-
1
-
-
0017186325
-
Metabolism of dihalomethanes to formaldehyde and inorganic halide. I. In vitro studies
-
Ahmed, A. E., and Anders, M. W., 1976, Metabolism of dihalomethanes to formaldehyde and inorganic halide. I. In vitro studies. Drug Metab. Dispos. 4:357-361.
-
(1976)
Drug Metab. Dispos.
, vol.4
, pp. 357-361
-
-
Ahmed, A.E.1
Anders, M.W.2
-
2
-
-
0018176867
-
Metabolism of dihalomethanes to formaldehyde and inorganic halide. II. Studies on the mechanism of the reaction
-
Ahmed, A. E., and Anders, M. W., 1978, Metabolism of dihalomethanes to formaldehyde and inorganic halide. II. Studies on the mechanism of the reaction. Biochem. Pharmacol. 27:2021-2025.
-
(1978)
Biochem. Pharmacol.
, vol.27
, pp. 2021-2025
-
-
Ahmed, A.E.1
Anders, M.W.2
-
3
-
-
0023923003
-
Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites
-
Anders, M. W., Lash, L. H., Dekant, W., Elfarra, A. A., and Dohn, D. R., 1988, Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. CRC Crit. Rev. Toxicol. 18:311-342.
-
(1988)
CRC Crit. Rev. Toxicol.
, vol.18
, pp. 311-342
-
-
Anders, M.W.1
Lash, L.H.2
Dekant, W.3
Elfarra, A.A.4
Dohn, D.R.5
-
4
-
-
0001869934
-
Glutathione-dependent bioactivation of xenobiotics
-
Anders, M. W., 1991, Glutathione-dependent bioactivation of xenobiotics. FASEB J. 4:87-92.
-
(1991)
FASEB J.
, vol.4
, pp. 87-92
-
-
Anders, M.W.1
-
5
-
-
0025981543
-
Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans
-
Andersen, M. E., Clewell, H. J. I., Gargas, M. L., MacNaughton, M. G., Reitz, R. H., Nolan, R. J., and McKenna, M. J., 1991, Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humans. Toxicol. Appl. Pharmacol. 108:14-27.
-
(1991)
Toxicol. Appl. Pharmacol.
, vol.108
, pp. 14-27
-
-
Andersen, M.E.1
Clewell, H.J.I.2
Gargas, M.L.3
MacNaughton, M.G.4
Reitz, R.H.5
Nolan, R.J.6
McKenna, M.J.7
-
6
-
-
0027267051
-
Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: Implications for the risk of trichloroethene exposure
-
Birner, G., Vamvakas, S., Dekant, W., and Henschler, D., 1993, Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: Implications for the risk of trichloroethene exposure. Environ. Health Perspect. 99:281-284.
-
(1993)
Environ. Health Perspect.
, vol.99
, pp. 281-284
-
-
Birner, G.1
Vamvakas, S.2
Dekant, W.3
Henschler, D.4
-
7
-
-
9344256422
-
Bioactivation of dichloromethane: The role of toxic glutathione conjugates in mutagenicity
-
Blumbach, S., Hashmi, M., Anders, M. W., and Dekant, W., 1993, Bioactivation of dichloromethane: The role of toxic glutathione conjugates in mutagenicity. ISSX Proceedings 4:150.
-
(1993)
ISSX Proceedings
, vol.4
, pp. 150
-
-
Blumbach, S.1
Hashmi, M.2
Anders, M.W.3
Dekant, W.4
-
8
-
-
0014458353
-
Role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis
-
Boyland, E., and Chasseaud, L. F., 1969, Role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis. Adv. Enzymol. 32:173.
-
(1969)
Adv. Enzymol.
, vol.32
, pp. 173
-
-
Boyland, E.1
Chasseaud, L.F.2
-
9
-
-
0021964203
-
Prooxidant states and tumor promotion
-
Cerutti, P. A., 1985, Prooxidant states and tumor promotion. Science 227:375-381.
-
(1985)
Science
, vol.227
, pp. 375-381
-
-
Cerutti, P.A.1
-
10
-
-
0025268190
-
Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes
-
Cmarik, J. L., Inskeep, P. B., Meredith, M. J., Meyer, D. J., Ketterer, B., and Guengerich, F. P., 1990, Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes. Cancer Res. 50:2747-2752.
-
(1990)
Cancer Res.
, vol.50
, pp. 2747-2752
-
-
Cmarik, J.L.1
Inskeep, P.B.2
Meredith, M.J.3
Meyer, D.J.4
Ketterer, B.5
Guengerich, F.P.6
-
11
-
-
0026657542
-
Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione
-
Cmarik, J. L., Humphreys, W. G., Bruner, K. L., Lloyd, R. S., Tibbetts, C., and Guengerich, F. P., 1992, Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. J. Biol. Chem. 267:6672-6679.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 6672-6679
-
-
Cmarik, J.L.1
Humphreys, W.G.2
Bruner, K.L.3
Lloyd, R.S.4
Tibbetts, C.5
Guengerich, F.P.6
-
12
-
-
0023544718
-
Nephrotoxicity and hepatotoxicity of 1,1-dichloro-2,2-difluoroethylene in the rat
-
Commandeur, J. N. M., Oostendorp, R. A. J., Schoofs, P. R., Xu, B., and Vermeulen, N. P. E., 1987, Nephrotoxicity and hepatotoxicity of 1,1-dichloro-2,2-difluoroethylene in the rat. Biochem. Pharmacol. 36:4229-4237.
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 4229-4237
-
-
Commandeur, J.N.M.1
Oostendorp, R.A.J.2
Schoofs, P.R.3
Xu, B.4
Vermeulen, N.P.E.5
-
13
-
-
0025734238
-
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene
-
Commandeur, J. N. M., Boogard, P. J., Mulder, G. J., and Vermeulen, N. P. E., 1991, Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene. Arch. Toxicol. 65:373-380.
-
(1991)
Arch. Toxicol.
, vol.65
, pp. 373-380
-
-
Commandeur, J.N.M.1
Boogard, P.J.2
Mulder, G.J.3
Vermeulen, N.P.E.4
-
14
-
-
0018569021
-
The nephrotoxicity of p-aminophenol. I. The effect on microsomal cytochromes, glutathione and covalent binding in kidney and liver
-
Crowe, C. A., Yong, A. C., Calder, I. C., Ham, K. N., and Tange, J. D., 1979, The nephrotoxicity of p-aminophenol. I. The effect on microsomal cytochromes, glutathione and covalent binding in kidney and liver. Chem.-Biol. Interact. 27:235-243.
-
(1979)
Chem.-Biol. Interact.
, vol.27
, pp. 235-243
-
-
Crowe, C.A.1
Yong, A.C.2
Calder, I.C.3
Ham, K.N.4
Tange, J.D.5
-
15
-
-
0021263456
-
Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans
-
Dekant, W., Metzler, M., and Henschler, D., 1984, Novel metabolites of trichloroethylene through dechlorination reactions in rats, mice and humans. Biochem. Pharmacol. 33:2021-2027.
-
(1984)
Biochem. Pharmacol.
, vol.33
, pp. 2021-2027
-
-
Dekant, W.1
Metzler, M.2
Henschler, D.3
-
16
-
-
0022724047
-
Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: Bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity
-
Dekant, W., Metzler, M., and Henschler, D., 1986a, Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: Bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity. J. Biochem. Toxicol. 1:57-72.
-
(1986)
J. Biochem. Toxicol.
, vol.1
, pp. 57-72
-
-
Dekant, W.1
Metzler, M.2
Henschler, D.3
-
17
-
-
0022503191
-
Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: A possible explanation for its nephrocarcinogenicity in male rats
-
Dekant, W., Metzler, M., and Henschler, D., 1986b, Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: A possible explanation for its nephrocarcinogenicity in male rats. Biochem. Pharmacol. 35:2455-2458.
-
(1986)
Biochem. Pharmacol.
, vol.35
, pp. 2455-2458
-
-
Dekant, W.1
Metzler, M.2
Henschler, D.3
-
18
-
-
0023023223
-
Bacterial ß-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene
-
Dekant, W., Vamvakas, S., Berthold, K., Schmidt, S., Wild, D., and Henschler, D., 1986c, Bacterial ß-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene. Chem.-Biol. Interactions 60:31-45.
