The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments

Journal of Cell Biology

Volumn 152, Issue 6, 2001, Pages 1313-1319

  Ono, Shoichiro ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Actin filament dynamics; ADF cofilin; AIP1; Myofibrils; WD repeats

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; ALPHA ACTIN; COFILIN; GENE PRODUCT; PHALLOIDIN; PROTEIN UNC 78; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ARTICLE; CAENORHABDITIS ELEGANS; CYTOSKELETON; GENE DELETION; IMMUNOFLUORESCENCE MICROSCOPY; MUSCLE FIBRIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; POINT MUTATION; PRIORITY JOURNAL;

ACTINS; AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENES, HELMINTH; HELMINTH PROTEINS; MICROFILAMENT PROTEINS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MOVEMENT; MUTATION; MYOFIBRILS; PHYLOGENY; SEQUENCE ALIGNMENT;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA;

EID: 0035911962     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.152.6.1313     Document Type: Article

References (40)

1. A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein
2. Hyperosmotic stress-induced reorganization of actin bundles in Dictyostelium cells over-expressing cofilin
3. Defining protein interactions with yeast actin in vivo
4. Proteins of the ADF/cofilin family: Essential regulators of actin dynamics
5. Distribution and cellular localization of actin depolymerizing factor
6. The genetics of Caenorhabditis elegans
7. Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: Implication in actin-based motility
8. Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion
9. Moving and stationary actin filaments are involved in spreading of postmitotic PtK2 cells
10. Temperature-sensitive mutation affecting myofilament assembly in Caenorhabditis elegans
11. Myosin and paramyosin of Caenorhabditis elegans embryos assemble into nascent structures distinct from thick filaments and multi-filament assemblages
12. The unc-86 gene product couples cell lineage and cell identity in C. elegans
13. Flying through the Drosophila cytoskeletal genome
14. Assembly of body wall muscle and muscle cell attachment structures in Caenorhabditis elegans
15. Cooperation of two actin-binding proteins, cofilin and Aip1, in Saccharomyces cerevisiae
16. DAip1, a Dictyostelium homologue of the yeast actin-interacting protein 1, is involved in endocytosis, cytokinesis, and motility
17. Cofilin promotes rapid actin filament turnover in vivo
18. Essential functions and actin-binding surfaces of yeast cofilin revealed by systematic mutagenesis
19. Defining actin filament length in striated muscle: Rulers and caps or dynamic stability?
20. Characterization of actin filament severing by actophorin from Acanthamoeba castellanii
21. A novel 66-kDa stress protein, p66, associated with the process of cyst formation of Physarum polycephalum is a Physarum homologue of a yeast actin-interacting protein, AIP1
22. ADF/cofilin weakens lateral contacts in the actin filament
23. Cofilin changes the twist of F-actin: Implications for actin filament dynamics and cellular function
24. Muscle: Structure, function, and development
25. Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix
26. The fax-1 nuclear hormone receptor regulates axon pathfinding and neurotransmitter expression
27. Quantitative analysis of low molecular weight G-actin-binding proteins, cofilin, ADF and profilin, expressed in developing and degenerating chicken skeletal muscles
28. XAIP1: A Xenopus homologue of yeast actin interacting protein 1 (AIP1), which induces disassembly of actin filaments cooperatively with ADF/cofilin family proteins
29. Two Caenorhabditis elegans actin depolymerizing factor/cofilin proteins, encoded by the unc-60 gene, differentially regulate actin filament dynamics
30. Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle
31. UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle
32. The C-terminal tail of UNC-60B (ADF/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site
33. Uncoupling actin filament fragmentation by cofilin from increased subunit turnover
34. Aip1p interacts with cofilin to disassemble actin filaments
35. The WD repeat: A common architecture for diverse functions
36. Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia
37. Muscle
38. Mutants with altered muscle structure of Caenorhabditis elegans
39. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans
40. Identification of genetic elements associated with muscle structure in the nematode Caenorhabditis elegans