Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: Analysis of data from the third National Health and Nutrition Examination Survey

Blood

Volumn 98, Issue 8, 2001, Pages 2345-2351

  McLaren, Christine E ^a,b,c,d,e   Li, Kuo Tung ^a,b,c,d,e   Gordeuk, Victor R ^a,b,c,d,e   Hasselblad, Victor ^a,b,c,d,e   McLaren, Gordon D ^a,b,c,d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD UNIVERSITY   (United States)

^d DUKE UNIVERSITY   (United States)

^e VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; IRON DERIVATIVE; TRANSFERRIN;

ADULT; ARTICLE; CAUCASIAN; CIRCADIAN RHYTHM; DATA ANALYSIS; FEMALE; FERRITIN BLOOD LEVEL; GENE LOCUS; HEALTH SURVEY; HUMAN; IRON STORAGE; MAJOR CLINICAL STUDY; MALE; NEGRO; POPULATION GENETICS; POPULATION RESEARCH; PRIORITY JOURNAL; RACE DIFFERENCE; STATISTICAL ANALYSIS; STATISTICAL MODEL; UNITED STATES;

EID: 0035889141     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.8.2345     Document Type: Article

References (50)

1. Gordeuk VR, McLaren, CE, Looker AC, Hasselblad V, Brittenham GM. Distribution of transferrin saturations in the African-American population. Blood. 1998;91:2175-2179.
2. McLaren CE, Gordeuk VR, Looker AC, et al. Prevalence of heterozygotes for hemochromatosis in the white population of the United States. Blood. 1995;86:2021-2027.
3. Jandl JH. Blood. Boston: Little, Brown; 1987.
4. Edwards CQ, Griffen LM, Goldgar D, et al. Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N Engl J Med. 1988;318:1355-1362.
5. Looker AC, Johnson CL. Prevalence of elevated serum transferrin saturation in adults in the United States. Ann Intern Med. 1998;129:940-945.
6. Plan and operation of the Third National Health and Nutrition Examination Survey, 1988-94. DHHS publication no. (PHS) 94-1308, (Vital and Health Statistics; series 1; no. 32). Hyattsville, MD: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for Health Statistics; 1994
7. Gunter EW, Lewis BL, Koncikowski SM. Laboratory procedures used for the third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 [CD-ROM]. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Center for Environmental Health, and Hyattsville, MD: National Center for Health Statistics; 1996. Available from National Technical Information Service, Springfield, VA.
8. Finch CA, Deubelbeiss K, Cook JD, et al. Ferrokinetics in man. Medicine. 1970;49:17-53.
9. Hershko C, Graham G, Bates GW, Rachmilewitz EA. Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity. Br J Haematol. 1978;40:255-263.
10. Cartwright GE, Wintrobe MM. Chemical, clinical, and immunological studies on the products of human plasma fractionation; XXXIX, the anemia of infection. Studies on the iron-binding capacity of serum. J Clin Invest. 1949;28:86-98.
11. Bainton DF, Finch CA. The diagnosis of iron deficiency anemia. Am J Med. 1964;37:62-70.
12. Edwards CQ, Griffen LM, Kaplan J, Kushner JP. Twenty-four hour variation of transferrin saturation in treated and untreated hemochromatosis homozygotes. J Intern Med. 1989;226:173-179.
13. Gordeuk VR, Brittenham GM, McLaren GD Spagnuolo PJ. Hyperferremia in immmunosuppressed patients with acute nonlymphocytic leukemia and the risk of infection. J Lab Clin Med. 1986;108:466-472.
14. Barton JC, Bertoli LF, Rothenberg BE. Peripheral blood erythrocyte parameters in hemochromatosis: evidence for increased erythrocyte hemoglobin content. J Lab Clin Med 2000;135:96-104.
15. Cartwright GE, Hugeley CM, Ashenbrucker H, et al. Studies on free erythrocyte protoporphyrin, plasma iron and plasma copper in normal and anemic subjects. Blood. 1948;3:501-525.
16. Devasthali SD, Gordeuk VR, Brittenham GM, et al. Bioavailability of carbonyl iron: a randomized, double-blind study. Eur J Haematol. 1991;46:272-278.
17. Bell H, Skinningsrud A, Raknerud N, Try K. Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases. J Intern Med. 1994;236:315-322.
18. Brendstrup P. Serum copper, serum iron and total iron binding capacity of serum in patients with chronic rheumatoid arthritis. Acta Med Scand. 1953;146:384-392.
19. Cartwright GE. The anemia of chronic disorders. Semin Haematol. 1966;3:351-375.
20. Hamilton LD, Gubler CJ, Cartwright GE,Wintrobe MM. Diurnal variation in the plasma iron level of man. Proc Soc Exp Biol Med. 1950;75:65-68.
21. Chakraborty R, Kamboh MI, Nwankwo M, Ferrell RE. Caucasian genes in American blacks. New data. Am J Hum Genet. 1992;50:145-155.
22. Beutler E, Felitti V, Gelbart T, Ho N. The effect of HFE genotypes on measurements of iron overload in patients attending a health appraisal clinic. Ann Intern Med 2000;133:329-337.