-
(1986)
Chem.-Biol. Interactions
, vol.60
, pp. 31-45
-
-
Dekant, W.1
Vamvakas, S.2
Berthold, K.3
Schmidt, S.4
Wild, D.5
Henschler, D.6
-
19
-
-
0023447097
-
Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
Dekant, W., Lash, L. H., and Anders, M. W., 1987a, Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine. Proc. Natl. Acad. Sci. USA 84:7443-7447.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 7443-7447
-
-
Dekant, W.1
Lash, L.H.2
Anders, M.W.3
-
20
-
-
0023500127
-
Bioactivation of tetrachloroethylene: Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation
-
Dekant, W., Martens, G., Vamvakas, S., Metzler, M., and Henschler, D., 1987b, Bioactivation of tetrachloroethylene: Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation. Drug Metab. Dispos. 15:702-709.
-
(1987)
Drug Metab. Dispos.
, vol.15
, pp. 702-709
-
-
Dekant, W.1
Martens, G.2
Vamvakas, S.3
Metzler, M.4
Henschler, D.5
-
21
-
-
0023782840
-
Metabolism of hexachloro-1,3-butadiene in mice: In vivo and in vitro evidence for activation by glutathione conjugation
-
Dekant, W., Schrenk, D., Vamvakas, S., and Henschler, D., 1988a, Metabolism of hexachloro-1,3-butadiene in mice: in vivo and in vitro evidence for activation by glutathione conjugation. Xenobiotica 18:803-816.
-
(1988)
Xenobiotica
, vol.18
, pp. 803-816
-
-
Dekant, W.1
Schrenk, D.2
Vamvakas, S.3
Henschler, D.4
-
22
-
-
0023730066
-
Enzymatic conjugation of hexachloro-1,3-butadiene with glutathione: Formation of 1-(glutathion-S-yl)-1,2,3,4,4-pentachlorobuta-1,3-diene and 1,4-bis(glutathion-S-yl)-1,2,3,4- tetrachlorobuta-1,3-diene
-
Dekant, W., Vamvakas, S., Henschler, D., and Anders, M. W., 1988b, Enzymatic conjugation of hexachloro-1,3-butadiene with glutathione: Formation of 1-(glutathion-S-yl)-1,2,3,4,4-pentachlorobuta-1,3-diene and 1,4-bis(glutathion-S-yl)-1,2,3,4- tetrachlorobuta-1,3-diene. Drug. Metab. Dispos. 16:701-706.
-
(1988)
Drug. Metab. Dispos.
, vol.16
, pp. 701-706
-
-
Dekant, W.1
Vamvakas, S.2
Henschler, D.3
Anders, M.W.4
-
23
-
-
0023937244
-
Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate ß-lyase
-
Dekant, W., Berthold, K., Vamvakas, S., Henschler, D., and Anders, M. W., 1988c, Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate ß-lyase. Chem. Res. Toxicol. 1:175-178.
-
(1988)
Chem. Res. Toxicol.
, vol.1
, pp. 175-178
-
-
Dekant, W.1
Berthold, K.2
Vamvakas, S.3
Henschler, D.4
Anders, M.W.5
-
24
-
-
0024604605
-
Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: Formation of toxic and mutagenic intermediates by cysteine conjugate ß-lyase
-
Dekant, W., Vamvakas, S., and Anders, M. W., 1989, Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: Formation of toxic and mutagenic intermediates by cysteine conjugate ß-lyase. Drug Metab. Rev. 20:43-83.
-
(1989)
Drug Metab. Rev.
, vol.20
, pp. 43-83
-
-
Dekant, W.1
Vamvakas, S.2
Anders, M.W.3
-
25
-
-
0025025859
-
Biosynthesis, bioactivation, and mutagenicity of S-conjugates
-
Dekant, W., Vamvakas, S., and Anders, M. W., 1990a, Biosynthesis, bioactivation, and mutagenicity of S-conjugates. Tox. Lett. 53:53-58.
-
(1990)
Tox. Lett.
, vol.53
, pp. 53-58
-
-
Dekant, W.1
Vamvakas, S.2
Anders, M.W.3
-
26
-
-
0025084787
-
A mechanism of haloalkene-induced renal carcinogenesis
-
Dekant, W., Vamvakas, S., Koob, M., Köchling, A., Kanhai, W., Müller, D., and Henschler, D., 1990b, A mechanism of haloalkene-induced renal carcinogenesis. Environ. Health Perspect. 88:107-110.
-
(1990)
Environ. Health Perspect.
, vol.88
, pp. 107-110
-
-
Dekant, W.1
Vamvakas, S.2
Koob, M.3
Köchling, A.4
Kanhai, W.5
Müller, D.6
Henschler, D.7
-
27
-
-
0025129134
-
Metabolism of trichloroethene: In vivo and in vitro evidence for activation by glutathione conjugation
-
Dekant, W., Koob, M., and Henschler, D., 1990c, Metabolism of trichloroethene: in vivo and in vitro evidence for activation by glutathione conjugation. Chem.-Biol. Interact. 73:89-101.
-
(1990)
Chem.-Biol. Interact.
, vol.73
, pp. 89-101
-
-
Dekant, W.1
Koob, M.2
Henschler, D.3
-
28
-
-
0000666578
-
Thioketene formation from α-haloalkenyl 2-nitrophenyl disulfides: Models for biological reactive intermediates of cytotoxic S-conjugates
-
Dekant, W., Urban, G., Görsman, C., and Anders, M. W., 1991, Thioketene formation from α-haloalkenyl 2-nitrophenyl disulfides: Models for biological reactive intermediates of cytotoxic S-conjugates. J. Amer. Chem. Soc. 113:5120-5122.
-
(1991)
J. Amer. Chem. Soc.
, vol.113
, pp. 5120-5122
-
-
Dekant, W.1
Urban, G.2
Görsman, C.3
Anders, M.W.4
-
29
-
-
0026461433
-
Mechanisms of xenobiotic-induced renal carcinogenicity
-
Dekant, W., and Vamvakas, S., 1992, Mechanisms of xenobiotic-induced renal carcinogenicity. Adv. Pharmacol. 23:297-337.
-
(1992)
Adv. Pharmacol.
, vol.23
, pp. 297-337
-
-
Dekant, W.1
Vamvakas, S.2
-
30
-
-
0020284277
-
The enzymatic reaction of chlorotrifluoroethylene with glutathione
-
Dohn, D. R., and Anders, M. W., 1982, The enzymatic reaction of chlorotrifluoroethylene with glutathione. Biochem. Biophys. Res. Commun. 109:1339-1345.
-
(1982)
Biochem. Biophys. Res. Commun.
, vol.109
, pp. 1339-1345
-
-
Dohn, D.R.1
Anders, M.W.2
-
31
-
-
0001086729
-
Thiiranium ion intermediates in the formation and reactions of S-(2-haloethyl)-L-cysteines
-
Dohn, D. R., and Casida, J. E., 1987, Thiiranium ion intermediates in the formation and reactions of S-(2-haloethyl)-L-cysteines. Bioorganic Chemistry 15:115-124.
-
(1987)
Bioorganic Chemistry
, vol.15
, pp. 115-124
-
-
Dohn, D.R.1
Casida, J.E.2
-
32
-
-
0025363803
-
Activation and detoxication of aminophenols. II. Synthesis and structural elucidation of various thiol addition products of 1,4-benzoquinoneimine and N-acetyl-1,4-benzoquinoneimine
-
Eckert, K.-G., Eyer, P., Sonnenbichler, J., and Zetl, I., 1990, Activation and detoxication of aminophenols. II. Synthesis and structural elucidation of various thiol addition products of 1,4-benzoquinoneimine and N-acetyl-1,4-benzoquinoneimine. Xenobiotica 20:333-350.
-
(1990)
Xenobiotica
, vol.20
, pp. 333-350
-
-
Eckert, K.-G.1
Eyer, P.2
Sonnenbichler, J.3
Zetl, I.4
-
33
-
-
0020038871
-
Nephrotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate, and its metabolites
-
Elliot, W. C., Lynn, R. K., Hougton, D. C., Kennish, J. M., and Bennett, W. M., 1982, Nephrotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate, and its metabolites. Toxicol. Appl. Pharmacol. 63:179-182.
-
(1982)
Toxicol. Appl. Pharmacol.
, vol.63
, pp. 179-182
-
-
Elliot, W.C.1
Lynn, R.K.2
Hougton, D.C.3
Kennish, J.M.4
Bennett, W.M.5
-
34
-
-
0023647088
-
7-guanyl)ethyl) adducts by the postulated S-(2-chloroethyl)cysteinyl and S-(2-chloroethyl)glutathionyl conjugates of 1,2-dichloroethane
-
7-guanyl)ethyl) adducts by the postulated S-(2-chloroethyl)cysteinyl and S-(2-chloroethyl)glutathionyl conjugates of 1,2-dichloroethane. Biochemistiy 26:2028-2033.
-
(1987)
Biochemistiy
, vol.26
, pp. 2028-2033
-
-
Foureman, G.L.1
Reed, D.J.2
-
35
-
-
0026349245
-
Nephrotoxicity of 4-aminophenol glutathione conjugate
-
Fowler, L. M., Moore, R. B., Foster, J. R., and Lock, E. A., 1991, Nephrotoxicity of 4-aminophenol glutathione conjugate. Human Exper. Toxicol. 10:451-459.
-
(1991)
Human Exper. Toxicol.
, vol.10
, pp. 451-459
-
-
Fowler, L.M.1
Moore, R.B.2
Foster, J.R.3
Lock, E.A.4
-
36
-
-
0024580448
-
Investigations into the biochemical effects of region-specific nephrotoxins
-
Gartland, K. P. R., Bonner, F. W., and Nicholson, J. K., 1989a, Investigations into the biochemical effects of region-specific nephrotoxins. Mol. Pharmacol. 35:242-250.
-
(1989)
Mol. Pharmacol.
, vol.35
, pp. 242-250
-
-
Gartland, K.P.R.1
Bonner, F.W.2
Nicholson, J.K.3
-
37
-
-
0024542035
-
Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F334 rat
-
Gartland, K. P. R., Donner, F. W., Timbrell, J. A., and Nicholson, J. K., 1989b, Biochemical characterisation of para-aminophenol-induced nephrotoxic lesions in the F334 rat. Arch. Toxicol. 63:97-106.
-
(1989)
Arch. Toxicol.
, vol.63
, pp. 97-106
-
-
Gartland, K.P.R.1
Donner, F.W.2
Timbrell, J.A.3
Nicholson, J.K.4
-
38
-
-
0025092255
-
Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fisher 334 rat
-
Gartland, K. P. R., Eason, C. T., Bonner, F. W., and Nicholson, J. K., 1990, Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fisher 334 rat. Arch. Toxicol. 64, 14-25.
-
(1990)
Arch. Toxicol.
, vol.64
, pp. 14-25
-
-
Gartland, K.P.R.1
Eason, C.T.2
Bonner, F.W.3
Nicholson, J.K.4
-
39
-
-
0028078458
-
The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride
-
Graves, R. J., Callender, R. D., and Green, T., 1994a, The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride. Mutat. Res. 320:235-243.
-
(1994)
Mutat. Res.
, vol.320
, pp. 235-243
-
-
Graves, R.J.1
Callender, R.D.2
Green, T.3
-
40
-
-
0028284646
-
Relationship between hepatic DNA damage and methylene chloride-induced hepatocarcinogenicity in B6C3F1 mice
-
Graves, R. J., Coutts, C., Eyton-Jones, H., and Green, T., 1994b, Relationship between hepatic DNA damage and methylene chloride-induced hepatocarcinogenicity in B6C3F1 mice. Carcinogenesis 15:991-996.
-
(1994)
Carcinogenesis
, vol.15
, pp. 991-996
-
-
Graves, R.J.1
Coutts, C.2
Eyton-Jones, H.3
Green, T.4
-
41
-
-
0020510027
-
The metabolic activation of dichloromethane and chlorofluoromethane in a bacterial mutation assay using Salmonella typhimurium
-
Green, T., 1983, The metabolic activation of dichloromethane and chlorofluoromethane in a bacterial mutation assay using Salmonella typhimurium. Mutat. Res. 118:277-288.
-
(1983)
Mutat. Res.
, vol.118
, pp. 277-288
-
-
Green, T.1
-
42
-
-
0021867892
-
Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes
-
Green, T., and Odum, J., 1985, Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chloro- and fluoroalkenes. Chem.-Biol. Interact. 54:15-31.
-
(1985)
Chem.-Biol. Interact.
, vol.54
, pp. 15-31
-
-
Green, T.1
Odum, J.2
-
43
-
-
0023891457
-
Macromolecular interactions of inhaled methylene chloride in rats and mice
-
Green, T., Provan, W. M., Collinge, D. C., and Guest, A. E., 1988a, Macromolecular interactions of inhaled methylene chloride in rats and mice. Toxicol. Appl. Pharmacol. 93:1-10.
-
(1988)
Toxicol. Appl. Pharmacol.
, vol.93
, pp. 1-10
-
-
Green, T.1
Provan, W.M.2
Collinge, D.C.3
Guest, A.E.4
-
44
-
-
0345104101
-
Methylene chloride, dichloromethan: Human risk assessment using experimental animal data
-
Green, T., Provan, W. M., Dugard, P. H., and Cook, S. K., 1988b, Methylene chloride, dichloromethan: Human risk assessment using experimental animal data. ECETOC Technical Report 32:1-62.
-
(1988)
ECETOC Technical Report
, vol.32
, pp. 1-62
-
-
Green, T.1
Provan, W.M.2
Dugard, P.H.3
Cook, S.K.4
-
45
-
-
0018973350
-
In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes
-
Guengerich, F. P., Crawford, W. M. J., Domoradzki, J. Y., Macdonald, T. L., and Watanabe, P. G., 1980, In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes. Toxicol. Appl. Pharmacol. 55:303-317.
-
(1980)
Toxicol. Appl. Pharmacol.
, vol.55
, pp. 303-317
-
-
Guengerich, F.P.1
Crawford, W.M.J.2
Domoradzki, J.Y.3
Macdonald, T.L.4
Watanabe, P.G.5
-
47
-
-
0027093458
-
The effects of 2,3,5-(triglutathion-S-yl)hydroquinone on renal mitochondrial respiratory function in vivo and in vitro: Possible role in cytotoxicity
-
Hill, B. A., Monks, T. J., and Lau, S. S., 1992, The effects of 2,3,5-(triglutathion-S-yl)hydroquinone on renal mitochondrial respiratory function in vivo and in vitro: Possible role in cytotoxicity. Toxicol. Appl. Pharmacol. 117:165-171.
-
(1992)
Toxicol. Appl. Pharmacol.
, vol.117
, pp. 165-171
-
-
Hill, B.A.1
Monks, T.J.2
Lau, S.S.3
-
48
-
-
0027297075
-
Identification of multi-S-substituted conjugates of hydroquinones by HPLC-coulometric electrode array analysis and mass spectroscopy
-
Hill, B. A., Kleiner, H. E., Ryan, E. A., Dulik, D. M., Monks, T. J., and Lau, S. S., 1993, Identification of multi-S-substituted conjugates of hydroquinones by HPLC-coulometric electrode array analysis and mass spectroscopy. Chem. Res. Toxicol. 6:459-469.
-
(1993)
Chem. Res. Toxicol.
, vol.6
, pp. 459-469
-
-
Hill, B.A.1
Kleiner, H.E.2
Ryan, E.A.3
Dulik, D.M.4
Monks, T.J.5
Lau, S.S.6
-
49
-
-
0026341969
-
DNA damage and cell death induced by 1,2-dibromo-3-chloropropane (DBCP) and structural analogs in monolayer culture of rat hepatocytes: 3-Aminobenzamide inhibits the toxicity of DBCP
-
Holme, J. A., Soderlund, E. J., Brunborg, G., Lag, M., Nelsdon, S. D., and Dybing, E., 1991, DNA damage and cell death induced by 1,2-dibromo-3-chloropropane (DBCP) and structural analogs in monolayer culture of rat hepatocytes: 3-Aminobenzamide inhibits the toxicity of DBCP. Cell Biol. Toxicol. 7:413-432.
