Expression of the gene encoding the β-amyloid precursor protein APP in Xenopus laevis

Molecular Brain Research

Volumn 97, Issue 1, 2001, Pages 13-20

  Van Den Hurk, Wilhelmina H ^a   Bloemen, Marjon ^a   Martens, Gerard J M ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

Amyloid; Alzheimer's disease; Amyloid precursor protein; Xenopus leavis

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ISOPROTEIN; MESSENGER RNA; PEPTIDE;

ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BRAIN; CONTROLLED STUDY; DNA LIBRARY; GENE DUPLICATION; GENE EXPRESSION; GENE FUNCTION; GENE STRUCTURE; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN VARIANT; RAT; SPECIES DIFFERENCE; TISSUE DISTRIBUTION; XENOPUS LAEVIS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BASE SEQUENCE; CATTLE; DNA, COMPLEMENTARY; DOGS; EVOLUTION, MOLECULAR; GENE DUPLICATION; GENE EXPRESSION PROFILING; GENE LIBRARY; GENES; GUINEA PIGS; HUMANS; MAMMALS; MICE; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PITUITARY GLAND, POSTERIOR; PROTEIN ISOFORMS; RABBITS; RATS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SHEEP; SWINE; URSIDAE; XENOPUS LAEVIS;

ANURA; MAMMALIA; XENOPUS LAEVIS;

EID: 0035900885     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00279-0     Document Type: Article

References (57)

1. Localization of amyloid-β protein messenger RNA in brains from patients with Alzheimer's disease
2. Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice
3. Albumin phylogeny for clawed frogs
4. Structure and expression of Xenopus prohormone convertase PC2
5. NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor
6. What the evolution of the amyloid protein precursor supergene family tells us about its function
7. Apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor
8. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence
9. Study of the synthesis and secretion of normal and arificial mutants of murine amyloid precursor protein (APP): Cleavage of APP occurs in a late compartment of the default secretion pathway
10. Amyloidogenicity of rodent and human βA4 sequences
11. Cleavage of amyloid-β peptide during constitutive processing of its precursor
12. Potentially amyloidogenic carboxy-terminal derivatives of the amyloid protein precursor
13. Expression of the amyloid precursor protein gene in mouse oocytes and embryos
14. Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: Modulation by interleukin-1
15. Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein
16. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
17. Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease
18. Beta-amyloid protein is modified with O-linked N-acetylglucosamine
19. Beta-amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms
20. Inhibition of β-amyloid formation identifies proteolytic precursors and subcellular site of catabolism
21. The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment
22. Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis
23. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-1
24. Amyloid β-protein precursor (APP) of cultured cells: Secretory and non-secretory forms of APP
25. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
26. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
27. Differential induction of two p24δ putative cargo receptors upon activation of a prohormone-producing cell
28. Characterization of sorting signals in the β-amyloid precursor protein cytoplasmic domain
29. Expression of two proopiomelancortin genes in the pituitary gland of Xenopus laevis: Complete structure of the two preprohormones
30. 2 dopamine receptor
31. Polymorphism and absence of Leuenkephalin sequences in proenkephalin genes in Xenopus laevis
32. Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives
33. 0
34. A Xenopus homologue of the human β-amyloid precursor protein: Developmental regulation of its gene expression
35. Developmental regulation of Xenopus β-amyloid precursor protein gene expression
36. Deletion of an endosomal/lysosomal targeting signal promotes the secretion of Alzheimer's disease amyloid precursor protein (APP)
37. Soluble derivatives of the β-amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β-amyloid protein
38. A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor
39. Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons
40. Amyloid β-protein precursor is possibly a heparan sulfate proteoglycan core protein
41. Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease
42. Alzheimer's disease amyloidogenic glycoprotein: Expression pattern in rat brain suggests a role in cell contact
43. Molecular cloning of the cDNA for a human amyloid precursor protein homolog: Evidence for a multigene family
44. Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C
45. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein
46. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
47. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
48. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway
49. Signal-dependent membrane protein trafficking in the endocytic pathway
50. Ectodomain phosphorylation of β-amyloid precursor protein at two distinct cellular locations
51. Secretion of the β/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells
52. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor
53. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor
54. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid peptide
55. Xenopus laevis serum albumins are encoded in two closely related genes
56. Prolines and amyloidogenicity in fragments of the Alzheimer's peptide β/A4
57. Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle