Restoration of glutathione levels in vascular smooth muscle cells exposed to high glucose conditions

Free Radical Biology and Medicine

Volumn 31, Issue 10, 2001, Pages 1149-1155

  Powell, Lesley A ^a,b   Nally, Sinead M ^b   McMaster, Dorothy ^b   Catherwood, Mark A ^b   Trimble, Elisabeth R ^a,b  

^a ROYAL GROUP OF HOSPITALS   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Lipoic acid; Glutamylcysteine synthetase; Cyst(e)ine; DNA damage; Free radicals; Glutathione; High glucose; Vascular smooth muscle cells

Indexed keywords

ANTIOXIDANT; BUTHIONINE SULFOXIMINE; CYSTEINE; DNA; ENZYME INHIBITOR; GLUCOSE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; MESSENGER RNA; THIOCTIC ACID;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME SUBSTRATE; ENZYME SUBUNIT; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

AORTA; BUTHIONINE SULFOXIMINE; CELLS, CULTURED; CYSTEINE; DNA DAMAGE; GLUCOSE; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; MUSCLE, SMOOTH, VASCULAR; RNA, MESSENGER; THIOCTIC ACID;

EID: 0035890122     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00648-7     Document Type: Article

References (45)

1. Blood glutathione in mild diabetes before treatment and during sulphonylurea-induced hypoglycemia
2. Blood-reduced glutathione, serum ceruloplasmin and mineral changes in juvenile diabetes
3. Glutathione and its redox system in diabetic polymorphonuclear leukocytes
4. Platelet glutathione and thromboxane synthesis in diabetes
5. Effect of insulin on impaired antioxidant activities in aortic endothelial cells from diabetic rabbits
6. Antioxidant and redox regulation of gene transcription
7. Optimal NF-κB-mediated transcriptional responses in Jurkat cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals
8. Gene expression and the thiol redox state
9. Regulation of γ-glutamylcysteine synthetase by nonallosteric feedback inhibition by glutathione
10. Reversible dissociation of γ-GCS into two subunits
11. Amino acid sequence and function of the light subunit of rat kidney γ-GCS
12. Cloning and sequencing of the cDNA for the light subunit of human liver γ-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues
13. Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus
14. Long exposure to high glucose concentration impairs the responsive expression of γ-GCS by interleukin-1β and tumor necrosis factor-α in mouse endothethial cells
15. Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: Regulation of glutathione synthesis and efflux
16. The effects of glucose-induced oxidative stress on growth and extracellular matrix gene expression of vascular smooth muscle cells
17. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
18. A simple technique for quantification of low levels of DNA damage in individual cells
19. Comet assay to detect nitric oxide dependent DNA damage in mammalian cells
20. Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin-2-induced transcript in a cloned T-helper lymphocyte
21. Cloning and nucleotide sequence of a full-length cDNA for human liver γ-glutamylcysteine synthetase
22. Single-step method of RNA isolation by acid guanidinium thiocyanate phenol-chloroform extraction
23. Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization
24. Influence of α-lipoic acid on intracellular glutathione in vitro and in vivo
25. High concentration of glucose causes impairment of the function of glutathione redox cycle in human vascular smooth muscle cells
26. Role of membrane transport in metabolism and function of glutathione in mammals
27. - and maintenance of intracellular glutathione levels in pancreatic acinar and islet cell lines
28. Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia
29. Cystine uptake and glutathione levels in endothelial cells exposed to oxidative stress
30. Induction of cystine transport activity in mouse peritoneal macrophages
31. Maintenance of neuronal glutathione by glial cells
32. A role for γ-glutamylpeptidase in the transport of cystine into human endothelial cells: Relationship to intracellular glutathione
33. Biologic and pharmacologic regulation of mammalian glutathione synthesis
34. Constitutive and β-naphthoflavone-induced expression of the human γ-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence
35. Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches
36. Regulation of γ-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2
37. High glucose elevates c-fos and c-jun transcripts and proteins in mesangial cell cultures
38. Ozone-induced alterations in glutathione in lung subcompartments of rats and monkeys
39. Gamma-glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal
40. Antioxidant enzyme regulation and resistance to oxidants of human bronchial epithelial cells cultured under hypoxic conditions
41. Cysteine regulates expression of cysteine dioxygenase and γ-glutamylcysteine synthetase in cultured rat hepatocytes
42. Overexpression of the regulatory subunit of γ-glutamylcysteine synthetase in HeLa cells increases glutamylcysteine synthetase activity and confers drug resistance
43. Transfection of complementary DNAs for heavy and light subunits of human γ-glutamylcysteine synthetase results in an elevation of intracellular glutathione and resistance to melphalan
44. Increased transcription of the regulatory subunit of γ-glutamylcysteine synthetase in rat lung epithelial L2 cells exposed to oxidative stress or glutathione depletion
45. Differential regulation of γ-glutamylcysteine synthetase heavy and light subunit gene expression