Characterization of the functional heterologous desensitization of hypothalamic 5-HT1A receptors after 5-HT2A receptor activation

Journal of Neuroscience

Volumn 21, Issue 20, 2001, Pages 7919-7927

  Zhang, Yahong ^a   D'Souza, Deborah ^a   Raap, Daní K ^a   Garcia, Francisca ^a   Battaglia, George ^a   Muma, Nancy A ^a   Van De Kar, Louis D ^a,b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

ACTH; Gz protein; GTP S; Neuroendocrine; Oxytocin; Serotonin; 3H 8 OH DPAT binding

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ANTIDEPRESSANT AGENT; CORTICOTROPIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; OXYTOCIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHRONOTHERAPY; CONTROLLED STUDY; DEPRESSION; DESENSITIZATION; DOSE TIME EFFECT RELATION; DRUG BINDING; DRUG MECHANISM; DRUG POTENTIATION; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 0035887628     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-20-07919.2001     Document Type: Article

References (60)

1. 1A receptor: Signaling, desensitization, and gene transcription
2. 1c receptors in rat brain
3. 2c receptor-mediated oxytocin, prolactin, and ACTH/corticosterone responses
4. 1c receptors induce oxytocin release in the male rat
5. 2 receptor agonist-induced oxytocin, prolactin, and corticosterone responses
6. z
7. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
8. 1A-receptor agonist-induced corticotropin and cortisol responses after long-term ipsapirone and fluoxetine administration to healthy subjects
9. Chronic administration of serotonergic antidepressants attenuates the subjective effects of LSD in humans
10. 1A receptor-mediated feedback: A microdialysis study in the amygdala
11. 1A receptor in Sf9 cells. Reconstitution of a coupled phenotype by coexpression of mammalian G-protein subunits
12. G-protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications
13. 1A receptor antagonist WAY100635
14. 2 receptors?
15. 2c receptor agonist, RO 600175: A pharmacological analysis
16. 1A receptor by phospholipid-derived signaling components
17. zα by protein kinase C blocks interaction with the βγ complex
18. Desensitization of G-protein-coupled receptors
19. 2A receptor in rat C6 glioma cells
20. zα
21. 2c receptors revealed by heterologous expression
22. Ovarian steroid effects on serotonin 1A, 2A, and 2C receptor mRNA in macaque hypothalamus
23. z is correlated with an inhibition of palmitoylation and membrane attachment, but has no effect on phosphorylation by protein kinase C
24. 1A receptor sensitivity
25. 1c receptors
26. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
27. 2A receptor ligand
28. Protein kinase C phosphorylates the inhibitory guanine nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase
29. Excitation of hypothalamic paraventricular neurons by stimulation of the raphe nuclei
30. Pre-clinical characterization of the potential of the putative atypical anti-psychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile
31. 2 receptors in rats
32. Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (±)-l-(2,5 -dimethoxy-4-iodophenyl)-2-aminopropane HCI (DOI)
33. 1A agonist
34. 1A receptors
35. Synaptic interaction of serotonergic axons and corticotropin-releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the ra. A light and electron microscopic immunocytochemical study
36. Modulation of the behavioral effects of 8-OH-DPAT by estrogen and DOI
37. 1A receptor-mediated regulation of plasma neuroendocrine hormones
38. z requires two signals
39. 1A receptor and its ligands: Structure and function
40. Selective serotonin reuptake inhibitors and neuroendocrine function
41. i proteins
42. Possible role of protein kinase C in regulation of 5-hydroxytryptamine 2A receptors in rat brain
43. 1A receptor
44. 2A/2c) receptors
45. Paraventricular nucleus magnocellular neuronal responses following electrical stimulation of the midbrain dorsal raphe
46. 11C] WAY100635: Effects of depression and antidepressant treatment
47. Localization, colocalization, and plasticity of corticotropin-releasing factor immunoreactivity in rat brain
48. 1A receptors in vivo
49. 20 receptor
50. Imaging of the serotonergic system: Interactions of neuroanatomical and functional abnormalities of depression
51. Serotonin receptors in suicide victims with major depression
52. 2 receptor-mediated c-fos gene expression
53. Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line: Involvement of arachidonic acid metabolism
54. Hypothalamic paraventricular, but not supraoptic, neurons mediate the serotonergic stimulation of oxytocin secretion
55. 2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells
56. WAYI00635 inhibits 8-OH-DPAT stimulated oxytocin, ACTH, and corticosterone, but not prolactin secretion
57. Central 5-hydroxytryptamine receptor-linked protein kinase C translocation: A functional postsynaptic signal transduction system
58. z GTPase-activating protein subfamily
59. 2 receptor subtype mRNAs in rat brain