The role of CYP forms in the metabolism and metabolic activation of HCFCs and other halocarbons

Toxicology Letters

Volumn 124, Issue 1-3, 2001, Pages 121-128

  White, Ian N H ^a   Matteis, Francesco De ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Cytochrome P450; Hydrochlorofluorocarbons 123; Neoantigens; Perchloroethylene

Indexed keywords

1,1 DICHLORO 1 FLUOROETHANE; 1,1 DICHLORO 2,2,2 TRIFLUOROETHANE; CHLOROFLUOROCARBON; CHLOROFLUOROHYDROCARBON; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 ISOENZYME; HALOCARBON; LYSINE; NITRITE; TETRACHLOROETHYLENE; TRICHLOROACETYL CHLORIDE; TRIFLUOROACETYL CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYST; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; LIVER CELL CARCINOMA; LIVER TOXICITY; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OZONE LAYER; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CATALYSIS; CHLOROFLUOROCARBONS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; KIDNEY NEOPLASMS; KIDNEY TUBULES; LIVER NEOPLASMS; MICE; OXIDATION-REDUCTION; RATS;

EID: 0035887407     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(00)00288-5     Document Type: Article

References (50)

1. Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes
2. Metabolism and toxicity of hydrochlorofluorocarbons: Current knowledge and needs for the future
3. Biodegradation and ecotoxicity of HFCs and HCFCs
4. Generation and detection of neoantigens in guinea pig liver slices incubated with halothane
5. Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis
6. Halothane metabolism: Immunochemical evidence for molecular mimicry of trifluoroacetylated liver protein adducts by constitutive polypeptides
7. Tetrachloroethylene metabolism by the hepatic microsomal cytochrome P-450 system
8. The role of cytochrome P450 2E1 in the species-dependent biotransformation of 1,2-dichloro-1,1,2-trifluoroethane in rats and mice
9. Bioactivation of tetrachloroethylene
10. Bioactivation of tetrachloroethylene. Role of glutathione S-transferase-catalyzed conjugation versus cytochrome P-450-dependent phospholipid alkylation
11. Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: Bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity
12. Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis
13. Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis
14. Activation of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) by rat liver microsomes and isolated hepatocytes
15. Cytochrome P450 inactivation during reductive metabolism of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) by phenobarbital-and pyridine-induced rat liver microsomes
16. Model calculations of the relative effects of CFCs and their replacements on global warming
17. The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis
18. Activation by human CYP isoenzymes of chlorofluorohydrocarbons that results in clastogenicity and protein binding
19. Conditions influencing the rat liver microsomal metabolism of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)
20. Interaction of tetrachloroethylene with rat hepatic microsomal P450-dependent monooxygenases
21. Metabolic activation of halothane to neoantigens in C57/Bl/10 mice: Immunochemical studies
22. Epidemic of liver disease caused by hydrochloro fluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons
23. Factors affecting the expression of trifluoroacetylated liver microsomal protein neoantigens in rats treated with halothane
24. Metabolic basis for a drug hypersensitivity: Antibodies in sera from patients with halothane hepatitis recognize liver neoantigens that contain the trifluoroacetyl group derived from halothane
25. Detection of autoantibodies directed against human hepatic endoplasmic reticulum in sera from patients with halothane-associated hepatitis
26. Free radical metabolism of halothane in vivo: Radical adducts detected in bile
27. Time course of 72-kilodalton heat shock protein induction and appearance of trifluoroacetyl adducts in livers of halothane-exposed rats
28. A metabolite of halothane covalently binds to an endoplasmic reticulum protein that is highly homologous to phosphatidylinositol-specific phospholipase C-alpha but has no activity
29. Evidence of DNA binding activity of perchloroethylene
30. Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosis
31. Halothane anaesthesia and liver damage
32. Halothane hepatitis
33. Biotransformation of halothane, enflurane, isoflurane, and desflurane to trifluoroacetylated liver proteins: Association between protein acylation and hepatic injury
34. Generation of antibodies to di- and trichloroacetylated proteins and immunochemical detection of protein adducts in rats treated with perchloroethene
35. The immunologic and metabolic basis of drug hypersensitivities
36. Hapten carrier conjugates associated with halothane hepatitis
37. The formation of neoantigens and the clastogenic action of certain hydrochloroflurocarbons in human MCL-5 cells
38. Subchronic inhalation toxicity studies with hydrochlorofluorocarbon 123 (HCFC 123)
39. Immunochemical evidence of trifluoroacetylated cytochrome P-450 in the liver of halothane-treated rats
40. Human anti-endoplasmic reticulum antibodies in sera of patients with halothane-induced hepatitis are directed against a trifluoroacetylated carboxylesterase
41. Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis
42. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme
43. Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450
44. Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium
45. Metabolism of 1,1-dichloro-2,2,2-trifluoroethane in rats
46. Dose-dependent metabolism of 2,2-dichloro-1,1,1-trifluoroethane: A physiologically based pharmacokinetic model in the male Fischer 344 rat
47. Biotransformation of perchloroethene: Dose-dependent excretion of trichloroacetic acid, dichloroacetic acid and N-acetyl-S-(trichlorovinyl)-L-cysteine in rats and humans after inhalation
48. Neoantigen formation and clastogenic action of HCFC-123 and perchloroethylene in human MCL-5 cells
49. Halothane-induced cytotoxicity to rat centrilobular hepatocytes in primary culture is not increased under low oxygen concentration