Characterization of Langat virus antigenic determinants defined by monoclonal antibodies to E, NS1 and preM and identification of a protective, non-neutralizing preM-specific monoclonal antibody

Virus Research

Volumn 43, Issue 2, 1996, Pages 125-136

  Iacono Connors, Lauren C ^a,b   Smith, Jonathan F ^a   Ksiazek, Thomas G ^a,c   Kelley, Cynthia L ^a   Schmaljohn, Connie S ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Hybridomas; Monoclonal antibodies; Tick borne encephalitis

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY; VIRUS ANTIGEN; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; CROSS REACTION; FEMALE; FLAVIVIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TICK BORNE ENCEPHALITIS; VIRUS NEUTRALIZATION;

EID: 0030221144     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-1702(96)01325-1     Document Type: Article

References (40)

1. Arikawa, J., Schmaljohn, A., Schmaljohn, C. and Dalrymple, J. (1989) Characterization of Hantaan virus envelope glycoprotein antigenic determinants by monoclonal antibodies. J. Gen. Virol. 70, 615-624.
2. Bray, M. and Lai, C.-J. (1991) Dengue virus premembrane and membrane proteins elicit a protective immune response. Virology 185, 505-508.
3. Brodeur, B.R., Tsang, P. and Larose, Y. (1984) Parameters affecting ascites tumour formation in mice and monoclonal antibody production. J. Immunol. Methods 71, 265-272.
4. Buckley, A. and Gould, E.A. (1985) Neutralization of yellow fever virus studied using monoclonal and polyclonal antibodies. J. Gen. Virol. 66, 2523-2531.
5. Calisher, C.H., Karabatsos, N., Dalrymple, J.M., Shope, R.E., Porterfield, J.S., Westaway, E.G. and Brandt, W.E. (1989) Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera. J. Gen. Virol. 70, 37-43.
6. Cane, P.A. and Gould, E.A. (1988) Reduction of yellow fever virus mouse neurovirulence by immunization with a bacterially synthesized non-structural protein (NS1) fragment. J. Gen. Virol. 69, 1241-1246.
7. Chambers, T.J., Hahn, C.S., Galler, R. and Rice, C.M. (1990) Flavivirus genome organization, expression, and replication. Annu. Rev. Microbiol. 44, 649-688.
8. Chu, Y.-K., Rossi, C., LeDuc, J., Lee, H., Schmaljohn, C. and Dalrymple, J. (1994) Serological relationships among viruses in the Hantavirus genus, family Bunyaviridae. Virology 198, 196-204.
9. DeMadrid, A.T. and Porterfield, J.S. (1974) The flaviviruses (group B arboviruses): a cross-neutralization study. J. Gen. Virol. 23, 91-96.
10. Falgout, B., Bray, M., Schlesinger, J.J. and Lai, C.J. (1990) Immunization of mice with recombinant vaccinia virus expressing authentic dengue virus nonstructural protein NS1 protects against lethal dengue virus encephalitis. J. Virol. 64, 4356-4363.
11. Fuerst, T.R., Niles, E.G., Studier, F.W. and Moss, B. (1986) Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83, 8122-8126.
12. Gould, E.A., Buckley, A., Barrett, A.D.T. and Cammack, N. (1986) Neutralizing (54K) and non-neutralizing (54K and 48K) monoclonal antibodies against structural and non-structural yellow fever virus proteins confer immunity in mice. J. Gen. Virol. 67, 591-595.
13. Guirakhoo, F., Bolin, R.A. and Roehrig, J.T. (1992) The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoprotein. Virology 191, 921-931.
14. Guirakhoo, F., Heinz, F.X., Mandl, C.W., Holzmann, H. and Kunz, C. (1991) Fusion activity of flaviviruses: comparison of mature and immature (prM-containing) tick-borne encephalitis virions. J. Gen. Virol. 72, 1323-1329.
15. Heinz, F.X., Berger, R., Tuma, W. and Kunz, C. (1983) A topological and functional model of epitopes on the structural glycoprotein of tick-borne encephalitis virus defined by monoclonal antibodies. Virology 126, 525-537.
16. Heinz, F.X. (1986) Epitope mapping of flavivirus glycoproteins. Adv. Virus Res. 31, 103-168.
17. Heinz, F.X., Auer, G., Stiasny, K., Holzmann, H., Mandl, C., Guirakhoo, F. and Kunz, C. (1994a) The interactions of the flavivirus envelope proteins: implications for virus entry and release. Arch. Virol. Suppl. 9, 339-348.
18. Heinz, F.X., Stiasny, K., Puschner-Auer, G., Holzmann, H., Allison, S.L., Mandl, C.W. and Kunz, C. (1994b) Structural changes and functional control of the tick-borne encephalitis virus glycoprotein E by the heterodimeric association with protein prM. Virology 198, 109-117.
19. Henchal, E.A., McCown, J.M., Burke, D.S., Seguin, M.C. and Brandt, W.E. (1985) Epitopic analysis of antigenic determinants on the surface of dengue-2 virions using monoclonal antibodies. Am. J. Trop. Med. Hyg. 34, 162-169.
