TICK BORNE DISEASE; VIRION; VIRUS STRAIN; YELLOW FEVER FLAVIVIRUS;

ACARI; JAPANESE ENCEPHALITIS VIRUS; LANGAT VIRUS;

EID: 0035919642     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.0959     Document Type: Article

References (18)

1. Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E
2. Arboviruses
3. Sequence analysis and genetic classification of tick-borne encephalitis virus from Europe and Asia
4. Flavivirus infection enhancement in macrophages: An electron microscopic study of viral cellular entry
5. Characterization of Langat virus antigenic determinants defined by monoclonal antibodies to E, NS1 and preM and identification of a protective, non-neutralizing preM-specific monoclonal antibody
6. The recognition event between virus and host cell receptor: A target for antiviral agents
7. Virus entry into animal cells
8. A live vaccine against tick-borne encephalitis: Integrated studies. I. Basic properties and behavior of the E5 "14" clone (Langat virus)
9. The molecular basis of virulence of the encephalogenic flaviviruses
10. 1 recognition site
11. Flaviviruses
12. Comparison of nucleotide and deduced amino acid sequence of the 5′ non-coding region and structural protein genes of the wild-type Japanese encephalitis virus strain SA12 and its attenuated vaccine derivatives
13. Attenuation of Japanese encephalitis virus by selection of its mouse brain membrane receptor preparation escape variants
14. Interaction of yellow fever virus French neurotropic vaccine strain with monkey brain: Characterization of monkey brain membrane receptor escape variants
15. Chimeric Langat/dengue viruses protect mice from heterologous challenge with the highly virulent strains of tick-borne encephalitis virus
16. Proteolytic activation of tick-borne encephalitis virus by furin
17. Structural requirements for low-pH-induced rearrangements in the envelope glycoprotein of tick-borne encephalitis virus