Endogenous CRX expression and IRBP promoter activity in retinoblastoma cells

Brain Research

Volumn 916, Issue 1-2, 2001, Pages 136-142

  Boatright, Jeffrey H ^a,c   Borst, Diane E ^b   Stodulkova, Eva ^a   Nickerson, John M ^a  

^a EMORY EYE CENTER   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antisene; CRX; IRBP; Quantitative PCR; Retinoblastoma

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; OLIGONUCLEOTIDE; PROTEIN CRX; TRANS ACTING FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TARGETING; RETINOBLASTOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMIAN VIRUS 40;

BASE SEQUENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; EYE PROTEINS; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC VECTORS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; OTX TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); RETINA; RETINOBLASTOMA; RETINOL-BINDING PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASE H, CALF THYMUS; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035914210     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02884-0     Document Type: Article

References (23)

1. A major cis activator of the IRBP gene contains CRX-binding and Ret-1/PCE-I elements
2. The 5′ flanking regions of mouse IRBP and arrestin have promoter activity in primary embryonic chicken retina cell cultures
3. A region of the IRBP 5′ flanking sequence is needed to restrict promoter activity to photoreceptor cells
4. OTX2 homeodomain protein binds a DNA element necessary for interphotoreceptor retinoid binding protein gene expression
5. A single cis-acting element in a short promoter segment of the gene encoding the interphotoreceptor retinoid-binding protein confers tissue-specific expression
6. Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina
7. Promotion of the release of 11-cis-retinal from cultured retinal pigment epithelium by interphotoreceptor retinoid-binding protein
8. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
9. Molecular mechanisms of action of antisense drugs
10. Functional dissection of the promoter of the interphotoreceptor retinoid-binding protein gene: The cone-rod-homeobox element is essential for photoreceptor-specific expression in vivo
11. Elements regulating the transcription of human interstitial retinoid-binding protein (IRBP) gene in cultured retinoblastoma cells
12. Crx, a novel otx-like homeobox gene, shows photoreceptor-specific expression and regulates photoreceptor differentiation
13. Retinopathy and attenuated circadian entrainment in Crx-deficient mice
14. Antisense gene inhibition by C-5-substituted deoxyuridine-containing oligodeoxynucleotides
15. Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression
16. Retina-specific expression from the IRBP promoter in transgenic mice is conferred by 212 bp of the 5′-flanking region
17. Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx
18. Interphotoreceptor retinoid-binding protein: Role in the delivery of retinol to the pigment epithelium
19. Interphotoreceptor retinoid-binding protein promotes rhodopsin regeneration in toad photoreceptors
20. Detection of interphotoreceptor retinoid binding protein (IRBP) mRNA in human and cone-dominant squirrel retinas by in situ hybridization
21. Retinal photoreceptor neurons and pinealocytes accumulate mRNA for interphotoreceptor retinoid-binding protein (IRBP)
22. Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines
23. Immunochemical distribution of interphotoreceptor retinoid-binding protein in selected species