Subtilisin-like autotransporter serves as maturation protease in a bacterial secretion pathway

EMBO Journal

Volumn 20, Issue 18, 2001, Pages 5040-5048

  Coutte, Loic ^a   Antoine, Rudy ^a   Drobecq, Hervé ^b   Locht, Camille ^a   Jacob Dubuisson, Françoise ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b INSTITUT DE BIOLOGIE DE LILLE   (France)

Author keywords

Autotransporter protein; Filamentous haemagglutinin; Precursor maturation; Protein secretion; Subtilisin like protein

Indexed keywords

HEMAGGLUTININ; PROTEIN; PROTEINASE; SPHB1 PROTEASE; SUBTILISIN; SUBTILISIN LIKE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BORDETELLA PERTUSSIS; CELL MEMBRANE; EXTRACELLULAR SPACE; GRAM NEGATIVE BACTERIUM; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECRETION; PROTEIN SYNTHESIS;

ADHESINS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BASE SEQUENCE; BORDETELLA PERTUSSIS; CARRIER PROTEINS; HEMAGGLUTININS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SERINE ENDOPEPTIDASES; SUBTILISIN; VIRULENCE FACTORS, BORDETELLA;

EID: 0035903666     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.18.5040     Document Type: Article

References (48)

1. Understanding signal transduction during bacterial infection
2. New virulence-activated and virulence-repressed genes identified by systematic gene inactivation and generation of transcriptional fusions in Bordetella pertussis
3. Subtilase-like pro-protein convertases: From molecular specificity to therapeutic applications
4. Molecular cloning and characterization of protective outer membrane protein P69 from Bordetella pertussis
5. Type IV secretion: Intercellular transfer of macromolecules by systems ancestrally related to conjugation machines
6. Genetic characterization of Bordetella pertussis filamentous hemagglutinin: A protein processed from an unusually large precursor
7. ABC transporters: Bacterial exporters
8. Cloning and sequencing of a Bordetella pertussis serum resistance locus
9. Tracheal colonization factor: A Bordetella pertussis secreted virulence determinant
10. A C-terminal domain conserved in precursor processing proteases is required for intramolecular N-terminal maturation of pro-Kex2 protease
11. Maturation and secretion of the non-typable Haemophilus influenzae HMW1 adhesin: Roles of the N-terminal and C-terminal domains
12. Evidence that a folded conformation is not compatible with FhaC-mediated secretion of the Bordetella pertussis filamentous hemagglutinin
13. Novel topological features for FhaC, the outer membrane transporter involved in the secretion of Bordetella pertussis filamentous hemagglutinin
14. Virulence functions of autotransporter proteins
15. The great escape: Structure and function of the autotransporter proteins
16. Lack of functional complementation between Bordetella pertussis filamentous hemagglutinin and Proteus mirabilis HpmA hemolysin secretion machineries
17. Channel formation by FhaC, the outer membrane protein involved in the secretion of the Bordetella pertussis filamentous hemagglutinin
18. Two-partner secretion in Gram-negative bacteria: A thrifty, specific pathway for large virulence proteins
19. The ABC-exporter genes involved in the lipase secretion are clustered with the genes for lipase, alkaline protease and serine protease homologues in Pseudomonas fluorescens no. 33
20. N-terminal characterization of the Bordetella pertussis filamentous hemagglutinin
21. Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells
22. Immunodominant domains present on the Bordetella pertussis vaccine component filamentous hemagglutinin
23. Molecular studies of Ssal, a serotype-specific antigen of Pasteurella haemolytica
24. Common accessory genes for the Bordetella pertussis filamentous hemagglutinin and fimbriae share sequence similarities with the papC and papD gene families
25. The filamentous hemagglutinin, a multifaceted adhesion produced by virulent Bordetella spp.
26. Bordetella pertussis, molecular pathogenesis under multiple aspects
27. The pIC plasmid and phage vectors with versatile cloning sites for recombinant selection by insertional inactivation
28. Interaction of the Bordetella pertussis filamentous hemagglutinin with heparin
29. Heparin-inhibitable lectin activity of the filamentous hemagglutinin adhesin of Bordetella pertussis
30. Characterization of the precursor of Serratia marcescens serine protease and COOH-terminal processing of the precursor during its excretion through the outer membrane of Escherichia coli
31. Furin: A mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins
32. Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250
33. Two genes encoding serine protease homologues in Serratia marcescens and characterization of their products in Escherichia coli
34. Type III export: New uses for an old pathway
35. Gene structure and extracellular secretion of Neisseria gonorrheae IgA protease
36. The complete general secretory pathway in Gram-negative bacteria
37. Versatile suicide vectors which allow direct selection for gene replacement in Gram-negative bacteria
38. Distinct roles of the N-terminal and the C-terminal precursor domains in the biogenesis of the Bordetella pertussis filamentous hemagglutinin
39. Biology of type II secretion
40. Lipid modification of bacterial prolipoprotein
41. Monoclonal antibody against pertussis toxin: Effect on toxin activity and pertussis infections
42. Detection of large COOH-terminal domains processed from the precursor of Serratia marcescens serine protease in the outer membrane of Escherichia coli
43. Characterization of secretory intermediates of Serratia marcescens serine protease produced during its extracellular secretion from Escherichia coli cells
44. Subtilases: The superfamily of subtilisin-like serine proteases
45. A broad host range mobilization system for in vivo genetic engineering: Transposon mutagenesis in Gram-negative bacteria
46. Use of conditionally counterselectable suicide vectors for allelic exchange
47. Characterization of the Lactococcus lactis Nisin A operon genes nisP, encoding a subtilisin-like serine protease involved in precursor processing and nisR, encoding a regulatory protein involved in nisin biosynthesis
48. Haemophilus ducreyi secretes a filamentous hemagglutinin-like protein