23. Barton JC, Acton RT. Transferrin saturation phemotype and HFEgenotype screening for hemochromatosis and primary iron overload: predictions from a model based on national, racial, and ethnic group composition in central Alabama. Genet Test. 2000;4:199-206.
24. McLaren CE, McLachlan GJ, Halliday JW, et al. Distribution of transferrin saturation in an Australian population: relevance to the early diagnosis of hemochromatosis. Gastroenterology. 1998;114:543-549.
25. Hasselblad V. Manual for the grouped DISFIT software. Version 1.1. Durham, NC: Duke University; 1992.
26. McLaren CE, Brittenham GM, Hasselblad V. Analysis of the volume of red blood cells: application of the expectation-maximization algorithm to grouped data from the doubly-truncated lognormal distribution. Biometrics. 1986;42:143-158.
27. McLaren CE, Brittenham GM, Hasselblad V. Statistical and graphical evaluation of erythrocyte volume distributions. Am J Physiol. 1987;252:H857-H866.
28. McLachlan GJ, Basford KE. Mixture models: inference and applications to clustering. New York, NY: Marcel Dekker; 1988.
29. Crump KS, Howe R. A preview of methods for calculating confidence limits in low dose extrapolation. In: Clayton DB, Krewski D, Munro IC, eds. Toxicological risk assessment. Boca Raton, FL: CRC Press; 1985.
30. Expert Scientific Working Group. Summary of a report on assessment of the iron nutritional status of the United States population. Am J Clin Nutr. 1985;42:1318-1330.
31. Milman N. Serum ferritin in Danes: studies of iron status from infancy to old age, during blood donation and pregnancy. Int J Hematol. 1996;63:103-135.
32. McCord JM, Iron, free radicals, and oxidative injury. Semin Hematol. 1998;35:5-12.
33. Cook JD, Finch CA, Smith NJ. Evaluation of the iron status of a population. Blood. 1976;48:449-455.
34. Leggett BA, Brown NN, Bryant SJ, et al, Factors affecting the concentrations of ferritin in serum in a healthy Australian population. Clin Chem. 1990;36:1350-1355.
35. Custer EM, Finch CA, Sobel RE, et al. Population norms for serum ferritin. J Lab Clin Med. 1995;126:88-94.
36. Pilch SM, Senti FR. Assessment of the iron nutritional status of the US population based on data collected in the Second National Health and Nutrition Examination Survey, 1976-80. Bethesda, MD: Life Sciences Research Office, Federation of American Societies for Experimental Biology; August 1984.
37. Zacharski LR, Ornstein DL, Woloshin S, Schwartz LM. Association of age, sex, and race with body iron stores in adults: analysis of NHANES III data. Am Heart J. 2000;140:98-104.
38. Cuzick, Jack. Trend tests. In: Kotz S, Johnson N, eds. Encyclopedia of Statistical Sciences. Vol 9. New York, NY: John Wiley; 1988:336-342.
39. Mohadjer L, Montaquila J, Waksberg J, et al. National Health and Nutrition Examination Survey III. Weighting and Estimation Methodology. Rockville, MD: MID: WESTAT; 1996.
40. Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated n patients with hereditary haemochromatosis. Nat Genet. 1996;13:399-408.
41. Gordeuk VR, Mukiibi J, Hasstedt SJ, et al. Iron overload in Africa: interaction between and gene and dietary iron content. N Engl J Med. 1992;326:95-100.
42. McNamara L, MacPhail AP, Gordeuk VR, Hasstedt SJ, Rouault T. Is there a link between Afrian iron overload and the described mutations of the hereditary haemochromatosis gene? Br J Haematol. 1998;102:1176-1178.
43. Lucotte G, Mercier G. Celtic origin of the C282Y mutation of hemochromatosis. Genet Test. 2000;4:163-169.
44. Burt MJ, George PM, Upton JD, et al. The significance of haemochromatosis gene mutations in the general population: implications for screening. Gut. 1998;43:830-836.
45. Guttridge MG, Carter K, Worwood M, Darke C. Population screening for hemochromatosis by PCR using sequence-specific primers. Genet Test. 2000;4:111-114.
46. Rossi E, Olynyk JK, Cullen DJ, et al. Compound heterozygous hemochromatosis genotype predicts increased iron and erythrocyte indices in women. Clin Chem. 2000;46:162-166.
47. Adams PC, Kertesz AE, McLaren CE, Barr R, Bamford A, Chakrabarti S. Population screening for hemochromatosis: a comparison of unbound iron-binding capacity, transferrin saturation, and C282Y genotyping in 5,211 voluntary blood donors. Hepatology. 2000;31:1160-1164.
48. Beaumont C, Simon M, Fauchet R, et al. Serum ferritin as a possible marker of the hemochromatosis allele. N Engl J Med. 1979;301:169-174.
49. Dadone MM, Kushner JP, Edwards CQ, et al. Hereditary hemochromatosis: analysis of laboratory expression of the disease by genotype in 18 pedigrees. Am J Clin Pathol. 1982;78:196-207.
50. Edwards CQ, Kushner JP. Screening for hemochromatosis. N Engl J Med. 1993;328:1616-1620.