A Point Mutation in the Juxtamembrane Stalk of Human Angiotensin I-converting Enzyme Invokes the Action of a Distinct Secretase

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21105-21109

  Alfalah, Marwan ^a   Parkin, Edward T ^b   Jacob, Ralf ^a   Sturrock, Edward D ^c   Mentele, Reinhard ^d   Turner, Anthony J ^b   Hooper, Nigel M ^b   Naim, Hassan Y ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; ENZYMES; MASS SPECTROMETRY; MUTAGENESIS;

ENDOPLASMIC RETICULUM;

BIOCHEMISTRY;

1,3 DICHLOROISOCOUMARIN; ASPARAGINE; BATIMASTAT; COUMARIN DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE; GLUTAMINE; SERINE; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; DRUG DERIVATIVE; HYBRID PROTEIN; PHENYLALANINE; PROTEINASE; PROTEINASE INHIBITOR; SECRETASE; THIOPHENE DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL BOND; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MUTATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL LINE; CELL MEMBRANE; CHEMISTRY; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; NERVE CELL; NEUROBLASTOMA; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; ENDOPEPTIDASES; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROBLASTOMA; NEURONS; PEPTIDYL-DIPEPTIDASE A; PHENYLALANINE; POINT MUTATION; PROTEASE INHIBITORS; RECOMBINANT FUSION PROTEINS; THIOPHENES; TRANSFECTION;

EID: 0035877683     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100339200     Document Type: Article

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