-
(1991)
Cell Biol. Toxicol.
, vol.7
, pp. 413-432
-
-
Holme, J.A.1
Soderlund, E.J.2
Brunborg, G.3
Lag, M.4
Nelsdon, S.D.5
Dybing, E.6
-
50
-
-
0025075387
-
Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives
-
Humphreys, W. G., Kim, D. H., Cmarik, J. L., Shimada, T., and Guengerich, D. P., 1990, Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives. Biochemistry 29:10342-10350.
-
(1990)
Biochemistry
, vol.29
, pp. 10342-10350
-
-
Humphreys, W.G.1
Kim, D.H.2
Cmarik, J.L.3
Shimada, T.4
Guengerich, D.P.5
-
51
-
-
0025925225
-
Isolation and characterization of N7-guanyl adducts derived from 1,2-dibromo-3-chloropropane
-
Humphreys, W. G., Kim, D. H., and Guengerich, F. P., 1991, Isolation and characterization of N7-guanyl adducts derived from 1,2-dibromo-3-chloropropane. Chem. Res. Toxicol. 4:445-453.
-
(1991)
Chem. Res. Toxicol.
, vol.4
, pp. 445-453
-
-
Humphreys, W.G.1
Kim, D.H.2
Guengerich, F.P.3
-
53
-
-
0021241496
-
Glutathione-mediated binding of dibromoalkanes to DNA: Specificity of rat glutathione-S-transferases and dibromoalkane structure
-
Inskeep, P. B., and Guengerich, F. P., 1984, Glutathione-mediated binding of dibromoalkanes to DNA: Specificity of rat glutathione-S-transferases and dibromoalkane structure. Carcinogenesis 5:805-808.
-
(1984)
Carcinogenesis
, vol.5
, pp. 805-808
-
-
Inskeep, P.B.1
Guengerich, F.P.2
-
54
-
-
0019955996
-
Necrosis of the pars recta, S3 segment of the rat kidney produced by hexachloro-1:3-butadiene
-
Ishmael, J., Pratt, I., and Lock, E. A., 1982, Necrosis of the pars recta, S3 segment) of the rat kidney produced by hexachloro-1:3-butadiene. J. Pathol. 138:99-113.
-
(1982)
J. Pathol.
, vol.138
, pp. 99-113
-
-
Ishmael, J.1
Pratt, I.2
Lock, E.A.3
-
55
-
-
0024818103
-
In vitro dipeptide, nucleoside, and glutathione alkylation by S-(2-chloroethyl)glutathione and S-(2-chloroethyl)-L-cysteine
-
Jean, P. A., and Reed, D. J., 1989, In vitro dipeptide, nucleoside, and glutathione alkylation by S-(2-chloroethyl)glutathione and S-(2-chloroethyl)-L-cysteine. Chem. Res. Toxicol. 2:455-460.
-
(1989)
Chem. Res. Toxicol.
, vol.2
, pp. 455-460
-
-
Jean, P.A.1
Reed, D.J.2
-
56
-
-
0018792860
-
The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane
-
Jones, A. R., Fakhouri, G., and Gadiel, P., 1979, The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane. Experienta 35:1432-1434.
-
(1979)
Experienta
, vol.35
, pp. 1432-1434
-
-
Jones, A.R.1
Fakhouri, G.2
Gadiel, P.3
-
57
-
-
0020632378
-
Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase
-
Josephy, P. D., Eling, T. E., and Mason, R. P., 1983, Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase. Mol. Pharmacol. 23:461-466.
-
(1983)
Mol. Pharmacol.
, vol.23
, pp. 461-466
-
-
Josephy, P.D.1
Eling, T.E.2
Mason, R.P.3
-
58
-
-
0024514780
-
Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation
-
Kanhai, W., Dekant, W., and Henschler, D., 1989, Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation. Chem. Res. Toxicol. 2:51-56.
-
(1989)
Chem. Res. Toxicol.
, vol.2
, pp. 51-56
-
-
Kanhai, W.1
Dekant, W.2
Henschler, D.3
-
60
-
-
84965986155
-
Enzyme kinetics of methylene chloride: MFO and GST activities in female B6C3F1 mice liver and lung in relation to aging and chronic dosing
-
Kermani, H. R. S., Sloane, R. A., Moorman, M. P., Yang, R. S. H., Ray, C., and Reitz, R. H., 1990, Enzyme kinetics of methylene chloride: MFO and GST activities in female B6C3F1 mice liver and lung in relation to aging and chronic dosing. Toxicologist 10:186-.
-
(1990)
Toxicologist
, vol.10
, pp. 186
-
-
Kermani, H.R.S.1
Sloane, R.A.2
Moorman, M.P.3
Yang, R.S.H.4
Ray, C.5
Reitz, R.H.6
-
61
-
-
0024424137
-
Excretion of the mercapturic acid S-[2-(N7-guanyl)ethyl]-N-acetyl-cysteine in urine following administration of ethylene dibromide to rats
-
Kim, D.-H., and Guengerich, F. P., 1989, Excretion of the mercapturic acid S-[2-(N7-guanyl)ethyl]-N-acetyl-cysteine in urine following administration of ethylene dibromide to rats. Cancer Res. 499:5843-5847.
-
(1989)
Cancer Res.
, vol.499
, pp. 5843-5847
-
-
Kim, D.-H.1
Guengerich, F.P.2
-
62
-
-
0025190253
-
Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: Effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation
-
Kim, D.-H., and Guengerich, F. P., 1990, Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: Effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis 11:419-424.
-
(1990)
Carcinogenesis
, vol.11
, pp. 419-424
-
-
Kim, D.-H.1
Guengerich, F.P.2
-
63
-
-
0003043641
-
In vivo and in vitro formation of several S-conjugates of hydroquinone
-
Kleiner, H. E., Hill, B. A., Monks, T. J., and Lau, S. S., 1992, In vivo and in vitro formation of several S-conjugates of hydroquinone. Toxicologist 12:1350-1350.
-
(1992)
Toxicologist
, vol.12
, pp. 1350-1350
-
-
Kleiner, H.E.1
Hill, B.A.2
Monks, T.J.3
Lau, S.S.4
-
64
-
-
0026668526
-
p-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates
-
Klos, C., Koob, M., Kramer, C., and Dekant, W., 1992, p-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates. Toxicol. Appl. Pharmacol. 115:98-106.
-
(1992)
Toxicol. Appl. Pharmacol.
, vol.115
, pp. 98-106
-
-
Klos, C.1
Koob, M.2
Kramer, C.3
Dekant, W.4
-
65
-
-
0017712414
-
Results of a two year chronic toxicity study with hexachlorobutadiene in rats
-
Kociha, R. J., Keyes, D. G., Jersey, G. C., Ballard, J. J., Dittenber, D. A., Quast, J. F., Wade, L. E., Humiston, C. G., and Schwetz, B. A., 1977, Results of a two year chronic toxicity study with hexachlorobutadiene in rats. Am. Ind. Hyg. Assoc. J. 38:589-602.
-
(1977)
Am. Ind. Hyg. Assoc. J.
, vol.38
, pp. 589-602
-
-
Kociha, R.J.1
Keyes, D.G.2
Jersey, G.C.3
Ballard, J.J.4
Dittenber, D.A.5
Quast, J.F.6
Wade, L.E.7
Humiston, C.G.8
Schwetz, B.A.9
-
66
-
-
0025670109
-
Metabolism of hexafluoroproene - Evidence for bioactivation by glutathione conjugate formation in the kidney
-
Koob, M., and Dekant, W., 1990, Metabolism of hexafluoroproene - Evidence for bioactivation by glutathione conjugate formation in the kidney. Drug. Metab. Dispos. 18:911-916.
-
(1990)
Drug. Metab. Dispos.
, vol.18
, pp. 911-916
-
-
Koob, M.1
Dekant, W.2
-
67
-
-
0026079136
-
Bioactivation of xenobiotics by formation of toxic glutathione conjugates
-
Koob, M., and Dekant, W., 1991, Bioactivation of xenobiotics by formation of toxic glutathione conjugates. Chem.-Biol. Interact. 77:107-136.
