Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: A progenitor of mammalian adenylyl cyclases

EMBO Journal

Volumn 20, Issue 14, 2001, Pages 3667-3675

  Ying Lan Guo, ^a   Seebacher, T ^a   Kurz, U ^a   Linder, J U ^a   Schultz, J E ^a  

^a Pharmazeutisches Institut   (Germany)

Author keywords

Adenylyl cyclases; Bacterial eukaryotic expression; Catalysis; Evolution; Mycobacterium tuberculosis

Indexed keywords

ADENYLATE CYCLASE; DIMER;

ARTICLE; BACTERIAL GENE; ENZYME ANALYSIS; ESCHERICHIA COLI; GENE TRANSFER; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL LINE; DIMERIZATION; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035898614     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.14.3667     Document Type: Article

References (33)

1. Our genome unveiled
2. Characterization and metabolism of cyclic guanosine 3′5′monophosphate in Mycobacterium smegmatis
3. Structure of the MscL homolog from Mycobacterium tuberculosis: A gated mechanosensitive ion channel
4. Functional characterization of a potassium-selective prokaryotic glutamate receptor
5. A region of adenylyl cyclase 2 critical for regulation by G protein βγ subunits
6. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
7. Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3 Å resolution
8. Hydrodynamic properties of the β-adrenergic receptor and adenylate cyclase from wild type and variant S49 lymphoma cells
9. CyaG. A novel cyanobacterial adenylyl cyclase and a possible ancestor of mammalian guanylyl cyclases
10. Calcium phosphate transfection
11. Adenylyl cyclase amino acid sequence: Possible channel- or transporter-like structure
12. Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium
13. Catalytic mechanism of the adenylyl and guanylyl cyclases: Modeling and mutational analysis
14. Tubercle bacilli in infected macrophages may inhibit phagosome-lysosome fusion by causing increased cAMP concentrations
15. Functional classification of cNMP-binding proteins and nucleotide cyclases with implications for novel regulatory pathways in Mycobacterium tuberculosis
16. Modeling the impact of global tuberculosis control strategies
17. Lack of adenosine-3′, 5′monophosphate receptor protein and apparent lack of expression of adenosine 3′, 5′-monophosphate functions in Mycobacterium smegmatis CDC 46
18. The structure of adenylate cyclase systems
19. A highly sensitive adenylate cyclase assay
20. Mammalian heterotrimeric G-protein-like proteins in mycobacteria: Implications for cell signalling and survival in eukaryotic host cells
21. Complexity and diversity of mammalian adenylyl cyclases
22. Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases
23. Construction of a soluble adenylyl cyclase activated by Gsα and forskolin
24. Catalytic mechanism and regulation of mammalian adenylyl cyclases
25. Truncation and alanine-scanning mutants of type I adenylyl cyclase
26. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα-GTPγS
27. Two-metal-ion catalysis in adenylyl cyclase
28. Interaction of the two cytosolic domains of mammalian adenylyl cyclase
29. Two cytoplasmic domains of mammalian adenylyl cyclase form a Gsα- and forskolin-activated enzyme in vitro
30. The conserved asparagine and arginine are essential for catalysis of mammalian adenylyl cyclase
31. Purification of the calmodulin-sensitive adenylate cyclase from bovine cerebral cortex
32. Structure of the adenylyl cyclase catalytic core