Convenient efficient synthesis of TAK-779, a nonpeptide CCR5 antagonist: Development of preparation of various ammonium salts using trialkylphosphite and N-halogenosuccinimide

Tetrahedron

Volumn 57, Issue 8, 2001, Pages 1525-1529

  Ikemoto, Tomomi ^a   Nishiguchi, Atsuko ^a   Mitsudera, Hiroyuki ^a   Wakimasu, Mitsuhiro ^a   Tomimatsu, Kiminori ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Alkylation; N halogenosuccinimide; TAK 779; Trialkylphosphite

Indexed keywords

AMMONIUM CHLORIDE; AMMONIUM DERIVATIVE; CHEMOKINE RECEPTOR CCR5; HYDROCHLORIC ACID; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; PHOSPHITE; SUCCINIMIDE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; METHYLATION; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 0035906010     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(00)01093-0     Document Type: Article

References (32)