-
(1991)
Chem.-Biol. Interact.
, vol.77
, pp. 107-136
-
-
Koob, M.1
Dekant, W.2
-
68
-
-
0024321045
-
Role of P-450 activity and glutathione levels in 1,2-dibromo-3-chloropropane tissue distribution, renal necrosis and in vivo DNA damage
-
Lag, M., Omichinski, J. G., Soderlund, E. J., Brunborg, G., Holme, J. A., Dahl, J. E., Nelson, S. D., and Dybing, E., 1989a, Role of P-450 activity and glutathione levels in 1,2-dibromo-3-chloropropane tissue distribution, renal necrosis and in vivo DNA damage. Toxicology 56:273-288.
-
(1989)
Toxicology
, vol.56
, pp. 273-288
-
-
Lag, M.1
Omichinski, J.G.2
Soderlund, E.J.3
Brunborg, G.4
Holme, J.A.5
Dahl, J.E.6
Nelson, S.D.7
Dybing, E.8
-
69
-
-
0024453332
-
Species differences in testicular necrosis and DNA damage, distribution and metabolism of 1,2-dibromo-3-chloropropane (DBCP)
-
Lag, M., Soderlund, E. J., Brunborg, G., Dahl, J. E., Holme, J. A., Omichinski, J. G., Nelson, S. D., and Dybing, E., 1989b, Species differences in testicular necrosis and DNA damage, distribution and metabolism of 1,2-dibromo-3-chloropropane (DBCP). Toxicology 58:133-144.
-
(1989)
Toxicology
, vol.58
, pp. 133-144
-
-
Lag, M.1
Soderlund, E.J.2
Brunborg, G.3
Dahl, J.E.4
Holme, J.A.5
Omichinski, J.G.6
Nelson, S.D.7
Dybing, E.8
-
70
-
-
0021142363
-
Identification of 2-bromohydroquinone as a metabolite of bromobenzene and o-bromophenol: Implications for bromobenzene-induced nephrotoxicity
-
Lau, S. S., Monks, T. J., and Gillette, J. R., 1984, Identification of 2-bromohydroquinone as a metabolite of bromobenzene and o-bromophenol: Implications for bromobenzene-induced nephrotoxicity. J. Pharmacol. Exp. Ther. 230:360-366.
-
(1984)
J. Pharmacol. Exp. Ther.
, vol.230
, pp. 360-366
-
-
Lau, S.S.1
Monks, T.J.2
Gillette, J.R.3
-
71
-
-
0023912849
-
Differential uptake of isomeric 2-bromohydroquinone-glutathione conjugates into kidney slices
-
Lau, S. S., McMenamin, M. G., and Monks, T. J., 1988a, Differential uptake of isomeric 2-bromohydroquinone-glutathione conjugates into kidney slices. Biochem. Biophys. Res. Commun. 152:223-230.
-
(1988)
Biochem. Biophys. Res. Commun.
, vol.152
, pp. 223-230
-
-
Lau, S.S.1
McMenamin, M.G.2
Monks, T.J.3
-
72
-
-
0024237151
-
Sequential oxidation and glutathione addition to 1,4-benzoquinone: Correlation of toxicity with increased glutathione substitution
-
Lau, S. S., Hill, B. A., Highet, R. J., and Monks, T. J., 1988b, Sequential oxidation and glutathione addition to 1,4-benzoquinone: Correlation of toxicity with increased glutathione substitution. Mol. Pharmacol. 34:829-836.
-
(1988)
Mol. Pharmacol.
, vol.34
, pp. 829-836
-
-
Lau, S.S.1
Hill, B.A.2
Highet, R.J.3
Monks, T.J.4
-
73
-
-
0025327599
-
Differences in the localization and extent of the renal proximal tubular necrosis caused by mercapturic acid and glutathione conjugates of 1,4-naphthoquinone and menadione
-
Lau, S. S., Jones, T. W., Highet, R. J., Hill, B., and Monks, T. J., 1990, Differences in the localization and extent of the renal proximal tubular necrosis caused by mercapturic acid and glutathione conjugates of 1,4-naphthoquinone and menadione. Toxicol. Appl. Pharmacol. 104:334-350.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.104
, pp. 334-350
-
-
Lau, S.S.1
Jones, T.W.2
Highet, R.J.3
Hill, B.4
Monks, T.J.5
-
74
-
-
0025213022
-
The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of γ-glutamyl transpeptidase inhibition
-
Lau, S. S., and Monks, T. J., 1990, The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of γ-glutamyl transpeptidase inhibition. Toxicol. Appl. Pharmacol. 103:121-132.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.103
, pp. 121-132
-
-
Lau, S.S.1
Monks, T.J.2
-
75
-
-
0023761451
-
Studies on the mechanism of nephrotoxicity and nephrocarcinogenicity of halogenated alkenes
-
Lock, E. A., 1988, Studies on the mechanism of nephrotoxicity and nephrocarcinogenicity of halogenated alkenes. CRC Crit Rev. Toxicol. 19, 23-42.
-
(1988)
CRC Crit Rev. Toxicol.
, vol.19
, pp. 23-42
-
-
Lock, E.A.1
-
76
-
-
0024516118
-
Mechanism of nephrotoxic action due to organohalogenated compounds
-
Lock, E. A., 1989, Mechanism of nephrotoxic action due to organohalogenated compounds. Tox. Lett. 46:93-106.
-
(1989)
Tox. Lett.
, vol.46
, pp. 93-106
-
-
Lock, E.A.1
-
77
-
-
0020080442
-
Metabolism, distribution, and excretion of the flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) in the rat: Identification of mutagenic and nephrotoxic metabolites
-
Lynn, R. K., Garvie-Gould, C., Wong, K., and Kennish, J. M., 1982, Metabolism, distribution, and excretion of the flame retardant tris(2,3-dibromopropyl)phosphate (Tris-BP) in the rat: Identification of mutagenic and nephrotoxic metabolites. Toxicol. Appl. Pharmacol. 63:105-119.
-
(1982)
Toxicol. Appl. Pharmacol.
, vol.63
, pp. 105-119
-
-
Lynn, R.K.1
Garvie-Gould, C.2
Wong, K.3
Kennish, J.M.4
-
78
-
-
0026061606
-
Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice
-
Mahmood, N. A., Overstreet, D., and Burka, L. T., 1991, Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice. Drug Metab. Dispos. 19:411-418.
-
(1991)
Drug Metab. Dispos.
, vol.19
, pp. 411-418
-
-
Mahmood, N.A.1
Overstreet, D.2
Burka, L.T.3
-
79
-
-
0023722003
-
Enhancement of DMN-induced kidney tumors by 1,2-dichlorovinylcysteine in Swiss-Webster mice
-
Meadows, S. D., Gandolfi, A. J., Nagle, R. B., and Shively, J. W., 1988, Enhancement of DMN-induced kidney tumors by 1,2-dichlorovinylcysteine in Swiss-Webster mice. Drug Chem. Toxicol. 11:307-318.
-
(1988)
Drug Chem. Toxicol.
, vol.11
, pp. 307-318
-
-
Meadows, S.D.1
Gandolfi, A.J.2
Nagle, R.B.3
Shively, J.W.4
-
80
-
-
0024264526
-
Glutathione metabolism and its selective modification
-
Meister, A., 1988, Glutathione metabolism and its selective modification. J. Biol. Chem. 263:17205-17208.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 17205-17208
-
-
Meister, A.1
-
81
-
-
0026468245
-
Commentary: On the antioxidant effects of ascorbic acid and glutathione
-
Meister, A., 1992, Commentary: On the antioxidant effects of ascorbic acid and glutathione. Biochem. Pharmacol. 44:1905-1915.
-
(1992)
Biochem. Pharmacol.
, vol.44
, pp. 1905-1915
-
-
Meister, A.1
-
82
-
-
0025875883
-
Inhibition of γ-glutainyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones
-
Mertens, J. J., Temmink, J. H., Bladeren, P. J., Jones, T. W., Lo, H. H., Lau, S. S., and Monks, T. J., 1991, Inhibition of γ-glutainyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones. Toxicol. Appl. Pharmacol. 110:45-60.
