The human IgG3 hinge mediates the formation of antigen dimers that enhance humoral immune responses to DNA immunisation

Vaccine

Volumn 19, Issue 30, 2001, Pages 4115-4120

  Drew, Damien R ^a   Boyle, Jefferey S ^a,b   Lew, Andrew M ^a,b   Lightowlers, Marshall W ^b   Strugnell, Richard A ^b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

45W; Antigen dimerisation; DNA vaccine; Taenia ovis

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B ANTIBODY; IMMUNOGLOBULIN G3; PLASMID DNA; PROTEIN 45W; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DIMERIZATION; EXON; FEMALE; GENETIC TRANSFECTION; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TAENIA OVIS; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; COS CELLS; DIMERIZATION; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, HELPER-INDUCER; TAENIA; VACCINES, DNA; VACCINES, SYNTHETIC;

EID: 0035919540     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00182-7     Document Type: Article

References (19)

1. Influence of cellular location of expressed antigen on the efficacy of DNA vaccination: Cytotoxic T lymphocyte and antibody responses are suboptimal when antigen is cytoplasmic after intramuscular DNA immunization
2. Humoral immune responses to DNA vaccines expressing secreted, membrane bound and non-secreted forms of the Taenia ovis 45W antigen
3. DNA-based immunization by in vivo transfection of dendritic cells
4. Priming of cytotoxic T lymphocytes by DNA vaccines: Requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes
5. Site-directed immune responses in DNA vaccines encoding ligand-antigen fusions
6. Immunoglobulin G: Functional sites
7. Primary structure of the 'hinge' region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit
8. Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: Comparison with the other human C gamma genes
9. Flexibility of human IgG subclasses
10. Vaccination against ovine cysticercosis using a defined recombinant antigen
11. Taenia ovis recombinant vaccine -'Quo vadit'
12. Parasite vaccine development: Large-scale recovery of immunogenic Taenia ovis fusion protein GST-45W(B/X) from Escherichia coli inclusion bodies
13. Host-protective fragments and antibody binding epitopes of the Taenia ovis 45W recombinant antigen
14. Immune responses associated with protection in sheep vaccinated with a recombinant antigen from Taenia ovis
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Vaccination with plasmid DNA expressing antigen from genomic or cDNA gene forms induces equivalent humoral immune responses
17. Biological features of genetic immunization
18. Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigen peptide system
19. Analysis of antigenicity and immunogenicity of five different chemically defined constructs of a peptide