20. Henchal, E.A., Henchal, L.S. and Schlesinger, J.J. (1988) Synergistic interactions of anti-NS1 monoclonal antibodies protect passively immunized mice from lethal challenge with dengue 2 virus. J. Gen. Virol. 69, 2101-2107.
21. Jacobs, S.C. (1993) A novel recombinant adenovirus vector expressing a flavivirus non-structural protein protects against lethal flavivirus challenge. Clin. Sci. 85, 117-122.
22. Kaufman, B.M., Summers, P.L., Dubois, D.R. and Eckels, K.H. (1987) Monoclonal antibodies against dengue 2 virus E-glycoprotein protect mice against lethal dengue infection. Am. J. Trop. Med. Hyg. 36, 427-434.
23. Kaufman, B.M., Summers, P.L., Dubois, D.R., Cohen, W.H., Gentry, M.K., Timchak, R.L. et al. (1989) Monoclonal antibodies for dengue virus prM glycoprotein protect mice against lethal dengue infection. Am. J. Trop. Med. Hyg. 41, 576-580.
24. Kimura-Kuroda, J. and Yasui, K. (1983) Topographical analysis of antigenic determinants on envelope glycoprotein V3 (E) of Japanese encephalitis virus, using monoclonal antibodies. J. Virol. 45, 124-132.
25. Kimura-Kuroda, J. and Yasui, K. (1988) Protection of mice against Japanese encephalitis virus by passive administration with monoclonal antibodies. J. Immunol. 141, 3606-3610.
26. Konishi, E. and Mason, P.W. (1993) Proper maturation of the Japanese encephalitis virus envelope glycoprotein requires cosynthesis with the premembrane protein. J. Virol. 67, 1672-1675.
27. Konishi, E.S., Pincus, S., Fronseca, B.A.L., Shope, R.E., Paoletti, E. and Mason, P.W. (1991) Comparison of protective immunity elicited by recombinant vaccinia viruses that synthesize E or NS1 of Japanese encephalitis virus. Virology 185, 401-410.
28. Mandl, C.W., Iacono-Connors, L., Wallner, G., Holzmann, H., Kunz, C. and Heinz, F.X. (1991) Sequence of the genes encoding the structural proteins of the low-virulence tickborne flaviviruses Langat TP21 and Yelantsev. Virology 185, 891-895.
29. Mason, P.W., Dalrymple, J.M., Gentry, M.K., McCown, J.M., Hoke, C.H., Burke, D.S. et al. (1989) Molecular characterization of a neutralizing domain of the Japanese encephalitis virus structural glycoprotein. J. Gen. Virol. 70, 2037-2049.
30. Mathews, J.H. and Roehrig, J.T. (1984) Elucidation of the topography and determination of the protective epitopes on the E glycoprotein of Saint Louis encephalitis virus by passive transfer with monoclonal antibodies. J. Immunol. 132, 1533-1537.
31. Monath, T.P. (1990) Flaviviruses. In: B.N. Fields and D.M. Knipe (Eds.), Virology. Raven Press, New York, pp. 763-814.
32. Moss, B., Elroy-Stein, O., Mizukami, T., Alexander, W.A. and Fuerst, T. (1990) New mammalian expression vectors, (product review). Nature 349, 91.
33. Pifat, D.Y., Osterling, M.C. and Smith, J.F. (1988) Antigenic analysis of Punta Toro virus and identification of protective determinants with monoclonal antibodies. Virology 167, 442-450.
34. Schlesinger, J.J., Brandriss, M.W. and Walsh, E.E. (1985) Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48. J. Immunol. 135, 2805-2809.
35. Schlesinger, J.J., Brandriss, M.W., Cropp, C.B. and Monath, T.P. (1986) Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1. J. Virol. 60, 1153-1155.
36. Schlesinger, J.J., Brandriss, M.W. and Walsh, E.E. (1987) Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1. J. Gen. Virol. 68, 853-857.
37. Westaway, E.G., Brinton, M.A., Gaidamovich, S., Horzinek, M.C., Igarashi, A., Kaariainen, L. et al. (1985) Flaviviridae. Intervirology 24, 183-192.
38. Wengler, G., Wengler, G., Nowak, T. and Wahn, K. (1987) Analysis of influence of proteolytic cleavage on the structural organization of the surface of the West Nile flavivirus leads to the isolation of a protease resistant E protein oligomer from the viral surface. Virology 160, 210-219.
39. Wengler, G., Bradley, D.W., Collett, M.S., Heinz, F.X., Schlesinger, R.W. and H., S.J. (1995) Flaviviridae. In: F.A. Murphy, C.M. Fauquet, D.H.L. Bishop, S.A. Chabrial, A.W. Jarvis, G.P. Martelli, M.A. Mayo and M.D. Summers (Eds.), Virus Taxonomy: Sixth Report of the International Committee on Taxonomy of Viruses. Springer-Verlag, New York, pp. 415-427.
40. Wengler, G. and Wengler, G. (1989) Cell-associated West Nile flavivirus is covered with E + pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release. J. Virol. 63, 2521-2526.