C-terminal heparin-binding domain of fibronectin regulates integrin-mediated cell spreading but not the activation of mitogen-activated protein kinase

Biochemical Journal

Volumn 360, Issue 1, 2001, Pages 239-245

  Kim, J ^a   Han, I ^a   Kim, Y ^a   Kim, S ^a   Oh, E S ^a  

^a Ewha Womans University   (South Korea)

Author keywords

Fibronectin; Focal adhesion kinase; Syndecan 4; Tyrosine phosphorylation

Indexed keywords

ACTIVATION ANALYSIS; ADHESION; ENZYMES; FIBERS;

CELL SPREADING;

CELLS;

EPIDERMAL GROWTH FACTOR; FIBRONECTIN; HEPARIN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTYROSINE; PLATELET DERIVED GROWTH FACTOR; SYNDECAN; TYROSINE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL SPREADING; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; CYTOSKELETON; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; FIBROBLASTS; FIBRONECTINS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GROWTH SUBSTANCES; HEPARIN; HUMANS; INTEGRINS; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTEOGLYCANS; RATS; SIGNAL TRANSDUCTION; SYNDECAN-4; TIME FACTORS; TRANSFECTION; TYROSINE;

ANIMALIA;

EID: 0035890662     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3600239     Document Type: Article

References (23)

1. Integrin signaling
2. Integrin transmembrane signaling and cytoskeletal control
3. Integrin signalling and tyrosine phosphorylation: Just the FAKs?
4. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase
5. Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly
6. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
7. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases
8. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein
9. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
10. The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes
11. Control of morphology, cytoskeleton and migration by syndecan-4
12. Syndecan-regulated receptor signaling
13. A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation
14. Syndecan 4 heparan sulfate proteoglycan is a selectively enriched and widespread focal adhesion component
15. Heparan sulfate chains from glypican and syndecans bind the Hep II domain of fibronectin similarly despite minor structural differences
16. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers
17. Focal adhesions - The cytoskeletal connection
18. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins
19. Integrin-mediated activation of MAP kinase is independent of FAK: Evidence for dual integrin signaling pathways in fibroblasts
20. Rat embryo fibroblasts require both the cell-binding and the heparin-binding domains of fibronectin for survival
21. Integrin-dependent activation of MAP kinase: A link to shape-dependent cell proliferation
22. FAK integrates growth factor and integrin signals to promote cell migration
23. Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase