Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus

British Journal of Cancer

Volumn 84, Issue 12, 2001, Pages 1630-1634

  Snaddon, J ^a   Parkinson, E K ^b   Craft, J A ^a   Bartholomew, C ^a   Fulton, R ^a  

^a GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Carcinoma; LOH; P13K; PTEN

Indexed keywords

PHOSPHATASE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; CHROMOSOME 10Q; CONTROLLED STUDY; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE LOCUS; HEAD CANCER; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; NECK CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CHROMOSOMES, HUMAN, PAIR 3; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HEAD AND NECK NEOPLASMS; HUMANS; LOSS OF HETEROZYGOSITY; PHOSPHATIDATE PHOSPHATASE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN KINASES; PTEN PHOSPHOHYDROLASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 0035875576     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1848     Document Type: Article

References (22)

1. Mutational spectra of PTEN/MMACI gene: A tumor suppressor with lipid phosphatase activity
2. Deletion of chromosome 10q-a marker for metastasis of head and neck carcinomas?
3. Mutaton analysis of the putative tumour supressor gene PTEN/MMACI in primary breast carcinomas
4. Homozygous deletion of the PTEN tumor suppressor gene is not a feature in oral squamous cell carcinoma
5. Cellular immortality: A late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss
6. Lack of somatic mutation in the PTEN gene in squamous cell carcinoma of human skin
7. P13CA as an oncogene in cervical cancer
8. The tumour suppressor. PTEN/MMACI, dephosphoryrlates the lipid second messenger, phosphatidylinositol 3.4, 5-trisphosphate
9. PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
10. Analysis of PTEN/MMACI alterations in aerodigestive tract tumours
11. Basal cell carcinomas and squamous cell carcinomas of human skin show a distinct pattern of chromosome loss
12. Mutation analysis of the putative tumor suppressor gene PTEN/MMACI in primary breast carcinomas
13. Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous-cell carcinomas
14. PTEN/MMACI mutations in endometrial cancers
15. Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma
16. Comparative genomic hybridisation detects novel deletions and amplifications in head and neck squamous cell carcinomas
17. The PTEN tumour suppressor protein: An antagonist of phosphoinositide signalling
18. Inactivation of the tumor suppressor PTEN/MMACI in advanced human prostate cancer through loss of expression
19. Wild-type p53 induces apoptosis in pigmented melanoma cell lines SK-mel-23 and 70W without altering p21 (Waf1), Bcl-2 and Bax expression