-
(1991)
Toxicol. Appl. Pharmacol.
, vol.110
, pp. 45-60
-
-
Mertens, J.J.1
Temmink, J.H.2
Bladeren, P.J.3
Jones, T.W.4
Lo, H.H.5
Lau, S.S.6
Monks, T.J.7
-
83
-
-
0026033569
-
Theta, a new class of glutathione transferases purified from rat and man
-
Meyer, D. J., Coles, B., Pemple, S. E., Gilmore, K. S., Fraser, G. M., and Ketterer, B., 1991, Theta, a new class of glutathione transferases purified from rat and man. Biochem. J. 274:409-414.
-
(1991)
Biochem. J.
, vol.274
, pp. 409-414
-
-
Meyer, D.J.1
Coles, B.2
Pemple, S.E.3
Gilmore, K.S.4
Fraser, G.M.5
Ketterer, B.6
-
84
-
-
0022380437
-
Glutathione conjugates of 2-bromohydroquinone are nephrotoxic
-
Monks, T. J., Lau, S. S., Highet, R. J., and Gillette, J. R., 1985, Glutathione conjugates of 2-bromohydroquinone are nephrotoxic. Drug Metab. Dispos. 13:553-559.
-
(1985)
Drug Metab. Dispos.
, vol.13
, pp. 553-559
-
-
Monks, T.J.1
Lau, S.S.2
Highet, R.J.3
Gillette, J.R.4
-
85
-
-
0023377867
-
Commentary: Renal transport processes and glutathione conjugate-mediated nephrotoxicity
-
Monks, T. J., and Lau, S. S., 1987, Commentary: Renal transport processes and glutathione conjugate-mediated nephrotoxicity. Drug Metab. Dispos. 15:437-441.
-
(1987)
Drug Metab. Dispos.
, vol.15
, pp. 437-441
-
-
Monks, T.J.1
Lau, S.S.2
-
86
-
-
0023761518
-
2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: Physiological, biochemical, and electrochemical determinants
-
Monks, T. J., Highet, R. J., and Lau, S. S., 1988, 2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: Physiological, biochemical, and electrochemical determinants. Mol. Pharmacol. 34:492-500.
-
(1988)
Mol. Pharmacol.
, vol.34
, pp. 492-500
-
-
Monks, T.J.1
Highet, R.J.2
Lau, S.S.3
-
87
-
-
0003043294
-
Sulphur conjugate-mediated toxicity
-
Monks, T. J., and Lau, S. S., 1989, Sulphur conjugate-mediated toxicity. Rev. Biochem. Toxicol. 10:41-90.
-
(1989)
Rev. Biochem. Toxicol.
, vol.10
, pp. 41-90
-
-
Monks, T.J.1
Lau, S.S.2
-
88
-
-
0025504568
-
Glutathione conjugate mediated toxicities
-
Monks, T. J., Anders, M. W., Dekant, W., Stevens, J. L., Lau, S. S., and Bladeren, P. J., 1990, Glutathione conjugate mediated toxicities. Toxicol. Appl. Pharmacol. 106:1-19.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.106
, pp. 1-19
-
-
Monks, T.J.1
Anders, M.W.2
Dekant, W.3
Stevens, J.L.4
Lau, S.S.5
Bladeren, P.J.6
-
89
-
-
0025208253
-
Glutathione, γ-glutamyl transpeptidase, and the mercapturic acid pathway as modulators of 2-bromohydroquinone oxidation
-
Monks, T. J., and Lau, S. S., 1990, Glutathione, γ-glutamyl transpeptidase, and the mercapturic acid pathway as modulators of 2-bromohydroquinone oxidation. Toxicol. Appl. Pharmacol. 103:557-563.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.103
, pp. 557-563
-
-
Monks, T.J.1
Lau, S.S.2
-
90
-
-
0021236594
-
The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity
-
Nash, J. A., King, L. J., Lock, E. A., and Green, T., 1984, The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity. Toxicol. Appl. Pharmacol. 73:124-137.
-
(1984)
Toxicol. Appl. Pharmacol.
, vol.73
, pp. 124-137
-
-
Nash, J.A.1
King, L.J.2
Lock, E.A.3
Green, T.4
-
91
-
-
0004026485
-
Carcinogenesis bioassay of tetrachloroethylene
-
National Cancer Institute NCI, 1986a, Carcinogenesis bioassay of tetrachloroethylene. National Toxicology Program Technical Report 232.
-
(1986)
National Toxicology Program Technical Report
, vol.232
-
-
-
92
-
-
0004328487
-
Carcinogenesis bioassay of trichloroethylene
-
National Cancer Institute NCI, 1986b, Carcinogenesis bioassay of trichloroethylene. National Toxicology Program Technical Report 311.
-
(1986)
National Toxicology Program Technical Report
, vol.311
-
-
-
93
-
-
0020409270
-
Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat
-
Newton, J. F., Kuo, C.-H., Gemborys, M. W., Mudge, G. H., and Hook, J. B., 1982, Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat. Toxicol. Appl. Pharmacol. 65:336-344.
-
(1982)
Toxicol. Appl. Pharmacol.
, vol.65
, pp. 336-344
-
-
Newton, J.F.1
Kuo, C.-H.2
Gemborys, M.W.3
Mudge, G.H.4
Hook, J.B.5
-
94
-
-
0021681724
-
The metabolism and nephrotoxicity of tetrafluoroethylene in the rat
-
Odum, J., and Green, T., 1984, The metabolism and nephrotoxicity of tetrafluoroethylene in the rat. Toxicol. Appl. Pharmacol. 76:306-318.
-
(1984)
Toxicol. Appl. Pharmacol.
, vol.76
, pp. 306-318
-
-
Odum, J.1
Green, T.2
-
95
-
-
0024595728
-
Properties of the microsomal and cytosolic glutathione transferases involved in hexachloro-1:3-butadiene conjugation
-
Oesch, F., and Wolf, C. R., 1989, Properties of the microsomal and cytosolic glutathione transferases involved in hexachloro-1:3-butadiene conjugation. Biochem. Pharmacol. 38:353-359.
-
(1989)
Biochem. Pharmacol.
, vol.38
, pp. 353-359
-
-
Oesch, F.1
Wolf, C.R.2
-
96
-
-
0017589277
-
Renal and testicular damage following dermal application of the flame retardant tris(2,3-dibromopropyl)phosphate
-
Osterberg, R. E., Bierbower, G. W., and Hehir, R. M., 1977, Renal and testicular damage following dermal application of the flame retardant tris(2,3-dibromopropyl)phosphate. J. Toxicol. Environ. Health 3:979-987.
-
(1977)
J. Toxicol. Environ. Health
, vol.3
, pp. 979-987
-
-
Osterberg, R.E.1
Bierbower, G.W.2
Hehir, R.M.3
-
97
-
-
0008252723
-
Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione mediated binding of the carcinogen 1,2-dibromoethane to DNA
-
Ozawa, N., and Guengerich, F. P., 1983, Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione mediated binding of the carcinogen 1,2-dibromoethane to DNA. Proc. Natl. Acad. Sci. USA 80:5266-5270.
-
(1983)
Proc. Natl. Acad. Sci. USA
, vol.80
, pp. 5266-5270
-
-
Ozawa, N.1
Guengerich, F.P.2
-
98
-
-
0025153710
-
Gas chromatographic separation and determination of chloroacetic acids in water by a difluoroanilide derivatisation method
-
Ozawa, H., and Tsukioka, T., 1990, Gas chromatographic separation and determination of chloroacetic acids in water by a difluoroanilide derivatisation method. Analyst 115:1343-1347.
-
(1990)
Analyst
, vol.115
, pp. 1343-1347
-
-
Ozawa, H.1
Tsukioka, T.2
-
99
-
-
0025368304
-
Metabolic activation of 1,2-dibromo-3-chloropropane: Evidence for the formation of reactive episulfonium ion intermediates
-
Pearson, P. G., Soderlund, E. J., Dybing, E., and Nelson, S. D., 1990, Metabolic activation of 1,2-dibromo-3-chloropropane: Evidence for the formation of reactive episulfonium ion intermediates. Biochemistry 29:4971-4977.
