Solid Phase Synthesis of Carbocyclic L-2′-Deoxynucleosides

Organic Letters

Volumn 3, Issue 10, 2001, Pages 1471-1473

  Choo, Hyunah ^a   Chong, Youhoon ^a   Chu, Chung K ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; DRUG DERIVATIVE; FUSED HETEROCYCLIC RINGS; NEODYSIHERBAINE A; NUCLEOSIDE; SOLVENT;

ARTICLE; COMBINATORIAL CHEMISTRY; COMPARATIVE STUDY; ISOLATION AND PURIFICATION; METHODOLOGY; SYNTHESIS;

ALANINE; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; COMBINATORIAL CHEMISTRY TECHNIQUES; NUCLEOSIDES; SOLVENTS;

EID: 0035902223     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol015783n     Document Type: Article

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16. 3 (10 equiv) at room temperature for 24 h. The reaction mixture was filtered through a short silica gel pad. The filtrate was concentrated and purified by column chromatography on silica gel.
17. All carbocyclic nucleosides from solid phase synthesis were analyzed by HPLC and/or MS and compared with those from solution phase synthesis.
18. The scheme for the solution phase synthesis is as shown below: (Matrix presented)
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