Radiation-induced hypoxia may perpetuate late normal tissue injury

International Journal of Radiation Oncology Biology Physics

Volumn 50, Issue 4, 2001, Pages 851-855

  Vujaskovic, Zeljko ^a   Anscher, Mitchell S ^a   Feng, Qin Fu ^a   Rabbani, Zahid N ^a   Amin, Khalid ^a   Samulski, Thaddeus S ^a   Dewhirst, Mark W ^a   Haroon, Zishan A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hypoxia; Lung; Radiation injury

Indexed keywords

COLLAGEN; DEPOSITION; HISTOLOGY; IRRADIATION; PATHOLOGY; RADIATION; TISSUE;

HYPOXIA; PULMONARY FUNCTIONS;

ONCOLOGY;

CD31 ANTIGEN; COLLAGEN; CYTOKINE; ENDOTHELIN 1; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING RATE; CONTROLLED STUDY; FEMALE; HYPOXIA; IMMUNOHISTOCHEMISTRY; IRRADIATION; LUNG FIBROSIS; LUNG FUNCTION; LUNG INJURY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RAT;

ANIMALS; CELL HYPOXIA; ENDOTHELIAL GROWTH FACTORS; FEMALE; FIBROSIS; LUNG; LYMPHOKINES; MACROPHAGES; RADIATION INJURIES, EXPERIMENTAL; RADIATION TOLERANCE; RATS; RATS, INBRED F344; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035879438     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(01)01593-0     Document Type: Article

References (15)

1. The physical parameters and molecular events associated with radiation-induced lung toxicity
2. Effects of radiation on normal tissue; Hypothetical mechanism and limitations of in situ assays of clonogenicity
3. A perpetual cascade of cytokines post irradiation leads to pulmonary fibrosis
4. Angiogenesis, and oxygen transport in solid tumors
5. Hypoxia regulatory elements of the human vascular endothelial growth factor gene
6. Oxygen regulation of TGF-beta 1 mRNA in human hepatoma (Hep G2) cells
7. Radiological and functional assessment of radiation-induced lung injury in the rat
8. The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics
9. Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and 'non-fibrosing' mice during the latent period and early phase after irradiation
10. A reduction in the in situ rates of oxygen and glucose consumption of cells in EMT6/Ro spheroids during growth
11. Early wound healing exhibits cytokine surge without evidance of hypoxia
12. Cyclosporin. A increases hypoxia and free radical production in rat kidneys; Prevention by dietary glycine
13. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis