Therapeutic efficacy of liposomal gentamicin in clinically relevant rat models

International Journal of Pharmaceutics

Volumn 214, Issue 1-2, 2001, Pages 103-105

  Schiffelers, Raymond M ^a,b   Storm, Gert ^b   Bakker Woudenberg, Irma A J M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Bacterial susceptibility; Drug targeting; Immunocompromised; Infection; Sterically stabilized liposomes

Indexed keywords

LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG STABILITY; DRUG TARGETING; ENCAPSULATION; HOST RESISTANCE; INOCULATION; KLEBSIELLA PNEUMONIAE; LEUKOPENIA; LOBAR PNEUMONIA; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY; SURVIVAL RATE;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG CARRIERS; GENTAMICINS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LIPOSOMES; PNEUMONIA, BACTERIAL; RATS;

EID: 0035910872     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00643-8     Document Type: Conference Paper

References (8)

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2. Efficacy of gentamicin or ceftazidime entrapped in liposomes with prolonged blood circulation and enhanced localization in Klebsiella pneumoniae-infected lung tissue
3. Antibiotic resistance: A current perspective
4. The lung in the immunocompromised patient. Infectious complications Part 1
5. Pharmacodynamic principles of antimicrobial therapy in the prevention of resistance
6. Concepts on the use of liposomal antimicrobial agents: Applications for aminoglycosides
7. Defense mechanisms against infections
8. Localization of sterically stabilized liposomes in experimental rat Klebsiella pneumoniae pheumonicai dependence on circulation kinetics and presence of the poly(ethylene) glycol coating