Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence

Free Radical Biology and Medicine

Volumn 30, Issue 10, 2001, Pages 1130-1136

  Mori, Masayuki ^a   Toyokuni, Shinya ^b   Kondo, Shohei ^b   Kasai, Hiroshi ^c   Naiki, Hironobu ^d   Toichi, Eiko ^b   Hosokawa, Masanori ^e   Higuchi, Keiichi ^a  

^a Res Ctr Aging Adaptation   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d UNIVERSITY OF FUKUI   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

8 Oxoguanine; Free radicals; Mutation; OGG1; Oxidative DNA damage; Senescence

Indexed keywords

8 HYDROXYGUANINE; 8 OXOGUANOSINE DNA GLYCOSYLASE; CELL NUCLEUS DNA; DNA GLYCOSYLTRANSFERASE; FREE RADICAL; PROTEIN OGG1; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER; CONTROLLED STUDY; ENZYME LOCALIZATION; GENETIC ASSOCIATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SENESCENCE; SPONTANEOUS MUTATION;

AGING; AMINO ACID SUBSTITUTION; ANIMALS; DNA; DNA MUTATIONAL ANALYSIS; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; GENOME; GUANINE; LIFE EXPECTANCY; LIVER; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; MUTATION; N-GLYCOSYL HYDROLASES; NUCLEAR LOCALIZATION SIGNALS; PHENOTYPE; SURVIVAL ANALYSIS;

MAMMALIA;

EID: 0035873872     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00511-1     Document Type: Article

References (43)