-
(1990)
Biochemistry
, vol.29
, pp. 4971-4977
-
-
Pearson, P.G.1
Soderlund, E.J.2
Dybing, E.3
Nelson, S.D.4
-
100
-
-
0027311033
-
Metabolic activation of tris(2,3-dibromopropyl)phosphate to reactive intermediates. II. Covalent binding, reactive metabolite formation, and differential metabolite-specific DNA damage in vivo
-
Pearson, P. G., Omichinski, J. G., Holme, J. A., McClanahan, R. H., Brunborg, G., Soderlund, E. J., Dybing, E., and Nelson, S. D., 1993, Metabolic activation of tris(2,3-dibromopropyl)phosphate to reactive intermediates. II. Covalent binding, reactive metabolite formation, and differential metabolite-specific DNA damage in vivo. Toxicol. Appl. Pharmacol. 118:186-195.
-
(1993)
Toxicol. Appl. Pharmacol.
, vol.118
, pp. 186-195
-
-
Pearson, P.G.1
Omichinski, J.G.2
Holme, J.A.3
McClanahan, R.H.4
Brunborg, G.5
Soderlund, E.J.6
Dybing, E.7
Nelson, S.D.8
-
101
-
-
0023926239
-
Evidence for an episulfonium ion intermediate in the formation of S-[2-(N7-guanyl)ethyl]glutathione in DNA
-
Peterson, L. A., Harris, T. M., and Guengerich, F. P., 1988, Evidence for an episulfonium ion intermediate in the formation of S-[2-(N7-guanyl)ethyl]glutathione in DNA. J. Am. Chem. Soc. 110:3284-3291.
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 3284-3291
-
-
Peterson, L.A.1
Harris, T.M.2
Guengerich, F.P.3
-
102
-
-
0019470469
-
Effects of inhaled chlorotrifluoroethylene and hexafluoropropene on the rat kidney
-
Potter, C. L., Gandolfi, A. J., Nagle, R., and Clayton, J. W., 1981, Effects of inhaled chlorotrifluoroethylene and hexafluoropropene on the rat kidney. Toxicol. Appl. Pharmacol. 59:431-440.
-
(1981)
Toxicol. Appl. Pharmacol.
, vol.59
, pp. 431-440
-
-
Potter, C.L.1
Gandolfi, A.J.2
Nagle, R.3
Clayton, J.W.4
-
103
-
-
0026028088
-
Nephrotoxicity of glutathione conjugate of menadione (2-methyl-1,4-naphthoquinone) in the isolated perfused rat kidney. Role of metabolism by γ-glutamyltranspeptidase and probenecid-sensitive transport
-
Redegeld, F. A. M., Hofman, G. A., Loo, P. G. F., Koster, A. S., and Noordhoek, J., 1991, Nephrotoxicity of glutathione conjugate of menadione (2-methyl-1,4-naphthoquinone) in the isolated perfused rat kidney. Role of metabolism by γ-glutamyltranspeptidase and probenecid-sensitive transport. J. Pharmacol. Exptl. Therap. 256:665-669.
-
(1991)
J. Pharmacol. Exptl. Therap.
, vol.256
, pp. 665-669
-
-
Redegeld, F.A.M.1
Hofman, G.A.2
Loo, P.G.F.3
Koster, A.S.4
Noordhoek, J.5
-
104
-
-
0016686208
-
Generation and inhalation toxicity of dichloroacetylene
-
Reichert, D., Ewald, D., and Henschler, D., 1975, Generation and inhalation toxicity of dichloroacetylene. Fd Cosmet. Toxicol. 13:511-515.
-
(1975)
Fd Cosmet. Toxicol.
, vol.13
, pp. 511-515
-
-
Reichert, D.1
Ewald, D.2
Henschler, D.3
-
105
-
-
0022872132
-
Mercapturic acid formation is an activation and intermediary step in the metabolism of hexachlorobutadiene
-
Reichert, D., and Schuetz, S., 1986, Mercapturic acid formation is an activation and intermediary step in the metabolism of hexachlorobutadiene. Biochem. Pharmacol. 35:1271-1275.
-
(1986)
Biochem. Pharmacol.
, vol.35
, pp. 1271-1275
-
-
Reichert, D.1
Schuetz, S.2
-
106
-
-
0024515167
-
In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models
-
Reitz, R. H., Mendrala, A. L., and Gurengerich, F. P., 1989, In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models. Toxicol. Appl. Pharmacol. 97, 230-246.
-
(1989)
Toxicol. Appl. Pharmacol.
, vol.97
, pp. 230-246
-
-
Reitz, R.H.1
Mendrala, A.L.2
Gurengerich, F.P.3
-
107
-
-
0027333091
-
Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris(2,3-dibromo-propyl)phosphate in Salmonella TA100 expressing human glutathione S-transferases
-
Simula, T. P., Glancey, M. J., Söderlund, E. J., Dybing, E., and Wolf, C. R., 1993, Increased mutagenicity of 1,2-dibromo-3-chloropropane and tris(2,3-dibromo-propyl)phosphate in Salmonella TA100 expressing human glutathione S-transferases. Carcinogenesis 14:2303-2307.
-
(1993)
Carcinogenesis
, vol.14
, pp. 2303-2307
-
-
Simula, T.P.1
Glancey, M.J.2
Söderlund, E.J.3
Dybing, E.4
Wolf, C.R.5
-
108
-
-
0021718911
-
Metabolism in vitro of tris(2,3-dibromopropyl)-phosphate: Oxidative denomination and bis(2,3-dibromopropyl)phosphate formation as correlates of mutagenicity and covalent protein binding
-
Söderlund, E. J., Gordon, W. P., Nelson, S. D., Omichinski, J. G., and Dybing, E., 1984, Metabolism in vitro of tris(2,3-dibromopropyl)-phosphate: oxidative denomination and bis(2,3-dibromopropyl)phosphate formation as correlates of mutagenicity and covalent protein binding. Biochem. Pharmacol. 33:4017-4023.
-
(1984)
Biochem. Pharmacol.
, vol.33
, pp. 4017-4023
-
-
Söderlund, E.J.1
Gordon, W.P.2
Nelson, S.D.3
Omichinski, J.G.4
Dybing, E.5
-
109
-
-
0002974521
-
Vapor toxicity of ethylene dichloride determined by experiments on laboratory animals
-
Spencer, H. C., Rowe, V. K., Adams, E. M., McCollister, D. D., and Irish, D. D., 1951, Vapor toxicity of ethylene dichloride determined by experiments on laboratory animals. Arch. Ind. Hyg. Occup. Med. 4:482-493.
-
(1951)
Arch. Ind. Hyg. Occup. Med.
, vol.4
, pp. 482-493
-
-
Spencer, H.C.1
Rowe, V.K.2
Adams, E.M.3
McCollister, D.D.4
Irish, D.D.5
-
110
-
-
0001553275
-
Toxicological investigation of 1,2-dibromo-3-chloropropane
-
Torkelson, T. R., Sadek, S. E., Rowe, V. K., Kodama, I. K., Anderson, H. H., Loquvam, G. S., and Hine, C. H., 1961, Toxicological investigation of 1,2-dibromo-3-chloropropane. Toxicol. Appl. Pharmacol. 3:545-553.
-
(1961)
Toxicol. Appl. Pharmacol.
, vol.3
, pp. 545-553
-
-
Torkelson, T.R.1
Sadek, S.E.2
Rowe, V.K.3
Kodama, I.K.4
Anderson, H.H.5
Loquvam, G.S.6
Hine, C.H.7
-
111
-
-
0023871572
-
Bacterial cysteine conjugate ß-lyase and the metabolism of cysteine S-conjugates: Structural requirements for the cleavage of S-conjugates and the formation of reactive intermediates
-
Vamvakas, S., Berthold, K., Dekant, W., and Henschler, D., 1988a, Bacterial cysteine conjugate ß-lyase and the metabolism of cysteine S-conjugates: Structural requirements for the cleavage of S-conjugates and the formation of reactive intermediates. Chem.-Biol. Interact. 65:59-71.
-
(1988)
Chem.-Biol. Interact.
