Apoptosis-inducing human-origin Fcε-Bak chimeric proteins for targeted elimination of mast cells and basophils: A new approach for allergy treatment

Journal of Immunology

Volumn 167, Issue 8, 2001, Pages 4719-4728

  Belostotsky, R ^a   Lorberboum Galski, H ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; BETA N ACETYLHEXOSAMINIDASE; CHIMERIC PROTEIN; DNA; FC RECEPTOR; IMMUNOGLOBULIN FC FRAGMENT; PROTEIN BAK; PROTEIN BAX; RNA;

ALLERGIC DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BASOPHIL DEGRANULATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; INTERNALIZATION; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 0035887634     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.8.4719     Document Type: Article

References (34)

1. Immunotoxins against cancer
2. Targeted elimination of cells expressing the high-affinity receptor for IgE (FcεRI) by a Pseudomonas exotoxin-based chimeric protein
3. Targeted Fc2′-3-PE40 chimeric protein abolishes passive cutaneous anaphylaxis in mice
4. Bcl-2 and Bax function independently to regulate cell death
5. Induction of apoptosis by the Bcl-2 homologue Bak
6. Interleukin 2-Bax: A novel prototype of human chimeric proteins for targeted therapy
7. Human Bak induces cell death in Schizosaccharomyces pombe with morphological changes similar to those with apoptosis in mammalian cells
8. L-Bak peptide complex: Recognition between regulators of apoptosis
9. GnRH-Bik/Bax/Bak chimeric proteins target and kill adenocarcinoma cells: The general use of pro-apoptotic proteins of the Bcl-2 family as novel killing components of targeting chimeric proteins
10. Mast cell clones: A model for the analysis of cellular maturation
11. Isolation and characterization of Abelson murine leukemia virus- transformed must cell lines from midgestation embryonic placenta
12. Identification, purification, and characterization of a mast cell-associated cytolytic factor related to tumor necrosis factor
13. A new leukemia cell line with Philadelphia chromosome characterized as basophil precursors
14. Characterization of a human basophil-like cell line (LAMA-84)
15. Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3
16. Adenocarcinoma cells are targeted by the new GnRH-PE66 chimeric toxin through specific gonadotropin-releasing hormone binding sites
17. Immunologic release of β-hexosaminidase and β-glucuronidase from purified rat serosal mast cells
18. Bacterial toxins: Cellular mechanisms of action
19. Susceptibility to apoptosis is restored in human leukemia HCW-2 cells following induction and stabilization of the apoptotic effector Bak
20. Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)
21. Blocking of passive sensitization of human mast cells and basophil granulocytes with IgE antibodies by a recombinant human ε-chain fragment of 76 amino acids
22. Conformation of the isolated cε3 domain of IgE and its complex with the high-affinity receptor
23. The immunoglobulin-like modules Cε3 and α2 are the minimal units necessary for human IgE-FcεRI interaction
24. Purification and characterization of human recombinant IgE-Fc fragments that bind to the human high affinity IgE receptor
25. L function and induce apoptosis through cytochrome c-independent activation of caspases
26. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
27. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions
28. The mast cell and mast cell disease
29. Mast cells in infection and immunity
30. Does IgE bind to and activate eosinophils from patients with allergy?
31. Intracellular expression and release of FcεRIα by human eosinophils
32. Blood eosinophils from atopic donors express messenger RNA for the α, β, and γ subunits of the high-affinity IgE receptor (FcεRI) and intracellular, but not cell surface, α subunit protein
33. Expression and functions of the high-affinity IgE receptor on human platelets and megakaryocyte precursors
34. The high-affinity IgE receptor (FcεRI): From physiology to pathology