1. Grollman A.P., Moriya M. Mutagenesis by 8-oxoguanine an enemy within . Trends Genet. 9:1993;246-249.
2. Wood M.L., Dizdaroglu M., Gajewski E., Essigmann J.M. Mechanistic studies of ionizing radiation and oxidative mutagenesis genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome . Biochemistry. 29:1990;7024-7032.
3. Moriya M., Ou C., Bodepudi V., Johnson F., Takeshita M., Grollman A.P. Site-specific mutagenesis using a gapped duplex vector a study of translation synthesis past 8-oxodeoxyguanosine in E. coli . Mutat. Res. 254:1991;281-288.
4. Shibutani S., Takeshita M., Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature. 349:1991;431-434.
5. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions. J. Biol. Chem. 267:1992;166-172.
6. Chung M.H., Kim H.S., Ohtsuka E., Nishimura S. An endonuclease activity in human polymorphonuclear neutrophils that removes 8-hydroxyguanine residues from DNA. Biochem. Biophys. Res. Commun. 178:1991;1472-1478.
7. Yamamoto F., Kasai H., Bessho T., Chung M.H., Inoue H., Ohtsuka E., Hori T., Nishimura S. Ubiquitous presence in mammalian cells of enzymatic activity specifically cleaving 8-hydroxyguanine-containing DNA. Jpn. J. Cancer Res. 83:1992;351-357.
8. Bessho T., Tano K., Kasai H., Ohtsuka E., Nishimura S. Evidence for two DNA repair enzymes for 8-hydroxyguanine (7, 8-dihydro-8-oxoguanine) in human cells. J. Biol. Chem. 268:1993;19416-19421.
9. Nagashima M., Sasaki A., Morishita K., Takenoshita S., Nagamachi Y., Kasai H., Yokota J. Presence of human cellular protein(s) that specifically binds and cleaves 8-hydroxyguanine containing DNA. Mutat. Res. 383:1997;49-59.
10. Le Page F., Kwoh E.E., Avrutskaya A., Gentil A., Leadon S.A., Sarasin A., Cooper P.K. Transcription-coupled repair of 8-oxoguanine requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome . Cell. 101:2000;159-171.
11. Le Page F., Klungland A., Barnes D.B., Sarasin A., Boiteux S. Transcription coupled repair of 8-oxoguanine in murine cells the Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences . Proc. Natl. Acad. Sci. USA. 97:2000;8397-8402.
12. Arai K., Morishita K., Shinmura K., Kohno T., Kim S., Nohmi T., Taniwaki M., Ohwada S., Yokota J. Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage. Oncogene. 14:1997;2857-2861.
13. Rosenquist T.A., Zharkov D.O., Grollman A.P. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc. Natl. Acad. Sci. USA. 94:1997;7429-7434.
14. Aburatani H., Hippo Y., Ishida T., Takashima R., Matsuda C., Kodama T., Takao M., Yasui A., Yamamoto K., Asano M., Fukasawa K., Yoshinari T., Inoue H., Ohtsuka E., Nishimura S. Cloning and characterization of mammalian 8-hydrxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res. 57:1997;2151-2156.
15. Lu R., Nash H.M., Verdine G.L. A mammalian DNA repair enzyme that excises oxidatively damaged guanines map to a locus frequently lost in ling cancer. Curr. Biol. 7:1997;397-407.
16. Chevillard S., Radicella J.P., Levalois C., Lebeau J., Poupon M.-F., Oudard S., Dutrillaux B., Boiteux S. Mutationsin OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumors. Oncogene. 16:1998;3083-3086.
17. Shinmura K., Kohno T., Kasai H., Koda K., Sugimura H., Yokota J. Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer. Jpn. J. Cancer Res. 89:1998;825-828.
18. Ishida T., Takashima R., Fukayama M., Hamada C., Hippo Y., Fujii T., Moriyama S., Matsuba C., Nakahori Y., Morita H., Yazaki Y., Kodama T., Nishimura S., Aburatani H. New DNA polymorphisms of human MMH/OGG1 gene prevalance of one polymorphism among lung-adenocarcinom patients in Japanese . Int. J. Cancer. 80:1999;18-21.
19. Boiteux S., Radicella J.P. The human OGG1 gene structure, functions, and its implication in the process of carcinogenesis . Arch. Biochem. Biophys. 377:2000;1-8.
20. Dianov G., Bischoff C., Sunesen M., Bohr V.A. Repair of 8-oxoguanine in DNA is deficient in Cockayne syndrome group B cells. Nucleic Acids Res. 27:1999;1365-1368.
21. Klungland A., Rosewell I., Hollenbach S., Larsen E., Daly G., Epe B., Seeberg E., Lindahl T., Barnes D.E. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc. Natl. Acad. Sci. USA. 96:2000;13300-13305.
22. Minowa O., Arai T., Hirano M., Monden Y., Nakai S., Fukuda M., Itoh M., Takano H., Hippou Y., Aburatani H., Masuura K., Nohmi T., Nishimura S., Noda T. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc. Natl. Acad. Sci. USA. 97:2000;4156-4161.
23. Choi J.Y., Kim H.S., Kang H.K., Lee D.W., Choi E.M., Chung M.-H. Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radic. Biol. Med. 27:1999;848-854.
24. Takeda T., Hosokawa M., Higuchi K. Senescence-accelerated mouse (SAM) a novel murine model of senescence . Exp. Gerontol. 32:1997;105-109.
25. Liu J., Mori A. Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity, and reduced glutathione level in brain and liver in SAM a comparison with ddY mice . Mech. Aging Dev. 71:1993;23-30.
26. Choi J.H., Kim J.I., Kim D.W., Moon Y.S., Kim I.S., Chung H.Y. Age-related physiological changes in brain membranes of senescence accelerated mouse (SAM). Takeda T. The SAM model of senescence. 1994;321-324.
27. Edamatsu R., Mori A., Packer L. The spin-trap N-tert-alpha-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse. Biochem. Biophys. Res. Commun. 211:1995;847-849.
28. Park J.W., Choi C.H., Kim M.K., Chung M.H. Oxidative status in senescence-accelerated mice. J. Gerontol. 51:1996;337-345.
29. Butterfield A., Howard B.J., Yatin S., Allen K.L., Carney J.M. Free radical oxidation of brain proteins in accelerated senescence and its modulation by N-tert-butyl-alpha-phenylnitrone. Proc. Natl. Acad. Sci. USA. 94:1997;674-678.
30. Odagiri Y., Uchida H., Hosokawa M., Takemoto K., Morley A.A., Takeda T. Accelerated accumulation of somatic mutations in the senescence-accelerated mouse. Nature Genet. 19:1998;116-117.
31. Hattori-Nakakuki Y., Nishigori C., Okamoto K., Imamura S., Hiai H., Toyokuni S. Formation of 8-hydry-2′-deoxyguanosine in epidermis of hairless mice exposed to near UV. Biochem. Biophys. Res. Commun. 201:1994;1132-1139.
32. Naiki H., Higuchi K., Shimada A., Takeda T., Nakakuki K. Genetic analysis of murine senile amyloidosis. Lab. Invest. 68:1993;332-337.
33. Hosokawa M., Kasai R., Higuchi K., Takeshita S., Shimizu K., Hamamoto H., Honma A., Irino M., Toda K., Matsumura A., Takeda T. Grading score system a method for evaluation of the degree of senescence in senescence accelerated mouse (SAM) . Mech. Aging Dev. 26:1984;91-102.
34. Lilly F., Pincus T. Genetic control of murine viral leukemogenesis. Adv. Cancer Res. 17:1973;231-277.
35. Festing M.F.W., Blackmore D.K. Life span of specified-pathogen-free (MRC category 4) mice and rats. Lab. Anim. 5:1971;179-192.
36. Murphy E.D. Lymphoproliferation (lpr) and other single-locus models for murine lupus. Gershwin M.E., Merchant B. Immunologic defects in laboratory animals. vol. I:1981;143-173 Plenum Press, New York.
37. Simpson L.O. An NZB virus or NZB mice with viral infections? Lab. Anim. 10:1976;249-260.
38. Murphy E.D. SJL/J, a new inbred strain of mouse with a high early incidence of reticulum cell neoplasm. Proc. Am. Assoc. Cancer Res. 4:1963;46.
39. Onda M., Hanada K., Kawachi H., Ikeda H. Escherichia coli mutM suppresses illegitimate recombination induced by oxidative stress. Genetics. 151:1999;439-446.
40. Yamagishi H., Kunisada T., Takeda T. Amplification of extrachromosomal small circular DNAs in a murine model of accelerated senescence. Mech. Aging Dev. 29:1985;101-103.
41. Nisitani S., Hosokawa M., Sasaki M.S., Yasuoka K., Naiki H., Matsushita T., Takeda T. Acceleration of chromosome aberrations in senescence-accelerated strains of mice. Mutat. Res. 237:1990;221-228.
42. Tobita M., Nakamura S., Nagano I., Itoh A., Itoyama Y. DNA single-strand breaks in hippocampal regions of senescence-accelerated mice (SAMP8/Ta) detected by modified in situ nick translation procedure. Takeda T. The SAM model of senescence. 1994;125-128 Excerpta Medica, Amsterdam.
43. He P., Yasumoto K. Dietary butylated hydroxytoluene counteracts with paraquat to reduce the rate of hepatic DNA single strand breaks in senescence-accelerated mice. Mech. Aging Dev. 76:1994;43-48.