, vol.65
, pp. 59-71
-
-
Vamvakas, S.1
Berthold, K.2
Dekant, W.3
Henschler, D.4
-
112
-
-
0023751662
-
Mutagenicity of amino acid and glutathione S-conjugates in the Ames test
-
Vamvakas, S., Elfarra, A. A., Dekant, W., Henschler, D., and Anders, M. W., 1988b, Mutagenicity of amino acid and glutathione S-conjugates in the Ames test. Mutat. Res. 206:83-90.
-
(1988)
Mutat. Res.
, vol.206
, pp. 83-90
-
-
Vamvakas, S.1
Elfarra, A.A.2
Dekant, W.3
Henschler, D.4
Anders, M.W.5
-
113
-
-
0024535906
-
Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine S-conjugates of haloalkenes and haloalkanes
-
Vamvakas, S., Dekant, W., and Henschler, D., 1989a, Assessment of unscheduled DNA synthesis in a cultured line of renal epithelial cells exposed to cysteine S-conjugates of haloalkenes and haloalkanes. Mutat. Res. 222:329-335.
-
(1989)
Mutat. Res.
, vol.222
, pp. 329-335
-
-
Vamvakas, S.1
Dekant, W.2
Henschler, D.3
-
114
-
-
0024322674
-
Metabolic activation of the nephrotoxic haloalkene 1,1,2-trichloro-3,3,3-trifluoro-1-propene by glutathione conjugation
-
Vamvakas, S., Kremling, E., and W., D., 1989b, Metabolic activation of the nephrotoxic haloalkene 1,1,2-trichloro-3,3,3-trifluoro-1-propene by glutathione conjugation. Biochem. Pharmacol. 38:2297-2304.
-
(1989)
Biochem. Pharmacol.
, vol.38
, pp. 2297-2304
-
-
Vamvakas, S.1
Kremling, E.2
W., D.3
-
115
-
-
0024625073
-
Mutagenicity of tetrachloroethylene in the Ames-test: Metabolic activation by conjugation with glutathione
-
Vamvakas, S., Herkenhoff, M., Dekant, W., and Henschler, D., 1989c, Mutagenicity of tetrachloroethylene in the Ames-test: Metabolic activation by conjugation with glutathione. J. Biochem. Toxicol. 4:21-27.
-
(1989)
J. Biochem. Toxicol.
, vol.4
, pp. 21-27
-
-
Vamvakas, S.1
Herkenhoff, M.2
Dekant, W.3
Henschler, D.4
-
116
-
-
0024309602
-
Genotoxicity of haloalkene and haloalkane glutathione S-conjugates in porcine kidney cells
-
Vamvakas, S., Dekant, W., and Henschler, D., 1989d, Genotoxicity of haloalkene and haloalkane glutathione S-conjugates in porcine kidney cells. Toxicol. in vitro 3:151-156.
-
(1989)
Toxicol. in Vitro
, vol.3
, pp. 151-156
-
-
Vamvakas, S.1
Dekant, W.2
Henschler, D.3
-
117
-
-
0024470691
-
Cytotoxicity of cysteine S-conjugates: Structure-activity relationships
-
Vamvakas, S., Köchling, A., Berthold, K., and Dekant, W., 1989e, Cytotoxicity of cysteine S-conjugates: structure-activity relationships. Chem.-Biol. Interact. 71:79-90.
-
(1989)
Chem.-Biol. Interact.
, vol.71
, pp. 79-90
-
-
Vamvakas, S.1
Köchling, A.2
Berthold, K.3
Dekant, W.4
-
118
-
-
0025092615
-
Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates
-
Vamvakas, S., Sharma, V. K., Shen, S.-S., and Anders, M. W., 1990, Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates. Molec. Pharmacol. 38:455-461.
-
(1990)
Molec. Pharmacol.
, vol.38
, pp. 455-461
-
-
Vamvakas, S.1
Sharma, V.K.2
Shen, S.-S.3
Anders, M.W.4
-
120
-
-
0027193334
-
1 cells: A comparative investigation with growth factors and 12-O-tetradecanoylphorbolacetate
-
1 cells: A comparative investigation with growth factors and 12-O-tetradecanoylphorbolacetate. Cell Biol. Toxicol. 9:1-13.
-
(1993)
Cell Biol. Toxicol.
, vol.9
, pp. 1-13
-
-
Vamvakas, S.1
Köster, U.2
-
121
-
-
0018724657
-
Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugation
-
Van Bladeren, P. J., Gen, A., Breimer, D. D., and Mohn, G. R., 1979, Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugation. Biochem. Pharmacol. 28:2521-2524.
-
(1979)
Biochem. Pharmacol.
, vol.28
, pp. 2521-2524
-
-
Van Bladeren, P.J.1
Gen, A.2
Breimer, D.D.3
Mohn, G.R.4
-
122
-
-
0019176734
-
The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane
-
Van Bladeren, P. J., Breimer, D. D., Rotteveel-Smijs, G. M. T., Jong, R. A. W., Buijs, W., Gen, A., and Mohn, G. R., 1980, The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane. Biochem. Pharmacol. 29:2975-2982.
-
(1980)
Biochem. Pharmacol.
, vol.29
, pp. 2975-2982
-
-
Van Bladeren, P.J.1
Breimer, D.D.2
Rotteveel-Smijs, G.M.T.3
Jong, R.A.W.4
Buijs, W.5
Gen, A.6
Mohn, G.R.7
-
123
-
-
0024261748
-
Features of microsomal and cytosolic glutathione conjugation of hexachlorobutadiene in rat liver
-
Wallin, A., Gerdes, R. G., Morgenstern, R., Jones, T. W., and Ormstad, K., 1988, Features of microsomal and cytosolic glutathione conjugation of hexachlorobutadiene in rat liver. Chem.-Biol. Interact. 68:1-11.
-
(1988)
Chem.-Biol. Interact.
, vol.68
, pp. 1-11
-
-
Wallin, A.1
Gerdes, R.G.2
Morgenstern, R.3
Jones, T.W.4
Ormstad, K.5
-
124
-
-
0025042850
-
Covalent interactions of 1,2,3-trichloropropane with hepatic macromolecules: Studies in the male F-344 rat
-
Weber, G. L., and Sipes, I. G., 1990, Covalent interactions of 1,2,3-trichloropropane with hepatic macromolecules: Studies in the male F-344 rat. Toxicol. Appl. Pharmacol. 104:395-402.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.104
, pp. 395-402
-
-
Weber, G.L.1
Sipes, I.G.2
-
125
-
-
0026600681
-
In vitro metabolism and bioactivation of 1,2,3-trichloropropane
-
Weber, G. L., and Sipes, I. G., 1992, In vitro metabolism and bioactivation of 1,2,3-trichloropropane. Toxicol. Appl. Pharmacol. 113:152-158.
-
(1992)
Toxicol. Appl. Pharmacol.
, vol.113
, pp. 152-158
-
-
Weber, G.L.1
Sipes, I.G.2
-
126
-
-
0017621612
-
Carcinogenicity studies on halogenated hydrocarbons
-
Weisburger, E. K., 1977, Carcinogenicity studies on halogenated hydrocarbons. Environ. Health Perspect. 21:7-16.
-
(1977)
Environ. Health Perspect.
, vol.21
, pp. 7-16
-
-
Weisburger, E.K.1
-
128
-
-
0021364090
-
Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity
-
Wolf, C. R., Berry, P. N., Nash, J. A., Green, T., and Lock, E. A., 1984, Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity. J. Pharmacol. Exp. Ther. 228:202-208.
-
(1984)
J. Pharmacol. Exp. Ther.
, vol.228
, pp. 202-208
-
-
Wolf, C.R.1
Berry, P.N.2
Nash, J.A.3
Green, T.4
Lock, E.A.5
-
129
-
-
0026768092
-
Dihydroxylated mercapturic acid metabolites of bromobenzene
-
Zheng, J., and Hanzlik, R. P., 1992, Dihydroxylated mercapturic acid metabolites of bromobenzene. Chem. Res. Toxicol. 5:561-567.
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 561-567
-
-
Zheng, J.1
Hanzlik, R.P.2
|